A5045018063- Mesenchymal stem cell research
- Cardiovascular Disease and Adiposity
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
Hospital de Clínicas de Porto Alegre
2020-2021
Ischemic stroke is a major cause of death and disability, intensely demanding innovative accessible therapeutic strategies. Approaches presenting prolonged period for intervention new treatment administration routes are promising tools treatment. Here, we evaluated the potential neuroprotective properties nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After single...
To evaluate the use of adipose-derived stem cells (ADSC) in reducing necrosis area an experimental model cutaneous ischemic flap rats submitted to subcutaneous nicotine injection simulate a smoker patient.In study, 30 were enrolled and divided into two groups 15 animals all create flaps on their backs. Other 10 used only obtain adipose tissue derived (ADSC). The first group (n=15) received ADSC treatment at end surgery while other group, control (n=15), no interventions. After euthanasia,...
ABSTRACT Ischemic stroke is a prominent cause of death and disability, demanding innovative therapeutic strategies. Accordingly, extracellular vesicles (EVs) released from mesenchymal stem cells are promising tools for treatment. In this study, we evaluated the potential neuroprotective properties EVs human adipose tissue (hAT-MSC), which were obtained healthy individual submitted to liposuction. A single intranasal administration was performed 24 h after ischemic in rats. The brain...
Abstract Ischemic stroke is a major cause of death and disability, demanding innovative accessible therapeutic strategies. Approaches presenting an optimal period for intervention new treatment administration routes are promising tools treatment. We evaluated the potential neuroprotective properties nasally administered human adipose tissue stem cells (hAT-MSCs)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. A single intranasal EV (200...
Abstract Ischemic stroke is a prominent cause of death and disability, demanding for innovative reachable therapeutic strategies. Thus, approaches presenting optimal period intervention new routes treatments administration as promising tools treatment. In this study, we evaluated the potential neuroprotective properties nasally human adipose tissue stem cells (hAT-MSC)-derived extracellular vesicles (EVs), obtained from healthy individuals submitted to liposuction. A single intranasal EVs...