A5039923199- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Impact on Reproduction
- Neuropeptides and Animal Physiology
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Peptidase Inhibition and Analysis
- Viral gastroenteritis research and epidemiology
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Virus-based gene therapy research
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- Vagus Nerve Stimulation Research
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Inhalation and Respiratory Drug Delivery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Birth, Development, and Health
- Ion Channels and Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
Tulane University
2019-2024
Pediatrics and Genetics
1999-2023
Cleveland Clinic
2013-2020
Cleveland Clinic Lerner College of Medicine
2019
Foundation Center
2018
Boston Children's Hospital
2014-2015
West Virginia University
2005-2012
Children’s Institute
2002-2007
University of Miami
1996-2007
National Research Council
2005
The respiratory system is constantly exposed to viral infections that are responsible for mild severe diseases. In this narrative review, we focalized the attention on syncytial virus (RSV), influenza virus, and acute syndrome-coronavirus-2 (SARS-CoV-2) infections, high morbidity mortality in last decades. We reviewed human innate adaptive immune responses airways following infection, focusing a particular population: newborns pregnant women. recent Coronavirus disease-2019 (COVID-19)...
SUMMARY Our aim was to obtain knowledge of how meteorological conditions affect community epidemics respiratory syncytial virus (RSV) infection. To this end we recorded year-round RSV activity in nine cities that differ markedly geographic location and climate. We correlated local weather with weekly or monthly cases. reviewed similar reports from other areas varying Weekly related temperature a bimodal fashion, peaks at temperatures above 24–30°C 2–6°C. also greatest 45–65% relative...
Childhood asthma and obesity have reached epidemic proportions worldwide, the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. Yet, relationship between asthma, obesity, abnormal lipid glucose metabolism not well understood, nor has it been adequately explored in children.
After reading this article, readers should be able to:Human respiratory syncytial virus (RSV) is a single-stranded RNA of the Paramyxoviridae family whose genome includes 10 genes that encode 11 proteins (Figure 1). Two surface proteins, F (fusion) protein and G (attachment glycoprotein) protein, are major viral antigens play critical role in virulence RSV. The mediates RSV attachment to host cell, after which enables fusion plasma membranes permit passage into cell. also promotes...
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation are observed in COVID-19 patients.While the initial SARS-CoV-2 infection mainly infects lung epithelial cells, whether it also endothelial cells (ECs) to what extent SARS-CoV-2-mediated pulmonary endotheliitis is associated with remain be determined.Methods: To address these questions, we studied SARS-CoV-2-infected K18-hACE2 (K18) mice, a severe mouse model, as well samples from nonhuman primates...
Nerve growth factor (NGF) controls sensorineural development and responsiveness modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating substance P receptor, neurokinin 1 (NK ). We investigated whether expression NGF its trkA p75 receptors lungs is age dependent, it upregulated during RSV infection, affects neurogenic inflammation. Pathogen-free rats were killed at 2 (weanling) to 12...
Early-life infection by respiratory syncytial virus (RSV) is associated with aberrant expression of the prototypical neurotrophin nerve growth factor (NGF) and its cognate receptors in human bronchial epithelium. However, chain events leading to this outcome, functional implications for progression viral infection, has not been elucidated. This study sought test hypothesis that RSV modulates neurotrophic pathways airways silencing specific microRNAs (miRNAs), effect favors interfering...
Respiratory syncytial virus is a major cause of lower respiratory tract infection morbidity and mortality in children globally, causing 3·2–3·6 million hospitalisations more than 100 000 deaths annually younger 5 years, 99% which occur low-income middle-income countries (LMICs).1Li Y Wang X Blau DM et al.Global, regional, national disease burden estimates acute infections due to years 2019: systematic analysis.Lancet. 2022; 399: 2047-2064Summary Full Text PDF PubMed Scopus (187) Google...
Nerve growth factor and its receptors are upregulated in the lungs of weanling rats with lower respiratory tract infection caused by syncytial virus (RSV), this is a major mechanism inflammatory response against virus. However, no information available humans.We sought to determine whether expression neurotrophic factors increased human infants infected RSV.We used highly sensitive immunoassay measure concentrations nerve brain-derived proteins serum samples supernatants cell fractions...
Respiratory syncytial virus (RSV) is a major respiratory pathogen in infants. The first goal of this study was to determine whether the infection following endotracheal inoculation RSV Fischer 344 rats results increased inflammatory responses substance P (SP) either released by capsaicin from sensory nerves or injected into circulation. Five days after inoculation, extravasation Evans blue-labeled albumin SP significantly greater RSV-infected airways than pathogen-free controls....
Respiratory syncytial virus (RSV) is a major cause of hospitalization for infants and young children worldwide. RSV known to infect epithelial cells increase the permeability model airway monolayers in vitro. We hypothesized that infection also induces barrier dysfunction vivo. C57BL/6 mice were intranasally inoculated with RSV, on day 4 post-inoculation examined viral replication, lung inflammation, integrity as well structure molecular composition junctions. In parallel, primary mouse...
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Capsaicin increases the permeability of blood vessels in rat tracheal mucosa through a mechanism involving release tachykinins from sensory nerves. This capsaicin-induced increase vascular is potentiated by viral infections respiratory tract. The present study was done to determine whether this "neurogenic plasma extravasation" can be inhibited glucocorticoids, learn time course inhibition, and glucocorticoids prevent potentiating effect on neurogenic extravasation. Groups pathogen-free F344...