A5013207713- Phytochemicals and Antioxidant Activities
- Advanced Drug Delivery Systems
- Antibiotic Resistance in Bacteria
- Tea Polyphenols and Effects
- Membrane Separation and Gas Transport
- Conducting polymers and applications
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Neutropenia and Cancer Infections
- Advanced Polymer Synthesis and Characterization
- Block Copolymer Self-Assembly
- Leprosy Research and Treatment
- Curcumin's Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Natural Antidiabetic Agents Studies
- Enzyme Catalysis and Immobilization
- Neuroscience and Neural Engineering
- Drug Solubulity and Delivery Systems
- Tannin, Tannase and Anticancer Activities
- Burkholderia infections and melioidosis
- Antibiotics Pharmacokinetics and Efficacy
National and Kapodistrian University of Athens
2022-2025
Ropinirole is a non-ergolinic dopamine agonist used to manage Parkinson's disease and it characterized by poor oral bioavailability. This study aimed design develop advanced drug delivery systems composed of poloxamer 407, non-ionic surfactant (Tween 80), cyclodextrins (methyl-β-CD or hydroxy-propyl-β-CD) for possible brain targeting ropinirole after nasal administration the treatment disease. The hybrid were formed thin-film hydration method, followed an extensive physicochemical...
Abstract Cyclodextrin (CD)-block copolymer hybrid systems have recently received great attention from the pharmaceutical and materials research community because this combination can result in new biomaterials supramolecular structures, which possess physicochemical thermotropic properties of both classes materials. Different structures CD-block been described ( i.e. , micelles, vehicles, core-shell nanospheres, membranes) they encapsulate active ingredients or other bioactive compounds. The...
Abstract Background Minocycline has made a comeback in the drug armamentarium as treatment option for infections due to Acinetobacter baumannii. Although, it been launched 1960s, scarce pharmacokinetic studies have published. This open-label, prospective clinical study was conducted critical ill patients with documented infections, mainly VAP-associated pneumonia, attributed extensively-drug or pan-drug resistant baumannii, susceptible-or intermediate susceptible minocycline strains, treated...
Abstract Objectives Multidrug-resistant Acinetobacter baumannii (MDR-A. baumannii) has become an emerging pathogen, causing ventilator-associated pneumonia (VAP), with limited treatment options available. MIN re-emerged as a potential option for MDR pathogens. However, evidence regarding pharmacokinetic properties in critically ill patients is scarce and primarily to IV administration. To address the knowledge gap regions where unavailable, prospective, open-label study was conducted...
Hybrid PEO- b -PCL/Tween 80/cyclodextrin systems: physicochemical and morphological characterization, in vitro release studies.