A5074482238- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Reproductive tract infections research
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- COVID-19 and healthcare impacts
- Reproductive System and Pregnancy
- Global Cancer Incidence and Screening
- Urological Disorders and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Risks and Factors
- Pelvic and Acetabular Injuries
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Ectopic Pregnancy Diagnosis and Management
- Urologic and reproductive health conditions
- Head and Neck Cancer Studies
- Bone health and osteoporosis research
Marche Polytechnic University
2016-2025
Università Cattolica del Sacro Cuore
2025
MemorialCare Health System
2021
Centro di Riferimento Oncologico
2019
Woman's Hospital
2017
Presidio Ospedaliero
2015
Inefficient targeting of muscle stem cells (MuSCs), also called satellite cells, represents a major bottleneck current therapeutic strategies for muscular dystrophies, as it precludes the possibility promoting compensatory regeneration. Here we describe muscle-targeting delivery platform, based on gold nanoparticles, that enables release oligonucleotides into MuSCs. We demonstrate AuNPs conjugation to an aptamer against α7/β1 integrin dimers directs either local or systemic microRNA-206...
Objective: Estimating the impact of sonographically identified multiple or large (≥5 cm in diameter) fibroids on obstetric outcomes.Methods: Retrospective cohort study 219 women with uterine (identified a routine second-trimester ultrasound survey over 3-year period, 2010–2012) and their age-matched controls. Inclusion criteria were singleton pregnancy, delivery at >24 weeks gestation no pathological conditions (chronic hypertension, gestational diabetes pre-existing mellitus, anomalies...
The present review regarding atypical endometrial hyperplasia (AEH) focused on the main debated factors this challenging clinical condition: (i) predictive variables of occult cancer (EC); (ii) rate EC underestimation according to different sampling methods; and (iii) appropriateness lymph node status assessment. When is detected, approximately 90% cases include low-risk EC, although intermediate/high-risk have been found in 10-13% women with cancer. Older age, diabetes, high BMI, increased...
Although the etiology of leiomyoma is unclear, a progenitor/undifferentiated cell population has been described whose dysregulation may be involved in onset uterine conditions. Moreover, inflammation development several tumors. The aim this work was to understand if progenitor cells sustain chronic inflammatory microenvironment that enhances development. Cells from 12 human and normal myometrium samples same patients were vitro isolated exhaustively characterized (morphology, proliferation,...
The aim of this study was to evaluate the effect vitamin D supplementation in women with hypovitaminosis and "small burden" uterine fibroids.This focused on 208 diagnosed fibroids concomitant D, from January December 2014. One hundred eight initial population were fibroids. Among them, those who underwent a proper constituted "study group" (n = 53), while spontaneously refused therapy or did not perform it properly, "control 55). characteristics fibroids, fibroid-related symptoms, serum...
Aim: The aim of this study was to assess the vitamin D serum level in women with ovarian endometriosis; specifically, a possible correlation between dimensions endometriomas and levels evaluated.Materials methods: This an observational childbearing-age diagnosed singleton endometrioma from January 2015 December 2015. Women multiple or extraovarian endometriosis were excluded.Results: Forty-nine constituted initial cohort. In these women, mean (±SD) 25-OH-D3 22.0 (±8.9) ng/ml, 42 them (85.7%)...
The COVID-19 pandemic caused by SARS-CoV-2 has radically changed global healthcare. On May 13, 2020, all countries of the European Region reported their status, with 1 757 814 confirmed cases and 157 923 deaths.[1][1] Each country initiated measures to reduce impact
The objective of this study was to analyze the impact cone characteristics (depth, transverse diameter, and volume) on subsequent pregnancies after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN 2-3). Pregnancy outcomes (preterm birth, gestational age at mode delivery, birth weight) 501 women with singleton gestations no previous preterm or history late miscarriage, who had previously undergone a single LEEP CIN 2-3, were retrospectively analyzed...
Up to 40% of women with atypical endometrial hyperplasia (AEH) can reveal cancer (EC) at hysterectomy. The pre-operative sampling method (ESM) and some independent predictors may affect this outcome. present study aimed compare the rate EC hysterectomy in AEH undergoing dilation curettage (D&C), hysteroscopically-guided biopsy (HSC-bio), or hysteroscopic resection (HSC-res). secondary outcome was reliability ESMs showing variables associated EC.Two-hundred-and-eight consecutive between...
Objective The real-world PatiEnt satisfactiON studY (PEONY) involves postmenopausal women already treated or starting local estrogen therapy (LET) ospemifene. aim of the present analysis was to assess treatment satisfaction and persistence, effectiveness patient-reported outcomes (PROs) in sexual function quality life after 6 months with LET ospemifene treat vulvovaginal atrophy (VVA).
To analyze the clinical management, outcomes, and trend in hysterectomy rates (HR) patients who underwent this procedure for cervical intraepithelial neoplasia (CIN).Multicentric retrospective observational study conducted on 242 CIN between 2010 2020 nine Italian institutions. Hysterectomy invasive or micro-invasive neoplasia, sub-total hysterectomy, trachelectomy were excluded.A significant increase of HR was recorded (P = 0.002, r 0.81; C.I. 95%: 0.415-0.949); increased from 0.46% year to...