A5005309075- Radiopharmaceutical Chemistry and Applications
- Bone health and osteoporosis research
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Mesenchymal stem cell research
- Bone fractures and treatments
- Advanced Radiotherapy Techniques
- Respiratory Support and Mechanisms
- Liver physiology and pathology
- Abdominal Surgery and Complications
- Cell Adhesion Molecules Research
- Advanced Drug Delivery Systems
- Indoor Air Quality and Microbial Exposure
- Pleural and Pulmonary Diseases
- Traditional and Medicinal Uses of Annonaceae
- Ultrasound Imaging and Elastography
- Air Quality Monitoring and Forecasting
- Drug Transport and Resistance Mechanisms
- Dental Radiography and Imaging
- Occupational and environmental lung diseases
- Vector-borne infectious diseases
- Neonatal Respiratory Health Research
- Phytochemistry Medicinal Plant Applications
- Effects of Radiation Exposure
Universidade do Estado do Rio de Janeiro
2015-2025
Universidade Federal do Rio de Janeiro
2014-2022
Hospital Universitário Clementino Fraga Filho
2011-2021
National Institute of Science and Technology for Structural Biology and Bioimaging
2018
Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such are extremely elusive via the conventional oral administration. The purpose present study was prepare and characterize physicochemical properties in vivo biodistribution simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration view an improved delivery brain.Chitosan, lecithin, different...
AbstractAbstract Different combinations of tidal volume and positive end-expiratory pressure (PEEP) were used to create a range driving pressures in rat model acute respiratory distress syndrome due tracheal instillation endotoxin for 24 h. Low transpulmonary was associated with alveolar collapse high hyperinflation. The combination 6 ml/kg predicted body weight the lowest PEEP maintain oxygenation normal minimized ventilator-induced lung injury even presence collapse. Supplemental Digital...
This study evaluated the antibacterial and antibiofilm activities of methanolic extracts from invasive corals Tubastraea coccinea tagusensis a synthesized alkaloid (APL01). The activity was by macrodilution microdilution methods using 16 bacterial strains. in Staphylococcus aureus biofilm inhibition assay. cytotoxic potential also analyzed human carcinoma cell lines HEp-2 Caco-2. All samples were capable interfering with growth strains, highlighted extract T. coccinea, which inhibited...
Administration of bone marrow mononuclear cells (BMMCs) modulates lung inflammation and fibrosis in experimental silicosis. However, no studies have evaluated whether silicosis affects the efficacy autologous BMMCs treatment. We hypothesized that obtained from healthy or silicotic mice may improve function, but they might affect inflammatory fibrotic processes differently C57BL/6 were randomly divided into control (C) (SIL) groups. Mice SIL group instilled with silica particles...
Brazilian flora includes numerous species of medicinal importance that can be used to develop new drugs. Plant tissue culture offers strategies for conservation and use these allowing continuous production plants bioactive substances. Annona mucosa has produced substances such as acetogenins alkaloids exhibit antimicrobial activities. The widespread antibiotics led an increase in multidrug-resistant bacteria, which represents a serious risk infection. In view this problem, the aim work was...
Abstract Bone mineral density is an important parameter for the diagnosis of bone diseases, as well predicting fractures and treatment monitoring. Thus, aim present study was to evaluate potential Quantitative Ultrasound (QUS) monitor changes after calcium, phosphorus, magnesium loss in rat femurs vitro during a demineralization process. Four quantitative ultrasound parameters were estimated from surface echoes eight femur diaphysis rats. The echo signals acquired decalcification process by...
The cramoll 1,4 is a well-studied lectin. However, few studies about its biodistribution have been done before. In this study, we radiolabeled the cramol with Tc-99m and analyzed biodistribution. results showed that has an abnormal uptake by bowel reflections on clearance mechanism.
