A5082038549- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Nanoparticle-Based Drug Delivery
- Collagen: Extraction and Characterization
- Tissue Engineering and Regenerative Medicine
- Bone and Dental Protein Studies
- Orthopaedic implants and arthroplasty
- Calcium Carbonate Crystallization and Inhibition
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Dental materials and restorations
- Nerve injury and regeneration
- Spaceflight effects on biology
- Osteoarthritis Treatment and Mechanisms
- Titanium Alloys Microstructure and Properties
- Advanced biosensing and bioanalysis techniques
- Bone Metabolism and Diseases
- Metal complexes synthesis and properties
- Additive Manufacturing and 3D Printing Technologies
- Supramolecular Self-Assembly in Materials
- Laser-Ablation Synthesis of Nanoparticles
- Cellular Mechanics and Interactions
Institute of Science and Technology for Ceramics
2015-2024
National Research Council
2015-2024
Ospedale per gli Infermi
2015-2021
Istituto Ortopedico Rizzoli
2010-2018
University of Milan
2006-2015
National Academies of Sciences, Engineering, and Medicine
2012-2014
Consorzio Roma Ricerche
2013
Orthopedic Institute
2011-2012
University of Bologna
2010-2012
University of Milano-Bicocca
2007-2010
Abstract Background Although many nerve prostheses have been proposed in recent years, the case of consistent loss nervous tissue peripheral injury is still a traumatic pathology that may impair patient's movements by interrupting his motor-sensory pathways. In last few decades engineering has opened door to new approaches;: however most them make use rigid channel guides cause cell due lack physiological local stresses exerted over during movement. Electrospinning technique makes it...
A consistent series of Pt (II) polypyridyl complexes (i.e., LDP‐10–25 ), previously obtained and characterized by our research group, underwent extensive biological investigations to verify their activity profile as target‐based anticancer agents. Preliminary in vitro screening at 10 μM against three tumor cell lines known overexpress DNA G‐4 (MDA‐MB 231, U87, U2‐OS) pointed out that four them, namely, LDP‐15 , LDP‐16 LDP‐24 LDP‐25 had promising cytotoxic compared with cisplatin. Therefore,...
The destruction and hollowing of entire tissue segments represent an insurmountable barrier to axonal regeneration therapeutics in chronic spinal cord injury. To circumvent this problem, we engineered neural prosthetics, by assembling electrospun nanofibers self-assembling peptides into composite guidance channels transplanted them the cysts a postcontusive, injury rat model, also providing delivery proregenerative cytokines. Six months later conspicuous reconstruction was observed. cyst...
Superparamagnetic nanoparticles (MNPs) have been progressively explored for their potential in biomedical applications and particular as a contrast agent diagnostic imaging, magnetic drug delivery more recently tissue engineering applications. Considering the importance of having safe MNPs such applications, essential role iron bone remodelling, this study developed analysed novel biocompatible bioreabsorbable superparamagnetic nanoparticles, that avoid use poorly tolerated magnetite based...
Abstract: Three-dimensional (3D) in vitro models of cell culture aim to fill the gap between standard two-dimensional studies and vivo environment. Especially for neural tissue regeneration approaches where there is little regenerative capacity, these are important mimicking extracellular matrix providing support, allowing natural flow oxygen, nutrients, growth factors, possibly favoring regrowth. We have previously demonstrated that a new self-assembling nanostructured biomaterial, based on...
A bioinspired mineralization process was applied to develop biomimetic hybrid scaffolds made of (Fe2+/Fe3+)-doped hydroxyapatite nanocrystals nucleated on self-assembling collagen fibers and endowed with super-paramagnetic properties, minimizing the formation potentially cytotoxic magnetic phases such as magnetite or other iron oxide phases. Magnetic composites were prepared at different temperatures, effect this parameter reaction yield in terms degree, morphology, degradation,...
In the past few years, researchers have focused on design and development of three-dimensional (3D) advanced scaffolds, which offer significant advantages in terms cell performance. The introduction magnetic features into scaffold technology could innovative opportunities to control populations within 3D microenvironments, with potential enhance their use tissue regeneration or cell-based analysis. present study, fully biodegradable nanocomposite scaffolds for bone engineering, consisting a...
