A5054520304- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Cardiovascular Disease and Adiposity
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Sesquiterpenes and Asteraceae Studies
- MicroRNA in disease regulation
- Contact Dermatitis and Allergies
- Environmental Chemistry and Analysis
- Plant biochemistry and biosynthesis
- Dermatology and Skin Diseases
- Essential Oils and Antimicrobial Activity
- Neonatal skin health care
- Ginkgo biloba and Cashew Applications
- Epilepsy research and treatment
- Restraint-Related Deaths
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Nerve injury and regeneration
- Chemical Thermodynamics and Molecular Structure
- Advanced Nanomaterials in Catalysis
- Plant Toxicity and Pharmacological Properties
- Analytical Methods in Pharmaceuticals
Universidade Federal do Rio Grande do Sul
2012-2021
In order to search for new approaches treat glioma, intranasal administration has been proposed as an alternative route deliver drugs into the brain. Among drug alternatives, kaempferol (KPF) reported induce glioma cell death. This study aimed prepare nanoemulsions containing KPF with and without chitosan investigate their potential brain delivery following administration, evaluate antitumor activity against cells. KPF-loaded nanoemulsion (KPF-NE) mucoadhesive (KPF-MNE) were prepared by...
Aim: To characterize a method to isolate glioma-derived extracellular vesicles (GEVs) and understand their role in immune system modulation glioma progression. Materials & methods: GEVs were isolated by differential centrifugation from C6 cell supernatant characterized size expression of CD9, HSP70, CD39 CD73. The model was performed injecting cells into the right striatum Wistar rats following groups: controls (C6 alone), coinjection + GEVs) intranasal administration followed cells, tumor...
Ischemic stroke is a major cause of death and disability, intensely demanding innovative accessible therapeutic strategies. Approaches presenting prolonged period for intervention new treatment administration routes are promising tools treatment. Here, we evaluated the potential neuroprotective properties nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After single...
The central nervous system shows limited regenerative capacity after injury. Spinal cord injury (SCI) is a devastating traumatic resulting in loss of sensory, motor, and autonomic function distal from the level An appropriate combination biomaterials bioactive substances currently thought to be promising approach treat this condition. Systemic administration valproic acid (VPA) has been previously shown promote functional recovery animal models SCI. In study, VPA was encapsulated...
Abstract Objective This study developed a novel child-friendly drug delivery system for pediatric HIV treatment: liquid, taste-masked, and solvent-free monoolein-based nanoparticles formulation containing indinavir (0.1%). Significance Adherence to antiretroviral therapy by patients is difficult because of the lack dosage forms adequate children. Methods Monoolein-based were developed. The particle size, zeta potential, pH, content, small angle X-ray scattering, stability, in vitro release...
ABSTRACT Ischemic stroke is a prominent cause of death and disability, demanding innovative therapeutic strategies. Accordingly, extracellular vesicles (EVs) released from mesenchymal stem cells are promising tools for treatment. In this study, we evaluated the potential neuroprotective properties EVs human adipose tissue (hAT-MSC), which were obtained healthy individual submitted to liposuction. A single intranasal administration was performed 24 h after ischemic in rats. The brain...
Abstract Ischemic stroke is a major cause of death and disability, demanding innovative accessible therapeutic strategies. Approaches presenting an optimal period for intervention new treatment administration routes are promising tools treatment. We evaluated the potential neuroprotective properties nasally administered human adipose tissue stem cells (hAT-MSCs)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. A single intranasal EV (200...
Abstract Ischemic stroke is a prominent cause of death and disability, demanding for innovative reachable therapeutic strategies. Thus, approaches presenting optimal period intervention new routes treatments administration as promising tools treatment. In this study, we evaluated the potential neuroprotective properties nasally human adipose tissue stem cells (hAT-MSC)-derived extracellular vesicles (EVs), obtained from healthy individuals submitted to liposuction. A single intranasal EVs...