Gentiopicroside (GPS) is a leading component of several plant species from the Gentianaceae botanical family. As compound with plenty biological activities and herbal drugs, GPS has an important role in regulation physiological processes humans. The results recently published scientific studies underline meaningful this molecule as active factor metabolic pathways mechanisms, which may have influence treatment different diseases, including digestive tract disorders, malignant changes,...

Cymbidium is one of the most popular genera in Orchidaceae family, commercialized either as loose flowers or potted plants floriculture worldwide. The non-marketable parts are typically discarded (e.g., unsuitable flowers, leaves, pseudobulbs, roots), generating an enormous quantity unutilized biomass. above by-products were studied through phytochemical analysis and investigated for their dermo-cosmetic potential. initial antioxidant, anti-tyrosinase, anti-elastase, anti-collagenase assays...

Secoiridoids is the prominent chemical class of olive oil polar constituents and are characterized by significant biological properties. They abundant in different forms relatively high concentrations compared to other components, while prone oxidation due their motif. In recent years, oxidized derivatives secoiridoids have been reported, either as natural or components which gradually formed all stages its production storage. The mono-oxidized oleocanthal oleacein named respective acids...

Endophytic microorganisms (EMs) have recently attracted interest for applications in plant protection, mainly due to their bioactive compound-producing capacity. Therefore, we underwent the task of isolating olive tree EMs and investigating bioactivity against devastating pathogen Colletotrichum acutatum. Several were isolated; however, Bacillus sp. PTA13 isolate exhibited highest toxicity phytopathogen. Bacteria genus exhibit superior metabolite-producing capacity, with lipopeptides (LPs)...

Abstract A selective Oxone-induced oxidation of oleocanthal and oleacein, the two main secoiridoids olive oil, to their bis-oxidized products is described. This protocol based on a Baeyer-Villiger mechanism concentration Oxone in final solution. The bis-oxidation aldehydic compounds could be extended for synthesis various semisynthetic analogs. obtained acids exhibit strong antioxidant activity, being efficient free radical scavengers.

Chios mastic gum (CMG), the resin of Pistacia lentiscus var. Chia, is a product with great ethnopharmacological and economic significance. This study attempts to investigate, for first time, activity CMG, its fractions isolated compounds against specific enzymes, which play pivotal roles in degradation proteins contained skin connective tissue. Initially, crude CMG was subjected extraction, fractionation isolation through different chromatographic techniques obtain acidic neutral fraction...

Neurotoxicity belongs to the leading factors inducing neurodegeneration-related diseases, such as Alzheimer’s (AD) and Parkinson’s disease. In particular, accumulation of β-amyloid proteins in brain, a hallmark AD, induces oxidative stress neurotoxicity. The use antioxidants AD is not sufficiently effective other pharmacological approaches tested failed cure, prevent or retard progression Clinical studies indicated that several medicinal plants display beneficial effects by improving memory...

Gentiopicroside (GPS) is a leading component of several plant species from Gentianaceae botanical family. As compound with plenty biological activities and that often consumed in dietary supplements herbal drugs, GPS has an important role the regulation physiological processes humans. Recent studies on type 2 receptors shed new light applications showing its agonistic properties could be meaningful future therapeutic strategies Parkinson’s disease, thyroid disorders or cancer states. This...

Gnetum montanum Markgr.(Gnetaceae) is used in Vietnamese traditional medicine for the treatment of rheumatoid, arthritis and bronchitis [1] while recently has been reported as an effective plant gout Vietnam [2]. Our study focused on isolation identification natural compounds from stems G. evaluation their inhibitory activity tyrosinase elastase enzymes.

Oleocanthal (OLEO), Oleacein (OLEA), Hydroxytyrosol (HT) and Oleuropein (OLEU) are high-value secondary metabolites of Olea europaea (Oleaceae) with numerous biological activities. Nevertheless, their absorption during the oral administration or skin applications is limited due to low bioavailability. The incorporation sensitive compounds in drug delivery nanosystems a well-established method overcome degradation bioavailability problems.

The genus Cymbidium Sw. is one of the most popular orchid commercialized either as loose flower or potted plant in floriculture worldwide. was provided by “Garoufalis“ greenhouses which produces annually more than 100,000 pots 80 different varieties. non- marketable parts are discarded (unsuitable flowers, leaves, pseudobulbs, roots), generating thus an enormous quantity unutilized biomass.The above by-products (extracts and pure compounds) were investigated for their dermo-cosmetic...

Gentiopicroside (GPC) is a high added value glycosylated secoiridoid with numerous biological activities including hepatoprotective, and anti-inflammatory activities. The aim of this study was the development an efficient method for recovery pure GPC from Gentiana lutea roots evaluation its anti-proliferative activity against cancer normal cell lines.

Oleanolic acid (OA) and maslinic acids (MA) represent the main triterpens of Olea europaea are characterized as high-value natural compounds with important biological activities. Due to increased scientific interest these compounds, large amounts pure metabolites urgently needed. In present study, a separation method based on Centrifugal Partition Extractor (CPE) was developed, resulting in rapid effective isolation oleanolic form. The preliminary study our group revealed that unpolar...

Olive oil is straightly correlated with the Mediterranean diet and providing health benefits. Most of beneficial characteristics EVOO are attributed to olive biophenols which compose Total Phenolic Fraction (TPF). In previous studies our group, solid support free liquid-liquid extraction chromatography techniques, were performed on laboratory scale for TPF further fractionation as well. Following this process, enriched fractions high importance molecules like oleocanthal, oleacein, MFLA,...

Fraxinus ornus (Oleaceae) bark contains a plethora of bioactive natural products and is used in traditional medicine for the treatment inflammation, arthritis, dysentery [1]. As few existing research works are old fragmented, there need to update scientific data, especially regarding phytochemistry bioactivity. Thus, goal this work was use synchronous analytical techniques in-depth analysis bark' chemical content, isolation its main secondary metabolites using "green" chromatography...

The most notable secoiridoids of Olive Oil, Oleocanthal and Oleacein gather intense scientific interest due to their potent biological activities [1]. Recently, 3-carboxylic forms, named Oleocanthalic Oleaceinic acids, have been isolated as minor components OO [2]. This fact has triggered the exploration various semisynthetic approaches for better understanding mechanism action well discovery new bioactive compounds. In this context, preparation was investigated suitable reaction conditions...

The issues that the plant protection sector is facing dictate need for discovery of improved sources bioactivity as products. Within this context, endophytes have become focus research based on their capacity to synthesize compounds with unique bioactivity.