A5017321383- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Phytochemistry Medicinal Plant Applications
- Advancements in Transdermal Drug Delivery
- Agricultural and Food Sciences
- Microencapsulation and Drying Processes
- Analytical Chemistry and Chromatography
- Healthcare Regulation
- Clinical Nutrition and Gastroenterology
- Analytical Methods in Pharmaceuticals
- Nerve injury and regeneration
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
- Mesenchymal stem cell research
- Public Health in Brazil
- Health, Nursing, Elderly Care
- Genetics, Aging, and Longevity in Model Organisms
- Congenital Anomalies and Fetal Surgery
- Nanoparticle-Based Drug Delivery
- Congenital Diaphragmatic Hernia Studies
- Curcumin's Biomedical Applications
- Polymer Surface Interaction Studies
- Antibiotics Pharmacokinetics and Efficacy
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical studies and practices
Universidade Federal do Pampa
2015-2023
Universidade Federal do Rio Grande do Sul
2004-2023
Universidade de Passo Fundo
2011
Universidade Federal de Santa Maria
2003-2004
The hemocompatibility of nanoparticles is critical importance for their systemic administration as drug delivery systems. Formulations lipid-core nanocapsules, stabilized with polysorbate 80-lecithin and uncoated or coated chitosan (LNC LNC-CS), were prepared characterized by laser diffraction (D[4,3]: 129 134 nm), dynamic light scattering (119 nm 133 nanoparticle tracking (D50: 124 139 nm) particle mobility (zeta potential: -15.1 mV +9.3 mV) analysis. In vitro studies carried out mixtures...
Based on the structure of polymeric nanocapsules containing a lipid-dispersed core composed caprylic/capric trygliceride (CCT) and sorbitan monostearate (SM), we hypothesized that varying component concentrations drug release kinetic could be modulated. Our objective was also to determine parameters which were responsible for controlling kinetics. The prepared by interfacial deposition poly(epsilon-caprolactone). Interfacial hydrolysis indomethacin ester (IndOEt) used simulate sink condition...
Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation nanoemulsions is considered a promising strategy to facilitate applicability of these natural compounds and potentiate actions. These formulations offer several advantages for topical systemic delivery cosmetic agents including controlled droplet size, protection vegetable oil photo, thermal volatilization instability ability dissolve stabilize lipophilic drugs. For...
The aim of this work was to develop and characterize clozapine loaded polysorbate-coated polymeric nanocapsules assess their toxicity in Caenorhabditis elegans, an invertebrate animal model. Formulations were prepared by nanoprecipitation method characterized particle size, zeta potential, pH, drug loading, entrapment efficiency vitro release. All presented diameter around 140 nm, pH slightly acid negative potential. In studies showed biphasic release from with decreasing the rate on...
The aim of the present work was to verify in vivo capacity pantoprazole-loaded microparticles protect gastric mucosa against ulcer formation and evaluate their stability under accelerated conditions.Pantoprazoleloaded were prepared by spray-drying pilot scale, using Eudragit ® S100 as polymer.Transparent glass vials containing drug-loaded stored for 6 months at 40°C 75% RH.Photostability tested UVA light.Ulcers induced oral administration absolute ethanol rats.Sodium bicarbonate solution,...
Microparticles of poly(ε-caprolactone) and its blend with Eudragit® S100 were prepared by emulsion/solvent evaporation technique to provide controlled release gastro-resistance for an acid labile drug. This drug was sodium pantoprazole, a proton pump inhibitor. Both formulations successfully prepared, but only the microparticles capable stabilizing in medium. Furthermore, this formulation showed vivo protection stomachs against ulceration caused ethanol rats. These tabletted, tablets...
The ethanolic extract obtained from purple pitanga fruit (Eugenia uniflora - PPE) has been previously described by its potential to reduce lipid accumulation in vitro. In this study, we aimed study vivo using Caenorhabditis elegans as animal model. Considering the low pH of extract, hydrophilic characteristic, absorption medium where worms are cultivated and need a chronic exposure solid medium, have loaded liposomes with PPE investigated for oral administration. Following 48 h PPE-loaded on...
Neste estudo é apresentado um modelo experimental de defeito agudo em nervo periférico para avaliação da regeneração nervosa mediante técnica tubulização associada à inoculação células-tronco autólogas medula óssea. Foram utilizados 12 coelhos Nova Zelândia albinos, submetidos secção bilateral e ao afastamento 5mm do tibial posterior reparo utilização câmara silicone. Internamente prótese esquerdo todos os animais, foram inoculadas óssea, coletadas a partir úmero. Como grupo controle (nervo...
Excessive exposure to the sun during childhood is strongly associated with development of skin cancer in future. The only way prevent protect against ultraviolet radiation, which can be achieved through strategic awareness and adolescence.The aim this work was evaluate impact educational activities for rural urban students promote use sunscreens cancer.This study carried out (9-12 years) (n=70) schools Rio Grande do Sul state, Brazil. interventions were lectures games. strategy evaluated...
Simultaneous estimation of paclitaxel and curcumin in nano-formulation: Stability analysis drugs, optimization validation HPLC methodJoyceline Praveena, Bharath Raja Guru
LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION.In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation.Mean particle size ranged from 105 to 153 nm and negative zeta potentials obtained all theosphere formulations.Atomic force microscopy images confirmed spherical shape of theospheres.The HPLC method used determine dapsone-loaded was selective, linear, exact precise.The...
Validation of analytical method by HPLC for determination dapsone in polymeric nanocapsules based on crude rice brain oilLetícia Marques Colomé,Gaya Mengue Freitas,Janaina de Medeiros Bastiani,Thais Carla Brussulo Pereira,Lisiane Bajerski,Eduardo André Bender,Sandra Elisa Haas