In case of degenerative disease or lesion, bone tissue replacement and regeneration is an important clinical goal. particular, nowadays, critical size defects rely on the engineering scaffolds that are 3D structural supports, allowing cellular infiltration subsequent integration with native tissue. Several ceramic hydroxyapatite (HA) high porosity good osteointegration have been developed in past few decades but they not solved completely problems related to defects. present study we a novel...
This work describes the development of an injectable nanocomposite system based on a chitosan thermosensitive hydrogel combined with liposomes for regenerative medicine applications. Liposomes good physicochemical properties are prepared and embedded within network. The resulting is able to provide controlled release content from liposomes, which interact cells be internalized. cellular uptake enhanced by presence coating, incubated hydrogels displayed higher cell compared alone....
A straightforward technique for functionalization of multiwalled carbon nanotubes (MWCNTs) with magnetite (Fe3O4) nanoparticles was developed. Iron oxide were deposited on MWCNT surfaces by a deposition–precipitation method using Fe3+/Fe2+ salts precursors in basic solution. The characterizations HRTEM, XRD, SEM/EDX, AAS and TPR analyses confirmed the successful formation magnetic iron surface. Fe3O4/MWCNT hybrid composites analysed vitro incubation mesenchymal stem cells 1, 3 7 days, either...
Doping of biocompatible nanomaterials with magnetic phases is currently one the most promising strategies for development advanced biomaterials. However, especially in case iron-doped hydroxyapatites, it not clear if features come merely from phases/ions used as dopants or complex mechanisms involving interactions at nanoscale. Here, we report an extensive chemical-physical and investigation three hydroxyapatite nanocrystals doped different iron species containing small no amounts maghemite...
Abstract The failure of the osteosarcoma conventional therapies leads to growing need for novel therapeutic strategies. lack specificity Cancer Stem Cells (CSCs) population has been recently identified as main limitation in current therapies. Moreover, traditional two-dimensional (2D) vitro models, employed drug testing and screening well study cell molecular biology, are affected by a poor vitro-in vivo translation ability. To overcome these limitations, this work provides two tumour...
The development of non-toxic and biodegradable magnetic nanoparticles (NPs) that can be easily functionalized with drugs or biomolecules employed, under fields, as targeted nano-carriers components scaffolds on-demand functionalities, is a big challenge in the biomaterials research. In present work, feasibility previously synthesized iron-doped superparamagnetic apatite (FeHA) NPs to bind then release anticancer drug doxorubicin (DOX) an applied low-frequency pulsed electromagnetic field...
Melanin is a multifunctional biological pigment that recently emerged as endowed with anti-inflammatory, antioxidant, and antimicrobial properties high potentialities in skin protection regenerative medicine. Here, biomimetic magnesium-doped nano-hydroxyapatite (MgHA) was synthesized decorated melanin molecules starting from two different monomeric precursors, i.e. 5,6-dihydroxyindole-2-carboxylic acid (DHICA) dopamine (DA), demonstrating to be able polymerize on the surface of MgHA...
Abstract The use of magnetism in tissue engineering is a very promising approach, fact magnetic scaffolds are able not only to support regeneration, but they can be activated and work like magnet attracting functionalized nanoparticles (MNPs) injected close the scaffold enhancing regeneration. This study aimed assess vivo biocompatibility osteointegrative properties novel scaffolds. Two hydroxyapatite/collagen (70/30 wt %) were magnetized with two different techniques: direct nucleation...
Superparamagnetic iron-substituted hydroxyapatite nanocrystals (FeHA) were used as a particulate emulsifier for the preparation of hybrid polymeric–inorganic materials by Pickering emulsion. As result, magnetic hollow micro-nanospheres (ranging from 2 μm to 500 nm) made polymeric shell poly(l-lactic) acid coated with FeHA have been prepared. Several composites containing different amounts inorganic phase loaded The amount strongly affected chemical-physical features spheres such size,...