A5000129537- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Aquaculture Nutrition and Growth
- Insect Utilization and Effects
- Aquatic life and conservation
- Chemotherapy-induced cardiotoxicity and mitigation
- Chemotherapy-induced organ toxicity mitigation
- thermodynamics and calorimetric analyses
- Paraoxonase enzyme and polymorphisms
- Aquaculture disease management and microbiota
- Lung Cancer Treatments and Mutations
- Tryptophan and brain disorders
- Bone and Dental Protein Studies
- Epigenetics and DNA Methylation
- Chronic Disease Management Strategies
- Collagen: Extraction and Characterization
- Metabolomics and Mass Spectrometry Studies
- Silymarin and Mushroom Poisoning
- Healthcare and Environmental Waste Management
- Uterine Myomas and Treatments
- Bone health and osteoporosis research
- Reproductive biology and impacts on aquatic species
- Bee Products Chemical Analysis
- Animal and Plant Science Education
- Advanced Biosensing Techniques and Applications
Marche Polytechnic University
2020-2025
Ospedali Riuniti di Ancona
2020
Politecnico di Milano
2018
The widespread use of plastics determines the inevitable human exposure to its by-products, including microplastics (MPs), which enter organism mainly by ingestion, inhalation, and dermal contact. Once internalised, MPs may pass across cell membranes translocate different body sites, triggering specific cellular mechanisms. Hence, potential health impairment caused internalisation accumulation is prime concern, as confirmed numerous studies reporting evident toxic effects in various animal...
The attempt to replace marine-derived ingredients for aquafeed formulation with plant-derived ones has met some limitations due their negative side effects on many fish species. In this context, finding new, sustainable able promote welfare is currently under exploration. the present study, poultry by-products and Hermetia illucens meal were used vegetable protein fraction in diets totally deprived of intended gilthead seabream (Sparus aurata). After a 12-week feeding trial,...
In the present study, an organic substrate (coffee silverskin) enriched with spirulina (Arthrospira platensis; 15% w/w), as a source of lipids and bioactive molecules, was used to rear black soldier fly (Hermetia illucens) prepupae. Three grossly isonitrogenous, isoproteic, isolipidic isoenergetic experimental diets for rainbow trout (Oncorhynchus mykiss) juveniles were then produced: control diet (HM0) mostly including fish meal oil, two other test named HM3 HM20, in which 3 or 20% marine...
Oral squamous cell carcinoma represents the most aggressive and frequent form of head neck cancer. Due to drug resistance, 5-year survival rate patients with advanced disease is less than 50%. In order identify molecular targets for effective oral cancer treatment, we focused on paraoxonase-2 enzyme. Indeed, based data previously obtained from preliminary immunohistochemistry Western blot analyses performed tissue specimens, enzyme was found be upregulated in tumor compared normal mucosa....
Abstract Background One of the main factors for osseointegration dental implants is development an adequate soft tissue barrier, mainly composed by collagen, which protects implant from bacterial development. The structural features peri-implant collagen are influenced components and, in particular, type surface. In clinical practice, healing abutments characterized smooth surfaces, named machined. Recently, a new laser technique, Synthegra, has been developed to obtain topography-controlled...
Abstract Background Individuals with type 2 diabetes (T2D) face an increased mortality risk, not fully captured by canonical risk factors. Biological age estimation through DNA methylation (DNAm), i.e . the epigenetic clocks, is emerging as a possible tool to improve stratification for multiple outcomes. However, whether these tools predict independently of factors in subjects T2D unknown. Methods Among cohort 568 patients followed 16.8 years, we selected subgroup 50 subjects, 27 survived...
In the present study, cytotoxic effects of 5-azacytidine on primary Oral Squamous Cell Carcinoma cells (OSCCs) from human biopsies, and Cancer Stem Cells (CSCs) same samples, were investigated by an in vitro Fourier Transform InfraRed Microscospectroscopy (FTIRM) approach coupled with multivariate analysis. OSCC is aggressive tumoral lesion epithelium, accounting for ~90% all oral cancers. It usually diagnosed advanced stages, this causes a poor prognosis low success rates surgical, as well...
