A5030332561- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Microencapsulation and Drying Processes
- Nanoparticle-Based Drug Delivery
- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Protein purification and stability
- Pharmaceutical studies and practices
- Lipid Membrane Structure and Behavior
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Medieval Iberian Studies
- RNA Interference and Gene Delivery
- Dermatology and Skin Diseases
- Polysaccharides Composition and Applications
- Pneumonia and Respiratory Infections
- Galician and Iberian cultural studies
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Helicobacter pylori-related gastroenterology studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Intravenous Infusion Technology and Safety
University of Ferrara
2015-2024
University of Milan
2014-2022
Politecnico di Milano
2010
University of Parma
2003-2005
Massachusetts Institute of Technology
2004
University of Padua
1985-1987
Drug delivery to the brain represents a challenge, especially in therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult exploit (CNS). In present work physico–chemical, mucoadhesive, and permeability-enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated chitosan for nose-to-brain administration were investigated. Lipid-core (LNCchit) different molecular weight (MW) prepared by novel...
Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility reaching therapeutically relevant levels exogenous molecules in body is strongly reliant on ability nanoparticles overcome biological barriers. In this work, three paradigmatic nanoformulations vehiculating poorly soluble model drug simvastatin were addressed: (i) hybrid lecithin/chitosan (LCNs), (ii) polymeric poly-ε-caprolactone nanocapsules stabilized with...
Nasal administration has been proposed as a potential approach for the delivery of drugs to central nervous system. Ribavirin (RBV), an antiviral drug potentially useful treat viral infections both in humans and animals, previously demonstrated attain several brain compartments after nasal administration. Here, powder formulation form agglomerates comprising micronized RBV spray-dried microparticles containing excipients with absorption enhancing properties, i.e. mannitol, chitosan,...
There is interest in developing prolonged duration local anesthesics. Here we examine whether tetrodotoxin (TTX) can be used to prolong the block from bupivacaine microspheres with and without dexamethasone. Rats received sciatic nerve blocks 75 mg of containing 0.05% (w/w) TTX, 50% and/or 0.1% TTX were also tested. The carrier fluid contained 1:100,000 epinephrine. Nociceptive motor blockade hindpaw quantified. Nerves adjacent muscles harvested 2 weeks after injection for histological...
In the field of nasal delivery, one most fascinating applications is delivery drugs directly to central nervous system bypassing blood brain barrier. This approach would provide a series benefits, such as dose lowering and direct targeting potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored administration insulin for treatment Alzheimer’s disease, with promising results. The use nanomedicines could further options making...
Quercetin (Que) is a flavonoid associated with high oxygen radical scavenging activity and potential neuroprotective against Alzheimer's disease. Que's oral bioavailability limited by its low water solubility extended peripheral metabolism; thus, nasal administration may be promising alternative to achieve effective Que concentrations in the brain. The formation of Que–2-hydroxypropylated−β-cyclodextrin (Que/HP-β-CD) complexes was previously found increase molecule's stability aqueous media....