A5086358877- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Infant Health and Development
- Gut microbiota and health
- COVID-19 diagnosis using AI
- Virus-based gene therapy research
- Intravenous Infusion Technology and Safety
- Herpesvirus Infections and Treatments
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Combustion and Detonation Processes
- Infection Control and Ventilation
- Probiotics and Fermented Foods
University of Parma
2023-2024
The aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plantarum [Lpb. plantarum], Lacticaseibacillus rhamnosus, or Lactobacillus acidophilus) be administered lung for containment pathogen growth in patients with infections.
One of the strategies proposed for neutralization SARS-CoV-2 has been to synthetize small proteins able act as a decoy towards virus spike protein, preventing it from entering host cells. In this work, incorporation one these proteins, LCB1, within spray-dried formulation inhalation was investigated. A design experiments approach applied investigate optimal condition manufacturing an inhalable powder. The lead formulation, containing 6% w/w LCB1 well trehalose and L-leucine excipients,...
The correct use of dry powder inhalers by the patients is essential to ensure effective treatment and management disease. purpose work was assess consequence inhaler misuse in terms emitted dose aerodynamic parameters. One reservoir multidose device (Foster-NEXThaler®) one pre-dosed (Relvar-Ellipta®), both sharing "open, inhale close" procedure, were subject study. NEXThaler activated at different degrees inclination showed a consistent delivery for drugs included formulation (beclometasone...
This work illustrates the development of a dry inhalation powder cyclosporine-A for prevention rejection after lung transplantation and treatment COVID-19. The influence excipients on spray-dried powder's critical quality attributes was explored. best-performing in terms dissolution time respirability obtained starting from concentration ethanol 45% (v/v) feedstock solution 20% (w/w) mannitol. showed faster profile (Weibull 59.5 min) than poorly soluble raw material (169.0 min). exhibited...