A5019916762- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Viral gastroenteritis research and epidemiology
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Infant Health and Development
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2022
Infant Foundation
2016
Gut microbiota-derived short-chain fatty-acid (SFCA) acetate protects mice against RSV A2 strain infection by increasing interferon-β production and expression of interferon-stimulated genes (ISGs). However, the role SFCA in using strains isolated from patients is unknown.We first used clinical infants hospitalized with bronchiolitis to investigate effects vitro SCFA-acetate treatment human pulmonary epithelial cells. We next examined whether beneficial a mouse model isolates. sought...
ABSTRACT Objective: To investigate the correlation between respiratory syncytial viral load and length of hospitalization in infants with acute wheezing episodes. Methods: This was a two-year, cross-sectional study ≤ 12 months age bronchiolitis at time admission to tertiary hospital. For identification viruses, nasopharyngeal secretions were collected. Samples analyzed (throughout period) by direct immunofluorescence (in second year study) quantitative real-time PCR. We screened for three...
The aim of this study was to evaluate the association between possible functional interleukin-10 (IL-10) polymorphisms, IL-10 expression and regulatory T cells (Tregs) frequency, and/or asthma severity in a sample children adolescents.This is nested case-control genetic study. consisted adolescents aged 8-14 from public schools. Four polymorphisms gene (rs1518111, rs3024490, rs3024496, rs3024491) were genotyped asthmatic subjects controls using real-time PCR. Tregs analyzed peripheral blood...
Objective: A significant proportion of the infants developed recurrent wheezing after an acute bronchiolitis (AB) event. Recent studies have demonstrated protection for wheeze and lower respiratory morbidity in treated with azithromycin during wheezing. The aim present study was to test hypothesis that administration AB event reduces subsequent hospital re-admissions. Methods: This is a secondary analysis randomized, double-blinded, placebo-controlled trial, including unpublished data...
Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response viral infections is possibly influenced by genetic polymorphisms linked the regulation inflammatory response. In present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) variants are associated with severity AB. A group Brazilian infants hospitalized AB a control (infants no or mild AB, without hospitalization) were genotyped for four...
Objective To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during 3-month therapy period, observation for a further 3 months after treatment. Methods A randomized, double-blind, placebo-controlled trial was conducted 54 (6 to 5 years old) no past history recurrent attending daycare center. Family members were instructed administer one capsule per day 10 consecutive days, [...]
Abstract Respiratory syncytial virus (RSV) is a common cause of childhood lower respiratory tract infections. The recent failure vaccine candidate based on recombinant F protein underlines the urgent need to better understand protective human memory immune response against RSV. Signal transducer and activator transcription 3 (STAT3) factor that promotes maturation CD8 T cell in cooperation with IL-10 IL-21. However, role STAT3 during RSV infection remains be elucidated. We found infants...
Background: Gut microbiota-derived short-chain fatty-acid (SFCA) acetate protects mice againstRSV A2 strain infection by increasing interferon-β production and expression of interferonstimulated genes (ISGs). However, the role SFCAs in RSV using strains isolated from patients is unknown.Methods: We first used clinical infants hospitalized with bronchiolitis to investigate effects vitro treatment human pulmonary epithelial cells. next examined whether beneficial a mouse model isolates. sought...