Oral Squamous Cells Carcinoma (OSCC) is characterised by the risk of recurrence and onset a refractoriness response to chemotherapy drugs.
Currently, various analytical techniques, including scanning electron microscopy, X-Ray diffraction, microcomputed tomography, and energy dispersive X-ray spectroscopy, are available to study the structural or elemental features of hard dental tissues. In contrast these approaches, Raman Microspectroscopy (RMS) has great advantage simultaneously providing, at same time on sample, a morpho-chemical correlation between microscopic information from visual analysis sample its chemical...
OPINION article Front. Oncol., 09 January 2024Sec. Thoracic Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1308460
High resolution analysis of collagen bundles could provide information on tumor onset and evolution. This study was focused the microarchitecture biomolecular organization in oral tongue squamous cell carcinoma (OTSCC). Thirty-five OTSCC biopsy samples were analyzed by synchrotron-based phase-contrast microcomputed tomography Fourier transform infrared imaging (FTIRI) spectroscopy. PhC-microCT evidenced presence reduced disorganized area compared to extratumoral (ExtraT) one. FTIRI also...
During their life, women are likely to develop uterine diseases, which often compromise fertile and perimenopausal age. Besides benign lesions like leiomyomas, several malignant neoplasms can occur, such as the leiomyosarcoma, represents most frequent malignancy among rarest cancers. It presents variants similar both neoplasms, sometimes it shares symptoms with counterpart. In this scenario, for a correct diagnosis successful prognosis, is mandatory detect new reliable markers strengthen...
Multicellular spheroids are the new frontier for studying how tumour micro-environment interferes with drug uptake and response, since they can reproduce a three-dimensional cellular organisation mimicking behaviour of in vivo solid tissues.In this study, we exploited Focal Plane Array -Fourier Transform Infrared Imaging spectroscopy to characterize biochemical features, terms distribution composition meaningful macromolecules (lipids, proteins, sugars nucleic acids), malignant pleural...
Carpione (Salmo carpio, Linnaeus 1758) is an endangered precious endemism of Lake Garda (Northern Italy), the largest Italian lake. To date, several bottlenecks about its culture remain unsolved, including identification a proper growth-out diet. The aim present study was to test four different grossly isolipidic, isoproteic, and isoenergetic diets in which main ingredients had origin. Specifically, diet currently used by local farmers for carpione culture, largely based on marine...
The corpus callosum (CC) is the largest interhemispheric commissure of mammalian brain, and it includes axons, cortical neurons, glial cells. It mainly composed myelin, a lipidic sheath which produced by cell membranes; myelin wrapped up around axons plays fundamental role in fast conduction neuronal electrical signals. human CC divided into various anatomical regions, with different axonal composition, including, from front to back, genu, body or trunk, isthmus, splenium. Corpus undergoes...
Raman MicroSpectroscopy (RMS) is a powerful label-free tool to probe the effects of drugs at cellular/subcellular level.
The agricultural sector is required to produce food at the same pace as population growth, while accounting for pollution and costs. For this reason, conservative practices have been employed worldwide. Attenuated Total Reflectance–Fourier Transform Infrared (ATR-FTIR) spectroscopy has ability provide a snapshot of macromolecular composition sample in timely cost-effective way it widely applied field agriculture assess quality. aim study was exploit ATR-FTIR impact different soil tillage...
Integrated Mach-Zehnder interferometers, ring resonators, Bragg reflectors or simple waveguides are commonly used as photonic biosensing elements. They can be for label-free detection relating the changes in optical signal realtime, power spectral response, to presence and even quantity of a target analyte on surface waveguide. The method has advantages term sample preparation but it is more sensitive spurious effects such temperature refractive index variation, biological noise, etc. Label...