A5018202936- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Advanced X-ray Imaging Techniques
- Nuclear Physics and Applications
- Advanced ceramic materials synthesis
- Aluminum Alloys Composites Properties
- Dental Radiography and Imaging
- 3D Printing in Biomedical Research
- X-ray Diffraction in Crystallography
- Orthopaedic implants and arthroplasty
- Metal and Thin Film Mechanics
- Additive Manufacturing and 3D Printing Technologies
- Periodontal Regeneration and Treatments
- Spaceflight effects on biology
- Tissue Engineering and Regenerative Medicine
- Bone health and osteoporosis research
- Endodontics and Root Canal Treatments
- Anatomy and Medical Technology
- Electrospun Nanofibers in Biomedical Applications
- Advanced X-ray and CT Imaging
- Microstructure and Mechanical Properties of Steels
- Diverse Musicological Studies
- Graphene and Nanomaterials Applications
- dental development and anomalies
Marche Polytechnic University
2015-2024
University of Siena
2022
The Abdus Salam International Centre for Theoretical Physics (ICTP)
2015
University of Chieti-Pescara
2015
In-Q-Tel
2015
Istituto Nazionale Biostrutture e Biosistemi
2009-2013
National Interuniversity Consortium for the Physical Sciences of Matter
2009-2013
Istituto Nazionale per la Fisica della Materia
2000-2005
Ospedali Riuniti di Ancona
2000-2004
Abstract Mesenchymal stem cells deriving from dental pulp differentiate into osteoblasts capable of producing bone. In previous studies, we extensively demonstrated that, when seeded on collagen I scaffolds, these can be conveniently used for the repair human mandible defects. Here, assess stability and quality regenerated bone vessel network 3 years after grafting intervention, with conventional procedures in-line holotomography, an advanced phase-imaging method using synchrotron radiation...
Chronological age per se cannot be considered a prognostic risk factor for outcomes after elective surgery, whereas frailty could be. A simple and easy-to-get marker frailty, such as handgrip strength (HGS), may support the surgeon in decision an adequate healthcare plan.
Bone is a complex dynamic tissue undergoing continuous remodeling process. Gravity physical force playing role in the and contributing to maintenance of bone integrity. This article reports an investigation on alterations microarchitecture that occurred wild type (Wt) pleiotrophin-transgenic (PTN-Tg) mice exposed near-zero gravity International Space Station (ISS) during Mice Drawer System (MDS) mission, date, longest permanence (91 days) space. The transgenic mouse strain over-expressing...
Human dental pulp stem cells (hDPSCs) are mesenchymal that have been successfully used in human bone tissue engineering. To establish whether these can lead to a ready be grafted, we checked DPSCs for their osteogenic and angiogenic differentiation capabilities with the specific aim of obtaining new tool transplantation. Therefore, hDPSCs were specifically selected from stromal-vascular fraction, using appropriate markers, cultured. Growth curves, expression bone-related calcification...
Abstract Lipocalin‐2 (LCN2) is a protein largely expressed in many tissues, associated with different biological phenomena such as cellular differentiation, inflammation and cancer acting survival/apoptotic signal. We found that LCN2 was during osteoblast differentiation we generated transgenic (Tg) mice over‐expressing bone. Tg were smaller presented bone microarchitectural changes both endochondral intramembranous bones. In particular, bones displayed thinner layer of cortical decreased...
Background and Objective In the present study, early stages of in vitro bone formation collagenated porcine scaffolds cultured with human periodontal ligament cells were investigated. The comparison between osteogenic potential this structure basal differentiating culture media was explored to predict mechanism its biological behavior as graft defect. Results validated by synchrotron radiation X‐Ray phase contrast computed microtomography (micro‐ CT ). As disease plays a key role systemic...
Introduction: Dental implant placement can be challenging when insufficient bone volume is present and augmentation procedures are indicated. The purpose was to assess clinically histologically a specimen of 30%HA-60%β-TCP BCP 3D-printed scaffold, after 7-years. Case Description: patient underwent regeneration maxillary buccal plate with biphasic-HA block in 2013. After 7-years, the regenerated harvested processed perform microCT histomorphometrical analyses. Results: microarchitecture study...
