A5042334956- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Advancements in Semiconductor Devices and Circuit Design
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Infection Control and Ventilation
- Cardiac Fibrosis and Remodeling
- Glycosylation and Glycoproteins Research
- Cardiac electrophysiology and arrhythmias
- COVID-19 diagnosis using AI
- Atrial Fibrillation Management and Outcomes
University of Parma
2019-2020
One of the strategies proposed for neutralization SARS-CoV-2 has been to synthetize small proteins able act as a decoy towards virus spike protein, preventing it from entering host cells. In this work, incorporation one these proteins, LCB1, within spray-dried formulation inhalation was investigated. A design experiments approach applied investigate optimal condition manufacturing an inhalable powder. The lead formulation, containing 6% w/w LCB1 well trehalose and L-leucine excipients,...
Background: Scientific research on atrial fibrosis in fibrillation (AF) has mainly focused quantitative or molecular features. The purpose of this study was to perform a clinicoarchitectural/structural investigation provide one key understanding the electrophysiological/clinical aspects AF. Methods: We characterized (amount, architecture, cellular components, and ultrastructure) left biopsies from 121 patients with persistent/long-lasting persistent AF (group 1; 59 males; 60±11 years; 91...
The mutational drift of SARS-CoV-2 and the appearance multiple variants, including latest Omicron variant its sub-lineages, has significantly reduced (and in some cases abolished) protective efficacy Wuhan spike-antigen-based vaccines therapeutic antibodies. One most functionally constrained thus largely invariable regions spike protein is one involved interaction with ACE2 receptor mediating cellular entry SARS-CoV-2. Engineered ACE2, both as a full-length or an engineered polypeptide...