A5064918320- Drug Solubulity and Delivery Systems
- Saffron Plant Research Studies
- Lipoproteins and Cardiovascular Health
- Drug-Induced Hepatotoxicity and Protection
- Silymarin and Mushroom Poisoning
- Clay minerals and soil interactions
- Berberine and alkaloids research
- Inhalation and Respiratory Drug Delivery
- Mine drainage and remediation techniques
- Medicinal Plants and Bioactive Compounds
- Analytical Chemistry and Chromatography
- Protein purification and stability
- Atherosclerosis and Cardiovascular Diseases
- Cryospheric studies and observations
- Iron oxide chemistry and applications
- Free Radicals and Antioxidants
- NMR spectroscopy and applications
- Biochemical effects in animals
- Renal and related cancers
- Neurological Disease Mechanisms and Treatments
- Advanced Drug Delivery Systems
- CO2 Sequestration and Geologic Interactions
- Heavy Metals in Plants
- Advancements in Transdermal Drug Delivery
- Epigenetics and DNA Methylation
National and Kapodistrian University of Athens
2015-2024
Menlo School
2018
National Technical University of Athens
1999
Abstract The rising costs of climate change merit serious evaluation potential restoration solutions. highest rate in is observed the Arctic where summer ice diminishing at an accelerated rate. loss sea increases radiative forcing and contributes to global warming. Restoring reflectivity could be a powerful lever help effort limit warming 1.5°C. Polar should considered planning 1.5°C pathways. In this paper, novel localized surface albedo modification technique presented that shows promise...
Abstract Objectives To prepare a lyophilized saffron aqueous extract (SFE) and determine its chemical profile serum tissue pharmacokinetics after intravenous oral administration to C57/Bl6J mice. Methods Lyophilized SFE was prepared, characterized using semi-preparative HPLC NMR analysis, stability studies at room temperature, quantified for crocin content with an HPLC-PDA method. After of (60 mg/kg, reconstituted water injection) mice, crocetin (derived from in vivo hydrolysis) levels...
Purpose: We investigated the hepatoprotective effect of Silibinin (SLB) to ischemia-reperfusion (I/R) rat model, by evaluating histological expression tissue markers Fas/FasL, HMGB-1 and CD45, SLB pharmacokinetics. Methods: Seventy-three Wistar-type male rats were randomized in 11 groups: Sham control group (open-close laparotomy); four I/R groups (laparotomy, 45 min vascular occlusion, reperfusion, euthanasia after 60, 120, 180, 240 min); (Si) IV administration SLB, two pharmacokinetics...
Renin–angiotensin aldosterone system inhibitors are for a long time extensively used the treatment of cardiovascular and renal diseases. AT1 receptor blockers (ARBs or sartans) act as antihypertensive drugs by blocking octapeptide hormone Angiotensin II to stimulate receptors. The drug candesartan (CAN) is active metabolite cilexetil (Atacand, CC). Complexes with 2-hydroxylpropyl-β-cyclodextrin (2-HP-β-CD) were characterized using high-resolution electrospray ionization mass spectrometry...
Background: Remote kidney damage is a sequel of hepatic ischemia–reperfusion (I/R) injury. Silibinin the main ingredient milk thistle plant seed extract with known antioxidant and hepatoprotective activity. Our study investigates nephroprotective potential intravenously administered silibinin, as lyophilized SLB-hydoxypropyl-beta-cyclodextrin product, in I/R Material methods: 63 Wistar rats were divided into three groups: Sham (virtual intervention); Control (45 min ischemia reperfusion);...
Background:To evaluate the impact of atorvastatin discontinuation on progression and stability atherosclerotic plaques in a valid animal model atherosclerosis. Methods:Seventy ApoE−/− male mice fed with high-fat diet were randomly assigned into: (1) long-term intervention groups: (i) ATL, received for 12 weeks, (ii) CO-12W, control vehicle (iii) ATW-6W, 6 weeks which was withdrawn another weeks. (2) Short-term ATS CO-6W, receiving ATW-3D, ATW-7D, 3 days 7 days, respectively. Daily dosage 20...
Cyclodextrins are pliable platforms that have served to optimize the pharmaceutic profile of numerous compounds and enhance stability natural food additives. Caffeic rosmarinic acid products with proven health benefits, though their full therapeutic potential has not been exploited. To profile, we developed cyclodextrin-based formulates unveiled thermodynamic structural principles. The complexes' stoichiometry was determined by ESI-MS. Solid-state liquid NMR spectroscopy revealed...
AbstractAbstractBased on the principle of thermodynamic equilibrium, solubility curves trivalent iron and aluminum at 25 °C are presented used as a guide for prediction understanding chemistry these metal ions in oxalic acid solutions. The present paper proposes framework derived from equilibrium data that was formulated to qualitatively correlate predict species distribution Fe3+ − Al3+ H2C2O4 H2O system concentrations varying between 1 10−6 M. also advocates use graphical representations...
Abstract Irbesartan (IRB) exerts beneficial effects either alone or in combination with other drugs on numerous diseases, such as cancer, diabetes, and hypertension. However, due to its high lipophilicity, IRB does not possess the optimum pharmacological efficiency. To circumvent this problem, a drug delivery system 2‐hydroxypropyl‐β‐cyclodextrin (2‐HP‐β‐CD) was explored. The 1:1 complex between 2‐HP‐β‐CD identified through ESI QTF HRMS. Dissolution studies showed higher dissolution rate of...
Background: Rising antimicrobial resistance has led to a revived interest in inhaled colistin treatment the critically ill patient with ventilator-associated respiratory infection (VARI). Nebulization via vibrating mesh nebulizers (VMNs) is considered current standard-of-care, yet use of generic jet (JNs) more widespread. Few data exist on intrapulmonary pharmacokinetics when administered through VMNs, while there complete paucity regarding JNs. Methods: In this study, 18 VARI patients who...
Aspirin is an historic blockbuster product, and it has been proposed in a wide range of formulas. Due to exacerbation risks, the pulmonary route seldom considered as alternative conventional treatments. Only recently, owing overt advantages, inhalable acetylsalicylic acid dry powders (ASA DPI) began be option. In this work, we developed novel highly performing ASA DPI using nano spray-drying technique leucine excipient evaluated its pharmacokinetics compared with oral administration. The...
Aim: Complementary effects of dabigatran etexilate (DE), exercise training (ET) and combination (DE+ET) on the development composition atherosclerotic lesions in diabetic apoE knockout (apoE-/-) mice. Methods: In 48 male apoE-/- mice, streptozotocin (STZ) was induced for 5 consecutive days. Mice received figh-fat diet (HFD) 8 weeks were randomized into 4 groups (1.Control/CG, 2.DEG: HFD with DE, 3.ETG: ET treadmill, 4.DE+ETG: Combination DE treatment). At end 8th week, all mice euthanatized...
Aim: To determine the complementary effects of dabigatran etexilate (DE), exercise training (ET), and combination (DE + ET) on development stability atherosclerotic lesions in diabetic apoE knockout (apoE-/-) mice. Methods: In 48 male apoE-/- mice, streptozotocin (STZ) was induced for 5 consecutive days. Mice received a high-fat diet (HFD) 8 weeks then were randomized into four groups (1. Control/CG, 2. DEG: HFD with DE, 3. ETG: ET treadmill, 4. DE treatment). At end eighth week, all mice...