This work evaluates the relationship between ultrasonic reflection and bone density from fourteen cylindrical bovine cortical samples (3.0-cm thick).Twenty US signals per sample were acquired along surface (2.0-mm step). The Integrated Reflection Coefficient (IRC) each signal was compared to Quantitative Computed Tomography (QCT).Seven IRC QCT curves presented Pearson's Correlation R-values above 0.5. For weak correlation curves, showed similar trends in several segments.IRC sensitive...
Doxorubicin (DOX) is a potent chemotherapeutic agent used as the first-choice drug in treating different types of cancer, such leukemia, lymphoma, and breast among others. However, development multidrug resistance represents significant obstacle to successful treatment tumors. In this study, we assessed whether labeled DOX could be uptaken by susceptible multidrug-resistant cell lines tumors vivo animals. The efficiency labeling was maintained at around 90% work. To evaluate effect 99mTc-DOX...
Radiation-induced liver disease (RILD) remains a major problem resulting from radiotherapy. In this scenario, immunotherapy with granulocyte colony-stimulating factor (G-CSF) arises as an attractive approach that might improve the injured liver. Here, we investigated G-CSF administration's impact before and after irradiation exposure using association of alcohol consumption local to induce model in C57BL/6 mice. Male female mice were submitted previous alcohol-induced injury protocol water...
Budget cuts among other factors undermine the use of state-of-the-art equipment by many research groups. This doesn't mean that their scientific data are not reliable or top-notch. Resort to adaptations is a recurrent need in reality. The aim this study was assess whether scintigraphy with 99mTcO4 effective evaluating functionality thyroid grafts after cryopreservation rats. 24 rats were randomly distributed into 3 groups: Control Group (CG), without surgical procedure, Hypothyroidism (HTG),...
The objective of this study was to evaluate spatial resolution and the influence different reconstruction methods in a FLEX Triumph ™ Pre-Clinical Imaging System images applied mice C57BL6 dosimetry new radiopharmaceuticals development for humans use. CT SPECT were obtained from homemade phantom containing four spheres with diameters (d) simulating iodine-accumulating injuries at University Hospital (HU / UFRJ). reconstructed filtered back projection method (FBP) partial volume effect...
Background: Laparoscopic surgery with pneumoperitoneum increases respiratory system elastance due to the augmented intra-abdominal pressure. We aim evaluate which extent positive end-expiratory pressure (PEEP) is able counteract abdominal hypertension preventing progressive lung collapse and how rib cage influences PEEP effect. Methods: Forty-four Wistar rats were mechanically ventilated randomly assigned into three groups: control (CTRL), (PPT) restricted (PPT-RC). A pressure-volume (PV)...
ABSTRACT This study aimed to determine the biokinetic model for Ixolaris labelled with 99mTc radiotracer in mice by means of an imaging dosimetry method estimate absorbed and effective doses resulting from diagnosis melanoma metastases humans. C57BL6 induced animals cell line B16-F10 murine were tested. It was determined Single Photon Emission Tomography Computed (SPECT) images a latency period 15 21 days development lung metastasis mice. The 99mTc-Ixolaris radiopharmaceutical intravenously...
This work aims to compare SPECT (Single Photon Emission Tomography Computed) and planar modalities as the most efficient methodology perform dosimetry by molecular imaging. Twenty-one male C57BL6 mice induced with murine melanoma cell line B16-F10, administered 131I-Ixolaris were used for therapy. The procedures applied them followed standards described use of experimental animals, duly approved National Council Animal Experimentation Control (CONCEA from Federal University Rio de Janeiro....
Ixolaris is a tick salivary protein that binds to Factor Xa or X as scaffold for inhibition of the Tissue (TF)/Factor VIIa (FVIIa). TF not normally expressed in cells are direct contact with blood. However, abnormally under several pathological conditions, including inflammation, infectious diseases and cancer. It known decades risk factor metastasis, mouse models, drives metastasis coagulation-dependent manner. For these reasons, has recently been described potential target can be exploited...