Background: In dental implants, micro-gaps at the fixation–abutment interface can cause peri-implantitis and/or loosening or loss of fixation screw; therefore, three-dimensional imaging is widely used to examine different types connections. present study, we focus on analysis biconometric connections detect and (possibly) measure presence in as-positioned state after repeated loading unloading. Methods: Seven implants were characterized using micro-computed tomography (micro-CT). two...
In recent years, there has been interest on the fabrication of systems using particulates or block-based approach for bone tissue engineering (TE) scaffolds, possessing porous interconnected structures. fact, these particular morphologies greatly increase surface area more chemical and biological reactions to take place.This study was designed demonstrate unique capability synchrotron radiation x-ray microtomography (micro-CT) in offering an advanced characterization coralline-derived...
Spatiotemporal interactions play important roles in tissue development and function, especially stem cell-seeded bioscaffolds. Cells interact with the surface of bioscaffold polymers influence material-driven control cell differentiation. In vitro cultures different human progenitor cells, that is, endothelial colony-forming cells (ECFCs) from a healthy patient Kaposi sarcoma (an angioproliferative disease) CD133+ muscle-derived (MSH 133+ cells), were seeded onto polyglycolic acid-polylactic...
Successful bone regeneration using both granules and blocks of biphasic calcium phosphate materials has been reported in the recent literature, some clinical applications for maxillary sinus elevation, but long-term kinetics still not fully investigated.Twenty-four bilateral augmentation procedures were performed grafted with hydroxyapatite/β-tricalcium 30/70, 12 blocks. The samples retrieved at different time points evaluated regeneration, graft resorption, neovascularization, morphometric...
This study aimed to compare two different bulk-filling techniques, evaluating the internal and external adaptation of class II resin-composite restorations, by analysing gap formation using microcomputed tomography (µ-CT) scanning electronic microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDS). Two standardized mesio/disto-occlusal (MO/DO) cavities were prepared in eight extracted human third molars that divided, according filling technique used, following groups (n = 4):...
Alveolar bone defects are usually the main concern when planning implant treatments for appropriate oral rehabilitation of patients. To improve local conditions and achieve treatments, there several methods used increasing volume, among which one most successful, versatile, effective is considered to be guided regeneration. The aim this demonstrative study was propose an innovative analysis protocol evaluation effect photobiomodulation on regeneration process, using rat calvarial 5 mm in...
This work aimed to compare the capability of Streptococcus oralis adhere a novel surface, double-etched titanium (DAE), in respect machined and single-etched titanium. The secondary outcome was establish which topographical features could affect interaction between implant surface bacteria. samples’ superficial were characterized using scanning electron microscopy (SEM) energy dispersive x-ray spectrometry (EDS), wetting properties tested through sessile methods. also analyzed with atomic...
One of the most important aspects bone remodeling is constant turnover mainly driven by mechanical loading stimulus. The process produces changes not only in microarchitecture but also density distribution mineralized matrix - i.e. calcium concentrations- and osteocyte lacunar network. Synchrotron radiation-based X-ray microtomography (microCT) has proven to be an efficient technique, capable achieve analysis 3D architecture local mineralization at different hierarchical length scales,...
The aim of the present human observational study is to provide morphologic and morphometric analysis peri-implant connective tissue next abutments with divergent or convergent macro-geometry different surface micro-characteristics.Thirty patients were rehabilitated single implants in posterior area one out three healing a one-stage technique: machined abutment (DIV-MAC), (CONV-MAC) ultrathin threaded (CONV-UTM). At 3 months postimplant insertion, soft was harvested; following outcomes...
The macroscopic structure of bone has been traditionally studied through x-ray radiography or tomography. However, the resolution limits these techniques do not enable reconstruction composite architecture at nanometer level. Compared with histomorphometry, micro-CT shown its efficiency in providing nondestructive and rapid 3D images measurements on microstructure. Micro-CT higher achieved synchrotron radiation-based computed microtomography (SRμCT).The aim this study was a histological...
The recent introduction of stem cells in cardiology provides new tools understanding the regenerative processes normal and pathological heart has opened a search for therapeutic strategies. Recent published reports have contributed to identifying possible cellular therapy approaches generate myocardium, involving transcoronary intramyocardial injection progenitor cells. However, one limiting factors overall interpretation clinical results obtained by cell is represented lack...