A5066640664- Oral microbiology and periodontitis research
- Education Pedagogy and Practices
- Endodontics and Root Canal Treatments
- Dental Health and Care Utilization
- Education and Digital Technologies
- Dental Research and COVID-19
- Bone health and treatments
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Photodynamic Therapy Research Studies
- Drug-Induced Ocular Toxicity
- Linguistics and Education Research
- Proteins in Food Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Dental Anxiety and Anesthesia Techniques
Universidade Franciscana
2011-2024
Aims: Lipid-core nanocapsules (LNCs) loaded with simvastatin (SV, SV-LNC) or lovastatin (LV, LV-LNC) were formulated for pulmonary administration. Methods: The LNC suspensions characterized physicochemically, their stability was evaluated, and drug delivery by the route tested in vitro. Results: LNCs had a particle size close to 200 nm, low polydispersity index, zeta potential around -20 mV. encapsulation efficiency high SV (99.21 ± 0.7%) but LV (20.34 1.2%). release from slower than it...
Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment rats. While our results were promising, we needed to evaluate potential toxicity nanoparticles themselves. This study aimed compare biochemical and hematological parameters adult Wistar rats receiving LNC or SV-LNC those low doses crystals dispersed a saline solution over 45 days. We discovered that SV-LNC, which are both nanometers size...