A5010592110- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
- Statistical Methods in Clinical Trials
- Pneumonia and Respiratory Infections
- Fractional Differential Equations Solutions
- Pharmaceutical studies and practices
- Advanced Control Systems Design
- Statistical Methods and Bayesian Inference
- Receptor Mechanisms and Signaling
- Analytical Methods in Pharmaceuticals
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Innovative Microfluidic and Catalytic Techniques Innovation
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Statistical Methods and Inference
- Protein purification and stability
- Computational Drug Discovery Methods
- Helminth infection and control
- Optimal Experimental Design Methods
- Pharmacogenetics and Drug Metabolism
- Inhalation and Respiratory Drug Delivery
- Lipid Membrane Structure and Behavior
National and Kapodistrian University of Athens
2016-2025
Athena Research and Innovation Center In Information Communication & Knowledge Technologies
2020-2024
Istituto per le Applicazioni del Calcolo Mauro Picone
2024
National Research Council
2024
Athens University of Economics and Business
2019
University of Manchester
2004-2009
Queen's University Belfast
2009
Weatherford College
2007
Objectives: Tacrolimus, a Biopharmaceutics Classification System (BCS) class II drug, is widely used for transplant patients to prevent graft rejection. To enhance its bioavailability, amorphous solid dispersion (ASD) formulations were developed and evaluated. The release properties of several ASD-based tacrolimus studied using an in-house USP IV dissolution method. Methods: pharmacokinetics promising test product compared with the commercially available Advagraf® in pilot clinical...
Abstract Objectives Multidrug-resistant Acinetobacter baumannii (MDR-A. baumannii) has become an emerging pathogen, causing ventilator-associated pneumonia (VAP), with limited treatment options available. MIN re-emerged as a potential option for MDR pathogens. However, evidence regarding pharmacokinetic properties in critically ill patients is scarce and primarily to IV administration. To address the knowledge gap regions where unavailable, prospective, open-label study was conducted...
An algorithm for automatic order reduction of models defined by large systems differential equations is presented. The was developed with biology in mind and the motivation behind it to develop mechanistic pharmacokinetic/pharmacodynamic from already available models. approach used model proper lumping system's states based on a search through possible combinations lumps. To avoid combinatorial explosion, heuristic, greedy strategy employed comparison full exhaustive provides evidence that...
Poor oral absorption is one of the most common reasons for a drug to be terminated during development. Oral complex process affected by many competing factors related compound, formulation and gastrointestinal physiology. Throughout development, in silico, computational mathematical models play important roles support development decision making absorption-related issues. These range from simple empirical rule thumb tools sophisticated dynamic systems. This article reviews different methods...
A webinar series that was organised by the Academy of Pharmaceutical Sciences Biopharmaceutics focus group in 2021 focused on challenges developing clinically relevant dissolution specifications (CRDSs) for oral drug products. Industrial scientists, together with regulatory and academic came through a six webinars, to discuss progress field, emerging trends, areas continued collaboration harmonisation. Each also hosted Q&A session where participants could shared topic information. Although...
Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization grid search estimate physiological pharmacological emergent properties by exploring deterministic methods that are more appropriate have potentially superior performance than...