A5000143494- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Inhalation and Respiratory Drug Delivery
- Telomeres, Telomerase, and Senescence
- Transplantation: Methods and Outcomes
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Breastfeeding Practices and Influences
- Infant Development and Preterm Care
- Infant Health and Development
- Injury Epidemiology and Prevention
- Genetics, Aging, and Longevity in Model Organisms
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Allergic Rhinitis and Sensitization
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2025
Regeneron (United States)
2021-2024
BC Cancer Agency
2024
University of Maryland, Baltimore
2023
Hospital Moinhos de Vento
2022
Universidade Federal do Rio Grande do Sul
2003-2020
Centro de Referência em Informação Ambiental
2020
American Thoracic Society
2007-2018
Montreal Children's Hospital
2018
Hospital São Lucas da PUCRS
2017
How genes affect human obesity Obesity is linked to many diseases, including diabetes, cancer, and heart disease. There thus great interest in understanding how predispose individuals to, or protect from, obesity. Akbari et al. sequenced more than 600,000 exomes from the United Kingdom, States, Mexico identified 16 rare coding variants (see Perspective by Yeo O'Rahilly). Some of alleles associated with body mass index (BMI) were brain-expressed G protein–coupled receptors. One variant allele...
Forced expiratory flows (FEF) can be measured in infants from lung volumes initiated near total capacity. In order to establish reference values and evaluate growth, we obtained measurements 155 healthy subjects between 3 149 wk of age. vital capacity (FVC) was highly correlated with body length; however, after accounting for length, age also significant. When were divided at the median (40 wk) younger compared older had a significantly larger slope length (3.7 versus 2.8; p = 0.002). The...
Advances in spirometry measurement techniques have made it possible to obtain measurements children as young 3 years of age; however, practice, application remains limited by the lack appropriate reference data for children, which are often based on population-specific samples.We aimed build previous models collating existing (aged 3-7 yr), produce updated prediction equations that span preschool and also linked established older adults.The Asthma UK Collaborative Initiative was collate lung...
To present official longitudinal data on the impact of asthma in Brazil between 2008 and 2013.This was a descriptive study collected 2013 from an Brazilian national database, including asthma-related number hospitalizations, mortality, hospitalization costs. A geographical subanalysis also performed.In 2013, 2,047 people died (5 deaths/day), with more than 120,000 hospitalizations. During whole period, absolute deaths hospitalizations decreased by 10% 36%, respectively. However, in-hospital...
Interventions to tackle the coronavirus disease 2019 (COVID-19) pandemic may affect burden of other respiratory diseases. Considering repercussions these unique social experiences infant health, this study aims assess early impact distancing due COVID-19 in hospital admissions for acute bronchiolitis.Data from hospitalizations bronchiolitis infants <1 year age were obtained Department Informatics Brazilian Public Health database period between 2016 and 2020. These data also analyzed by...
It remains unclear whether premature birth, in the absence of neonatal respiratory disease, results abnormal growth and development lung. We previously reported that a group healthy infants born at 32-34 weeks' gestation without complications had decreased forced expiratory flows normal vital capacities 2 months age.Our current study evaluated these prematurely exhibited improvement or "catch-up" their lung function during second year life.Longitudinal measurements by raised volume rapid...
Asthma is common in urban centres Latin America, but atopic asthma may not be the main phenotype among children. Helminth infections are highly prevalent poor populations, and it was hypothesised that they attenuate allergic asthma, whereas other factors related to expression of a nonatopic wheeze/asthma phenotype. A total 1,982 children from Southern Brazil with mean+/-sd age 10.1+/-0.76 yrs completed questionnaires, 1,011 were evaluated for intestinal parasites atopy using skin-prick tests...
Abstract Background Lower respiratory tract infection (LRTI) is a major cause of pediatric morbidity and mortality, especially among non-affluent communities. In this study we determine the impact viruses how viral co-detections/infections can affect clinical LRTI severity in children hospital setting. Methods Patients younger than 3 years age admitted to tertiary Brazil during months high prevalence had samples collected from nasopharyngeal aspiration. These were tested for 13 different...
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Preterm delivery has been associated with a higher incidence of respiratory morbidity even in infants that do not have significant disease during the neonatal period. Reduced flows reported children and adolescents born prematurely.The aim this study was to assess lung function healthy preterm first months life.Preterm less than 48 h supplemental oxygen were recruited. Lung assessed by raised-volume rapid thoracic compression life. The control group consisted full-term without history...
Abstract Murine mAb to CD13, CD14, and class II MHC, are able mobilize calcium in normal human monocytes enhance superoxide production primed cells. Antibodies CD35 (CR1) also cause a minor response some individuals. CD11a, CD11b, CD11c, CD15, CD17, CD18, CD45 do not activate monocytes. The ability of monocyte activation is only dependent on the Ag with which they react but isotype antibodies individual from whom were obtained. It shown that this because so by formation Ag-antibody-FcR...
Measuring interrupter resistance ( R int ) is an increasingly popular lung function technique and especially suitable for preschool children because it simple, quick requires only passive cooperation. A European Respiratory Society (ERS)/American Thoracic (ATS) Task Force recently published empirical recommendations related to procedures, limitations interpretation of the technique. However, valid interpretation, high-quality reference equations are required these have been lacking. The aim...
Objective To evaluate whether a 30‐minute decision‐to‐delivery interval is realistic target for emergency caesarean section. Design An audit of all sections over five separate periods. Setting A district general hospital. Participants Five groups women (343 women) with an indication Methods Following initial survey, structured time sheet was introduced, followed by four other surveys to complete the cycle. Main outcome measure The proportion where measures achieved within 30 minutes. reasons...
The present study is aimed to describe the changes in prevalence of symptoms asthma, rhinitis and eczema among Brazilian adolescents (AD, 13–14 years old) between Phases 1 3 International Study Asthma Allergies Childhood (ISAAC). self-reported AD from five cities (Curitiba, Porto Alegre, Recife, Salvador São Paulo), obtained during ISAAC Phase (n = 15 419) 684), was compared determine trend a 7-year interval. There reduction current wheezing increasing nocturnal cough when averaging figures...