A5060938385- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Olfactory and Sensory Function Studies
- Proteins in Food Systems
- Protein Interaction Studies and Fluorescence Analysis
- Enzyme Catalysis and Immobilization
- Inflammatory mediators and NSAID effects
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- Cardiac electrophysiology and arrhythmias
- Free Radicals and Antioxidants
- Silymarin and Mushroom Poisoning
- Flavonoids in Medical Research
- Cardiac Arrhythmias and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Analytical Methods in Pharmaceuticals
- Nanoparticle-Based Drug Delivery
- Asthma and respiratory diseases
- Plant-based Medicinal Research
- Curcumin's Biomedical Applications
- Antiplatelet Therapy and Cardiovascular Diseases
National and Kapodistrian University of Athens
2020-2025
Trinity College Dublin
2024
Ropinirole is a non-ergolinic dopamine agonist used to manage Parkinson's disease and it characterized by poor oral bioavailability. This study aimed design develop advanced drug delivery systems composed of poloxamer 407, non-ionic surfactant (Tween 80), cyclodextrins (methyl-β-CD or hydroxy-propyl-β-CD) for possible brain targeting ropinirole after nasal administration the treatment disease. The hybrid were formed thin-film hydration method, followed an extensive physicochemical...
Quercetin (Que) is a flavonoid associated with high oxygen radical scavenging activity and potential neuroprotective against Alzheimer's disease. Que's oral bioavailability limited by its low water solubility extended peripheral metabolism; thus, nasal administration may be promising alternative to achieve effective Que concentrations in the brain. The formation of Que–2-hydroxypropylated−β-cyclodextrin (Que/HP-β-CD) complexes was previously found increase molecule's stability aqueous media....
Abstract Background Minocycline has made a comeback in the drug armamentarium as treatment option for infections due to Acinetobacter baumannii. Although, it been launched 1960s, scarce pharmacokinetic studies have published. This open-label, prospective clinical study was conducted critical ill patients with documented infections, mainly VAP-associated pneumonia, attributed extensively-drug or pan-drug resistant baumannii, susceptible-or intermediate susceptible minocycline strains, treated...
Donepezil (DH), a selective acetylcholinesterase inhibitor, is widely used to manage symptoms of mild moderate Alzheimer's disease by enhancing cholinergic neurotransmission and preventing acetylcholine breakdown. Despite the effectiveness oral formulations, extensive hepatic metabolism low systemic bioavailability have driven search for alternative delivery systems. This study focuses on nasal as non-parenteral substitute, utilizing hydroxypropyl methylcellulose (HPMC) its mucoadhesive...
Abstract Objectives Multidrug-resistant Acinetobacter baumannii (MDR-A. baumannii) has become an emerging pathogen, causing ventilator-associated pneumonia (VAP), with limited treatment options available. MIN re-emerged as a potential option for MDR pathogens. However, evidence regarding pharmacokinetic properties in critically ill patients is scarce and primarily to IV administration. To address the knowledge gap regions where unavailable, prospective, open-label study was conducted...
The objective and novelty of the present study is development optimization innovative nasal film Donepezil hydrochloride (DH) for potential use in Alzheimer’s disease. Hydroxypropyl-methyl-cellulose E50 (factor A) films, with Polyethylene glycol 400 as plasticizer B), Methyl-β-Cyclodextrin, permeation enhancer C), were prepared characterized vitro ex vivo. An experimental design was used to determine effects selected factors on profile DH through rabbit mucosa (response 1),...
Quercetin (QUE) is a well-known natural product that can exert beneficial properties on human health. However, due to its low solubility bioavailability limited. In the present study, we examine whether formulation with two cyclodextrins (CDs) may enhance pharmacological profile. Comparative interaction studies of quercetin 2-hydroxyl-propyl-β-cyclodextrin (2HP-β-CD) and 2,6-methylated cyclodextrin (2,6Me-β-CD) were performed using NMR spectroscopy, DFT calculations, in silico molecular...
The simultaneous administration of three antiplatelet agents has been proposed as an efficient strategy for the secondary prevention atherothrombotic events and is included in European guidelines. However, this presented increased risk bleeding; therefore, identification new agents, with improved efficacy diminished side effects, great importance. In silico studies, UPLC/MS Q-TOF plasma stability, vitro platelet aggregation experiments, pharmacokinetic studies were exploited. present study,...
Intranasal delivery is a non-invasive mode of administration, gaining popularity due to its potential for targeted the brain. The anatomic connection nasal cavity with central nervous system (CNS) based on two nerves: olfactory and trigeminal. Moreover, high vasculature respiratory area enables systemic absorption avoiding possible hepatic metabolism. Due these physiological peculiarities cavity, compartmental modeling formulation considered demanding process. For this purpose, intravenous...
Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties ascribed to its ability bind free radicals and inactivate them. However, low solubility compound along inadequate absorption after oral administration limit beneficial effects. Que’s complexation two different cyclodextrin (CD) derivatives (hydroxypropyl-β-CD methyl-β-CD) via neutralization/lyophilization method has been found improve physicochemical properties. Moreover, blends lyophilized powders...
Nasal drug delivery in rodents is a challenging procedure, especially for brain targeting, as the position of material nasal cavity determines success administration method. The objective this study was to assess novel intranasal technique nose-to-brain biodegradable films. method performed C57BL/6 ( n = 10; age, 8 wk) under inhaled sevoflurane. Twenty-four gauge catheters were used procedure. Hydroxypropyl methyl-cellulosebased film formed lumen catheter and then delivered into mouse...
Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of clinically approved drug Histochrome®. EchA currently only available in form an isotonic solution its di- and tri-sodium salts due to poor water solubility sensitivity oxidation. Electrospun polymeric nanofibers have lately emerged as promising carriers capable improving dissolution bioavailability drugs with limited solubility. In current study, urchins genus Diadema collected...
Aspirin is an historic blockbuster product, and it has been proposed in a wide range of formulas. Due to exacerbation risks, the pulmonary route seldom considered as alternative conventional treatments. Only recently, owing overt advantages, inhalable acetylsalicylic acid dry powders (ASA DPI) began be option. In this work, we developed novel highly performing ASA DPI using nano spray-drying technique leucine excipient evaluated its pharmacokinetics compared with oral administration. The...
Hybrid PEO- b -PCL/Tween 80/cyclodextrin systems: physicochemical and morphological characterization, in vitro release studies.