A5063216069- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Advancements in Transdermal Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Surfactants and Colloidal Systems
- Advanced Drug Delivery Systems
- thermodynamics and calorimetric analyses
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Proteins in Food Systems
- Computational Drug Discovery Methods
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Plant Toxicity and Pharmacological Properties
- Supramolecular Self-Assembly in Materials
- Drug Solubulity and Delivery Systems
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
National and Kapodistrian University of Athens
2015-2024
International Hellenic University
2024
University of Patras
2005-2016
University of Peloponnese
2015
National Hellenic Research Foundation
2001-2012
Academy of Athens
2005
University of Crete
2004
KU Leuven
2001
Rega Institute for Medical Research
2001
Université Paris Cité
1990-1994
Food nanotechnology involves the utilization of nanocarrier systems to stabilize bioactive materials against a range environmental and chemical changes as well improve their bioavailability. Nanoliposome technology presents exciting opportunities for food technologists in areas such encapsulation controlled release materials, enhanced bioavailability, stability, shelf-life sensitive ingredients. Liposomes nanoliposomes have been used industry deliver flavors nutrients and, more recently,...
Abstract Gradient (or pseudo‐diblock) copolymers were synthesized from 2‐methyl‐2‐oxazoline and 2‐phenyl‐2‐oxazoline monomer mixtures via cationic polymerization. The self‐assembling properties of these biocompatible gradient in aqueous solutions investigated, an effort to use the produced nanostructures as nanocarriers for hydrophobic pharmaceutical molecules. Dynamic static light scattering well AFM measurements showed that assemble different supramolecular (spherical micelles, vesicles...
Abstract Therapeutic targeting of tumor cells with drug nanocarriers relies upon successful interaction membranes and efficient cell internalization. A further consideration is that engineered nanomaterials should not damage healthy tissues contact. critical factor in this process the external coating delivery nanodevices. Using silico, vitro vivo studies, we show for first time magnetic nanoparticles coated polyarabic acid have superior imaging, therapeutic, biocompatibility properties. We...
In this work, we report on the self assembly behavior and stability studies of mixed amphiphilic nanosystems consisting DPPC (dipalmitoylphosphatidylcholine) poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) block copolymer in HPLC-grade water, phosphate buffer saline (PBS) fetal bovine serum (FBS). These are sterically stabilized nanovectors can be utilized as chimeric advanced Drug Delivery nano Systems (aDDnSs) with stealth properties. A gamut light scattering techniques (static,...
The aim of the present study is to investigate interactions between liposomes and proteins evaluate role liposomal lipid composition concentration in formation protein corona. Liposomes composed 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or hydrogenated soybean phosphatidylcholine (HSPC) with 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (DPPG), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] (DPPE-PEG 3000), cholesterol...
Exosomes are naturally derived information carriers that present interest as drug delivery systems. However, their vague cargo and isolation difficulties hinder use in clinical practice. To overcome these limitations, we developed exosome-like nanoparticles, consisted of the main lipids exosomes, using two distinct methods: thin-film hydration 3D-printed microfluidics. Our novel microfluidic device, fabricated through digital light processing printing, demonstrated a favorable architecture...
Nine labdane type diterpenes isolated from the plant Cistus creticus subsp. and resin "Ladano" which is excreted on surface of leaves stems this plant, were examined for their in vitro cytotoxic activity against 14 human leukemic cell lines. Compound 1, (13E)-labd-13-ene-8α,15-diol, exhibited 13 lines tested, while compound 2, (13E)-labd-7,13-dienol, was active only HL60 cells. Further 1 its effect uptake [3 H]-thymidine as a marker DNA synthesis.
Seven labdane-type diterpenoids were isolated from the leaves of Cistus incanus subsp. creticus; their structures established by spectroscopic means. All compounds tested in vitro for cytotoxicity against three cell line systems: KB, P-388; and NSCLC-N6. Their antibacterial anti-fungal activities Staphylococcus aureus, epidermidis, Pseudomonas aeruginosae, Enterobacter cloacae, Escherichia coli, Klebsiella pneumonia, Torulopsis glabrata, Saccharomyces cerevisiae, Candida albicans as well.
Current efforts toward improving the effectiveness of drug therapy are increasingly relying on drug-targeting strategies to effectively deliver bioactive molecules their molecular targets. Pharmaceutical nanocarriers represent a major tool this aim, and our have been directed achieving nanocarrier-mediated subcellular delivery with mitochondria as primary target. Meeting need for specific is essential realizing full potential many poorly soluble anticancer drugs. In article, we report that...