A5006104247- Drug Solubulity and Delivery Systems
- Phytochemistry and biological activity of medicinal plants
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Bee Products Chemical Analysis
- Additive Manufacturing and 3D Printing Technologies
- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Phytochemistry Medicinal Plant Applications
- Inhalation and Respiratory Drug Delivery
- Essential Oils and Antimicrobial Activity
- Proteins in Food Systems
- Lipid metabolism and biosynthesis
- Microencapsulation and Drying Processes
- Natural Compound Pharmacology Studies
- Plant-Derived Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- RNA Interference and Gene Delivery
- Science and Education Research
- Contact Dermatitis and Allergies
- Agricultural and Food Sciences
- Cancer, Hypoxia, and Metabolism
University of Lisbon
2020-2023
University of Technology Sydney
2015-2020
University of Parma
2019
Universidade Federal do Rio Grande do Sul
2012-2019
National Council for Scientific and Technological Development
2016-2018
Universidade da Região da Campanha
2018
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2015
Drug delivery to the brain represents a challenge, especially in therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult exploit (CNS). In present work physico–chemical, mucoadhesive, and permeability-enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated chitosan for nose-to-brain administration were investigated. Lipid-core (LNCchit) different molecular weight (MW) prepared by novel...
Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such are extremely elusive via the conventional oral administration. The purpose present study was prepare and characterize physicochemical properties in vivo biodistribution simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration view an improved delivery brain.Chitosan, lecithin, different...
The influence of the composition and preparation method on sol-gel transition temperature (Tsol-gel) rheological response poloxamer-based formulations was determined. Manual more complex mechanical stirring were found to provide similar results. In addition, a linear dependence Tsol-gel poloxamer content observed in range concentrations analyzed, Poloxamer 407® concentration 18% selected. addition hyaluronic acid did not lead significant changes values. contrast, microparticles caused...
Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera vitamin E have been demonstrated be beneficial in formulations for wound healing. The aim of this work is develop evaluate polymeric films containing treat wounds caused by burns. Polymeric different quantities sodium alginate polyvinyl alcohol (PVA) were characterized their mechanical properties drug release. films, which produced, thin, flexible, resistant, suitable...
Lipid-based drugs are emerging as an interesting class of novel anticancer with the potential to target specific cancer cell metabolic pathways linked their proliferation and invasiveness. In particular, ω-3 polyunsaturated fatty acids (PUFA) derivatives such epoxides bioisosteres have demonstrated suppress growth promote apoptosis in triple-negative human breast cells MDA-MB-231. this study, 16-(4'-chloro-3'-trifluorophenyl)carbamoylamino]hexadecanoic acid (ClFPh-CHA), lipid derived from...
Aims: Lipid-core nanocapsules (LNCs) loaded with simvastatin (SV, SV-LNC) or lovastatin (LV, LV-LNC) were formulated for pulmonary administration. Methods: The LNC suspensions characterized physicochemically, their stability was evaluated, and drug delivery by the route tested in vitro. Results: LNCs had a particle size close to 200 nm, low polydispersity index, zeta potential around -20 mV. encapsulation efficiency high SV (99.21 ± 0.7%) but LV (20.34 1.2%). release from slower than it...
LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION.In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation.Mean particle size ranged from 105 to 153 nm and negative zeta potentials obtained all theosphere formulations.Atomic force microscopy images confirmed spherical shape of theospheres.The HPLC method used determine dapsone-loaded was selective, linear, exact precise.The...
Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced hot-melt extrusion printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect infill geometry (cross, star, grid) on drug content release are reported.
Lipid-based drugs are emerging as an interesting class of novel anticancer with the potential to target specific cancer cell metabolic pathway linked their proliferation and invasiveness. In particular, ω−3 polyunsaturated fatty acids (PUFA) derivatives such epoxides bioisosteres have demonstrated suppress growth promote apoptosis in triple-negative human breast cells MDA-MB-231. this study 16-(4’-chloro-3’-trifluorophenyl)carbamoylamino]hexadecanoic...
The manufacture of medicines on demand for a particular patient, at the point care, may be achieved via 3D printing, improving therapeutic outcomes, medication adherence and patient safety. Tablets are often printed using combination hot-melt extrusion fused deposition modelling. In this work, paracetamol-loaded hydroxypropylcellulose filaments were produced; their extrudability printability aided by plasticizer lubricant. For printability, 11% humidity was ideal storage condition up to 6...