A5025722381- Essential Oils and Antimicrobial Activity
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Antimicrobial agents and applications
- Wound Healing and Treatments
- Biopolymer Synthesis and Applications
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Protein Hydrolysis and Bioactive Peptides
- Diabetic Foot Ulcer Assessment and Management
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Natural Fiber Reinforced Composites
- Polymer Surface Interaction Studies
- Surgical Sutures and Adhesives
- Microplastics and Plastic Pollution
- Advanced Cellulose Research Studies
- Graphene and Nanomaterials Applications
- Infection Control and Ventilation
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Cell Adhesion Molecules Research
University of Minho
2020-2024
Sorbonne Université
2020-2021
Université Sorbonne Paris Nord
2020-2021
Laboratoire de Recherche Vasculaire Translationnelle
2019-2021
Inserm
2017-2021
CeNTI (Portugal)
2020-2021
Universidade do Porto
2011-2016
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2016
Institute for Biotechnology and Bioengineering
2010
Universitat Politècnica de València
2010
The increased resistance of bacteria against conventional pharmaceutical solutions, the antibiotics, has raised serious health concerns. This stimulated interest in development bio-based therapeutics with limited resistance, namely, essential oils (EOs) or antimicrobial peptides (AMPs). study envisaged evaluation efficacy selected biomolecules, namely LL37, pexiganan, tea tree oil (TTO), cinnamon leaf (CLO) and niaouli (NO), four commonly associated to nosocomial infections: Staphylococcus...
Chitosan (Ch) is a nontoxic and biocompatible polysaccharide extensively used in biomedical applications. Ch, as polycation, can be combined with anionic polymers by layer-by-layer (LbL) self-assembly, giving rise to multilayered complexed architectures. These structures tissue engineering strategies, drug delivery systems, or artificial matrices mimicking the extracellular microenvironment. In this work, Ch was poly(γ-glutamic acid) (γ-PGA). γ-PGA polyanion, which microbially produced,...
Chronic wounds (CW) create numerous entryways for pathogen invasion and prosperity, further damaging host tissue hindering its remodeling repair. Essential oils (EOs) exert quick efficient antimicrobial (AM) action, unlikely to induce bacterial resistance. Cinnamon leaf clove (CLO CO) display strong AM activity, namely against Staphylococcus aureus Pseudomonas aeruginosa. Chitosan (CS) is a natural biodegradable cationic polysaccharide, also widely known features. CS poly (vinyl alcohol)...
The destruction of cells using the mechanical activation magnetic nanoparticles with low-frequency fields constitutes a recent and interesting approach in cancer therapy. Here, we showed that superparamagnetic iron oxide as small 6 nm were able to induce death pancreatic cancer-associated fibroblasts, chosen model. An exhaustive screening amplitude, frequency, type (alternating
It is increasingly urgent to develop new therapeutic systems combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder patient's recovery. In this sense, a targeted controlled delivery biomolecules allows overcoming limitations conventional systems, taking user one step closer successful treatment disease. Hydrogels have been highlighted for their drug abilities, particularly tunable properties, like...
New approaches to deal with the growing concern associated antibiotic-resistant bacteria are emerging daily. Essential oils (EOs) natural antimicrobial substances great potential mitigate this situation. However, their volatile nature, in liquid-free form, has restricted generalized application biomedicine. Here, we propose use of cellulose acetate (CA)/polycaprolactone (PCL) wet-spun fibers as delivery platforms selected EOs fight infections caused by Staphylococcus aureus (S. aureus) and...
One of the most important measures implemented to reduce SARS-CoV-2 transmission has been use face masks. Yet, mask options available in market display a passive action against virus, not actively compromising its viability. Here, we propose overcome this limitation by incorporating antiviral essential oils (EOs) within polycaprolactone (PCL) electrospun fibrous mats be used as intermediate layers individual protection Twenty EOs selected based on their antimicrobial nature were examined for...
In this research, we propose to engineer a nanostructured mat that can simultaneously kill bacteria and promote an environment conducive healing for prospective wound care. Polyvinyl alcohol (PVA) cellulose acetate (CA) were combined at different polymer ratios (100/0, 90/10, 80/20% v/v), electrospun crosslinked with glutaraldehyde vapor. Crosslinked fibers increased in diameter (from 194 278 nm), retaining their uniform structure. Fourier-transform infrared spectroscopy thermal analyses...
Poly(L-lactic acid), PLLA, a synthetic biodegradable polyester, is widely accepted in tissue engineering. Hyaluronic acid (HA), natural polymer, exhibits an excellent biocompatibility, influences cell signaling, proliferation, and differentiation. In this study, HA crosslinking was performed by immersion of the polysaccharide water-acetone mixtures containing glutaraldehyde (GA). The objective work to produce PLLA scaffolds with pores coated HA, that could be beneficial for bone engineering...
Human mesenchymal stem cells (hMSCs) have an enormous potential for tissue engineering and cell-based therapies.With a of differentiation into multiple lineages immune-suppression, these play key role in remodelling regeneration.Here method hMSC recruitment is described, based on the incorporation chemokine Chitosan (Ch)/ Poly(γ-glutamic acid) (γ-PGA) complexes.Ch nontoxic, cationic polysaccharide widely investigated.γ-PGA hydrophilic, non-toxic, biodegradable negatively charged poly-amino...
Nisin Z, an amphipathic peptide, with a significant antibacterial activity against Gram-positive bacteria and low toxicity in humans, has been studied for food preservation applications. Thus far, very little research done to explore its potential biomedicine. Here, we report the modification of sodium alginate (SA) gelatin (GN) blended microfibers, produced via wet-spinning technique, purpose eradicating Staphylococcus aureus-induced infections. Wet-spun SAGN microfibers were successfully...
Infection is a major issue in chronic wound care. Different dressings have been developed to prevent microbial propagation, but an effective, all-in-one (cytocompatible, antimicrobial and promoter of healing) solution still be uncovered. In this research, polyvinyl alcohol (PVA) nanofibrous mats reinforced with cellulose nanocrystal (CNC), at 10 20% v/v ratios, were produced by electrospinning, crosslinked glutaraldehyde vapor doped specialized peptides. Crosslinking increased the mats'...
The development of advanced facemasks stands out as a paramount priority in enhancing healthcare preparedness. In this work, different polypropylene non-woven fabrics (NWF) were characterised regarding their structural, physicochemical and comfort-related properties. selected NWF for the intermediate layer was functionalised with zinc oxide nanoparticles (ZnO NPs) 0.3 1.2wt% using three methods: electrospinning, dip-pad-dry exhaustion. After confirmation ZnO NP content distribution within...