A5045264184- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Education during COVID-19 pandemic
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Virology and Viral Diseases
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Regulation
- Neonatal Respiratory Health Research
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Tracheal and airway disorders
- Celiac Disease Research and Management
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
Hospital Moinhos de Vento
2020-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2015-2024
Universidade Federal de Ciências da Saúde de Porto Alegre
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2017
National Institutes of Health
2017
Instituto do Cérebro
2016
Infant Foundation
2014
Universidade Federal do Rio Grande do Sul
2013
Clinics Hospital of Ribeirão Preto
2008
Universidade de São Paulo
2008
Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing spread could impact transmission other respiratory viruses as well. The aim this study is to report detection RSV during period distancing due COVID-19 pandemic in a heavily affected community.Prospective with pediatric adult populations seeking care for COVID-19-like...
Interventions to tackle the coronavirus disease 2019 (COVID-19) pandemic may affect burden of other respiratory diseases. Considering repercussions these unique social experiences infant health, this study aims assess early impact distancing due COVID-19 in hospital admissions for acute bronchiolitis.Data from hospitalizations bronchiolitis infants <1 year age were obtained Department Informatics Brazilian Public Health database period between 2016 and 2020. These data also analyzed by...
Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infants under 2 years old. Necroptosis has been implicated outcomes respiratory infections. We report that RSV infection triggers necroptosis primary mouse macrophages and human monocytes a RIPK1-, RIPK3- MLKL-dependent manner. Moreover, pathways are harmful to clearance from alveolar macrophages. Additionally, Ripk3 −/− mice were protected RSV-induced weight loss presented with reduced viral loads lungs. Alveolar...
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess difference cellular or humoral immune responses of pediatric and adult patients to see if these factors contribute severity dichotomy. Children's non-specific profile is dominated by naive lymphocytes HLA-DR
Changes in the epidemiology of respiratory infections during restrictions imposed as a response to coronavirus disease 2019 (COVID-19) pandemic have been reported elsewhere. The present study's aim was describe prevalence large array pathogens symptomatic children and adolescents Southern Brazil.Hospitalized outpatients aged 2 months 18 years with signs symptoms acute COVID-19 were prospectively enrolled study from May November 2020 two hospitals metropolitan area Brazilian city. All...
Respiratory syncytial virus is a major cause of lower respiratory tract infection morbidity and mortality in children globally, causing 3·2–3·6 million hospitalisations more than 100 000 deaths annually younger 5 years, 99% which occur low-income middle-income countries (LMICs).1Li Y Wang X Blau DM et al.Global, regional, national disease burden estimates acute infections due to years 2019: systematic analysis.Lancet. 2022; 399: 2047-2064Summary Full Text PDF PubMed Scopus (187) Google...
This study aimed to critically review the literature available regarding Zika virus (ZikaV) outbreak in Brazil and its possible association with microcephaly cases. Experts from Instituto do Cérebro Rio Grande Sul performed a critical (nonsystematic) different aspects of ZikaV Brazil, such as transmission, epidemiology, diagnostic criteria, increase reports. The PubMed search using key word February 2016 yielded 151 articles. manuscripts were reviewed, well all publications/guidelines...
This study aims to describe the clinical characteristics and predictors of mechanical ventilation adult inpatients with COVID-19 in a single center.A retrospective cohort was performed included hospitalized from March 17th May 3rd, 2020, who were diagnosed SARS-CoV-2 infection. Clinical demographic extracted electronic medical records.Overall, 88 consecutive patients this study. The median age 63 years (IQR 49 - 71); 59 (67%) male, 65 (86%) had college degree 67 (76%) at least one...
The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs low- and middle-income countries (LMICs). PROUD (Preventing RespiratOry virUs unDerdeveloped countries) Taskforce 24 RSV worldwide experts assessed key needs for prevention LMICs, including vaccine newer preventive measures.A global, survey-based study was undertaken 2021. An online questionnaire developed following three meetings the panellists wherein factors related to infection, its...
The knowledge about the impact of nonpharmacological measures to control COVID-19 pandemic can give insight into ways in which they also be applied for other respiratory diseases. To assess containment on pneumonia hospitalizations children from 0 14 years age Brazil.Data hospital admissions were obtained Department Informatics Brazilian Public Health System database period 2015-2020 and analyzed by macroregions groups. evaluate effect measures, incidence pneumonia, absolute reduction...
Introduction Pertussis is an important public health problem worldwide, especially in infants. An increase the incidence many countries occurred after 2010, including Brazil. In 2013, dTpa vaccine was introduced Brazil national immunization schedule of pregnant women. The objective this study to evaluate trends pertussis children under 1 year old, and impact introduction during pregnancy. Methods hospitalizations non-hospitalized confirmed cases neonates (< month age) young infants (1...
Respiratory syncytial virus (RSV)-specific CD8(+) T cell responses do not protect against reinfection. Activation of mammalian target rapamycin (mTOR) impairs memory differentiation. Our hypothesis was that RSV inhibits the formation cells through mTOR activation. To explore this, human and mouse were used. induced phosphorylation at Ser2448 in CD8 cells. activation by completely inhibited using rapamycin. RSV-infected children presented higher gene expression on nasal washes comparing to...
The viral dynamics and the role of children in spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values among with confirmed SARS-CoV-2 compared that adult subjects.Patients (from months ≤18 years age adults) signs symptoms infection for less than 7 days were prospectively enrolled study from May November 2020. All participants performed...
Background: Perinatally HIV-infected (PHIV) children are at risk for under-vaccination and poor vaccine response 4 years of age. Childhood coverage immune were compared between PHIV HIV-exposed uninfected (HEU) in Latin America the Caribbean. Methods: HEU enrolled prospectively 15 sites from 2002 to 2009. Full vaccination by age was defined as: 3 hepatitis B virus doses; tetanus toxoid–containing doses Haemophilus influenzae type b 12 months or ≥1 dose given after months; one...
Background Persistent symptoms and exercise intolerance have been reported after COVID-19, even months the acute disease. Although, long-term impact on capacity health-related quality of life (HRQoL) is still unclear. Research question To assess functional HRQoL in patients hospitalized due to COVID-19. Study design methods This a prospective cohort study, conducted at two centers Brazil, that included post-discharge COVID-19 paired controls. The was by age, sex, body mass index...
The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence children young adults. In post-pandemic period, there was an increase cases during winter months 2011 2012 similar to seasonal virus. Since infections due are still occurring, present study aimed investigate risk factors for worse outcome children. A retrospective cohort performed reviewing charts hospitalized patients younger than 14 years reverse...
Objective To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during 3-month therapy period, observation for a further 3 months after treatment. Methods A randomized, double-blind, placebo-controlled trial was conducted 54 (6 to 5 years old) no past history recurrent attending daycare center. Family members were instructed administer one capsule per day 10 consecutive days, [...]
In 2020, a unique social experience was provided by the pandemic of coronavirus disease 2019 (COVID-19), caused severe acute respiratory syndrome 2. Interventions to tackle may affect burden other diseases.This study aims assess impact COVID-19 mitigation strategies on hospitalizations for asthma in children aged between 1 and 14 years, adults 20 59 elderly older than 60 years.Data from hospital admissions were obtained Department Informatics Brazilian Public Health System database period...