A5061254473- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Sphingolipid Metabolism and Signaling
- Lysosomal Storage Disorders Research
- Sperm and Testicular Function
- Genetics, Aging, and Longevity in Model Organisms
- Organ Transplantation Techniques and Outcomes
- Folate and B Vitamins Research
- Cholesterol and Lipid Metabolism
- Bipolar Disorder and Treatment
- Pancreatic function and diabetes
- Caveolin-1 and cellular processes
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Air Quality and Health Impacts
Universidade Federal do Rio Grande do Sul
2016-2025
Pontifícia Universidade Católica do Rio Grande do Sul
2021
University of British Columbia
2017
Hospital de Clínicas de Porto Alegre
2017
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2017
Universidade Federal do Rio Grande
2013-2015
Universidade Federal de Ciências da Saúde de Porto Alegre
2007-2012
Universidade Federal de Santa Catarina
2008
The purpose of this study was to evaluate the bioactive compounds and antioxidant activity extracts from araçá (Psidium cattleianum), butiá (Butia eriospatha), pitanga (Eugenia uniflora) fruits with different flesh colors (i.e., purple, red, orange), blackberries (Rubus sp.; cv. Xavante Cherokee) collected in southern region Brazil. content ascorbic acid, total carotenoids, phenolics were determined. profile phenolic assessed by high-performance liquid chromatography combined diode array...
Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim this study was to examine potential differences brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with disorder, their siblings, healthy controls. Thirty-six disorder type I, 39 44 controls were assessed. Serum levels interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11,...
Abstract Growing evidence defines macrophages (Mφ) as plastic cells with wide-ranging states of activation and expression different markers that are time location dependent. Distinct from the simple M1/M2 dichotomy initially proposed, extensive diversity macrophage phenotypes have been extensively demonstrated characteristic features monocyte-macrophage differentiation, highlighting difficulty defining complex profiles by a limited number genes. Since description is currently contentious...
Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have disorders, including oxidative stress, inflammation, telomere shortening. The objective this study was to compare length among participants BD at early late stages age- gender-matched healthy controls.Twenty-six euthymic subjects 34 controls were recruited. Genomic DNA extracted from...
Alzheimer's disease is a neurodegenerative disorder characterized by extracellular deposition of amyloid‐β (Aβ) peptide and hyperphosphorylation Tau protein, which ultimately leads to the formation intracellular neurofibrillary tangles cell death. Increasing evidence indicates that genistein, soy isoflavone, has neuroprotective effects against Aβ‐induced toxicity. However, molecular mechanisms involved in its neuroprotection are not well understood. In this study, we have established...
Introduction Eotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 involved in aging process, as it upregulated elderly, and correlated with shorter telomere length leukocytes from children. Despite its potential pro-aging effects, precise contribution underlying mechanisms promotion cellular senescence remains unclear. Therefore, primary goal this study was explore role on development signaling...
Congenital hypothyroidism was induced in rats by adding 0.05% 6-propyl-2-thiouracil the drinking water from day 9 of gestation, and continually up to postnatal 15. Structural alterations observed light microscopy seminiferous tubules transmission electron Sertoli cells treated animals were consistent with hypothyroid condition. Hypothyroidism also associated high phospho-p38 mitogen-activated protein kinase decreased phospho-extracellular signal-regulated 1/2 levels. Furthermore,...
ABSTRACT Purpose Premature cellular senescence is a pivotal process in aging and age‐related diseases, triggered by various stressors. However, this not homogeneous phenotype, but heterogeneous state composed of multiple programs with different compositions. Therefore, understanding the complex dynamics requires systemic approach. We introduce PseudoCell, multivalued logical regulatory network designed to explore molecular intricacies premature senescence. Methods PseudoCell integrates key...
Skeletal muscle disuse results in myofibrillar atrophy and protein degradation, via inflammatory oxidative stress-mediated NF-kB signaling pathway activation. Nutritional interventions, such as l-glutamine (GLN) supplementation have shown antioxidant properties cytoprotective effects through the modulation on 70-kDa heat shock (HSP70) expression. However, these GLN-mediated cell pathways biochemical mechanisms that control content degradation situations are poorly known yet. This study...
Adipose-derived stem cells (ADSC) are multipotent implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, progressive accumulation of senescent compromised ADSC function. In this study, we aimed to explore mechanisms the environment present obesity modulating phenotype. We evaluated phenotypic functional alterations through 18 days treatment. were cultivated conditioned medium supplemented pool...
Ischemic stroke is a major cause of death and disability, intensely demanding innovative accessible therapeutic strategies. Approaches presenting prolonged period for intervention new treatment administration routes are promising tools treatment. Here, we evaluated the potential neuroprotective properties nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After single...
BACKGROUND Prostate cancer is a leading cause of death among men due to the limited number treatment strategies available for advanced disease. γ‐oryzanol component rice bran, rich in phytosterols, known its antioxidant, anti‐carcinogenic and endocrinological effects. It that may affect prostate cells through down regulation antioxidant genes phytosterols have anti‐proliferative apoptotic There are evidences showing some components can modulate involved development progression cancer, as...
Objective To evaluate the consequences of plasma from individuals with obesity on parameters associated immunosenescence in unrelated healthy peripheral blood mononuclear cells (PBMC). Methods Freshly isolated PBMC were incubated media supplemented 10% or control subjects for first 4 hours 24 to 120 culture. Results Plasma modulated phenotype PBMC, leading a higher rate apoptosis, lower amounts phospho‐γH2AX and ‐p53, mitochondrial dysfunction. After hours, there was secretion inflammatory...
Abstract Evidence on the relationship between genetics and mental health are flourishing. However, few studies evaluating early biomarkers that might link genes, environment, psychopathology. We aimed to study telomere length (TL) epigenetic age acceleration (AA) in a cohort of adolescents with without anxiety disorders (N = 234). evaluated representative subsample participants at baseline after 5 years (n 76) categorized them according their disorder diagnosis both time points: (1) control...