A5020987375- Radiopharmaceutical Chemistry and Applications
- Distributed and Parallel Computing Systems
- Advanced Data Compression Techniques
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced Wireless Communication Techniques
- Mathematical Biology Tumor Growth
- Autoimmune Bullous Skin Diseases
- Orthopaedic implants and arthroplasty
- Statistical Methods and Inference
- Wireless Communication Networks Research
- Satellite Communication Systems
- Evolution and Genetic Dynamics
- Health Systems, Economic Evaluations, Quality of Life
- Infrared Thermography in Medicine
- Statistical Methods in Clinical Trials
- Algorithms and Data Compression
- Gene Regulatory Network Analysis
- Computational Physics and Python Applications
- Nonlinear Dynamics and Pattern Formation
- Cell Adhesion Molecules Research
- Historical and Linguistic Studies
- CAR-T cell therapy research
- Advanced Data Storage Technologies
- Immunodeficiency and Autoimmune Disorders
Harley-Davidson (United States)
2016-2019
Phoenixville Hospital
2017
GlaxoSmithKline (United States)
2013
Jensen Hughes (United States)
1993
This article represents the first in a series of tutorials on model evaluation nonlinear mixed effect models (NLMEMs), from International Society Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for NLMEM, with particular emphasis visual assessment. basic tutorial focuses presenting graphical NLMEM continuous data. It illustrates graphs correct or misspecified models, discusses their pros and cons, recalls definition metrics used.
PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent target interaction to support selection of an optimal dose for future efficacy testing. In this immuno-PET study the anti–human epidermal growth factor receptor (HER3) mAb GSK2849330, we investigated biodistribution <sup>89</sup>Zr-labeled GSK2849330 evaluated engagement as a function antibody mass dose. <b>Methods:</b><sup>89</sup>Zr-GSK2849330 distribution was monitored in 6 patients HER3-positive...
Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization grid search estimate physiological pharmacological emergent properties by exploring deterministic methods that are more appropriate have potentially superior performance than...
Many scientists would like to be able view and analyze quick look astronomical data on hand held devices linked by wireless network the Internet. Scientific is often characterized high dynamic range together with abrupt, localized or extended changes of spatial temporal statistical properties. I compare effectiveness algorithms for efficient approximation scientific that support low bit-rate, near real-time low-delay communication heterogeneous multidimensional over existing planned networks.