A5033317629- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Family and Patient Care in Intensive Care Units
- Vasculitis and related conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emergency and Acute Care Studies
- Viral gastroenteritis research and epidemiology
- Infant Development and Preterm Care
- Influenza Virus Research Studies
- Neuroscience of respiration and sleep
- Neonatal Health and Biochemistry
- Streptococcal Infections and Treatments
- Asthma and respiratory diseases
- Child Nutrition and Water Access
- Bacterial Infections and Vaccines
- Thyroid Cancer Diagnosis and Treatment
- Geological and Tectonic Studies in Latin America
- Mechanical Circulatory Support Devices
- Reproductive tract infections research
- Viral Infections and Vectors
- Child and Adolescent Health
Hospital General Universitario Gregorio Marañón
2015-2024
Centro de Investigación Biomédica en Red
2017-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
Hospital Clínico San Carlos
2024
Spanish National Centre for Cardiovascular Research
2024
Universidad Complutense de Madrid
2024
The University of Adelaide
2024
CSIRO Health and Biosecurity
2023
University of Havana
2023
Complejo Hospitalario de Ourense
2022
Data on how respiratory syncytial virus (RSV) genotypes influence disease severity and host immune responses is limited. Here, we characterized the genetic variability of RSV during 5 seasons, evaluated role subtypes, genotypes, viral loads in transcriptional profiles.
Worldwide G-glycoprotein phylogeny of human respiratory syncytial virus (hRSV) group A sequences revealed diversification in major clades and genotypes over more than 50 years recorded history. Multiple cocirculated during prolonged periods time, but recent dominance the GA2 genotype was noticed several studies, it is highlighted here with from viruses circulating recently Spain Panama. Reactivity monoclonal antibodies (MAbs) that recognize strain-variable epitopes G glycoprotein failed to...
Respiratory syncytial virus is a major cause of lower respiratory tract infection morbidity and mortality in children globally, causing 3·2–3·6 million hospitalisations more than 100 000 deaths annually younger 5 years, 99% which occur low-income middle-income countries (LMICs).1Li Y Wang X Blau DM et al.Global, regional, national disease burden estimates acute infections due to years 2019: systematic analysis.Lancet. 2022; 399: 2047-2064Summary Full Text PDF PubMed Scopus (187) Google...
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children under one year age. In high-income countries, RSV a significant overload care every winter, imposing burden to healthcare system, which has made development prevention strategies major global health priority. this context, new bivalent prefusion F protein-based vaccine (RSVpreF) recently been approved. The objective study was evaluate cost-effectiveness vaccinating pregnant women...
The diagnosis of iron deficiency anemia in malaria endemic areas is complicated by the influence infection on laboratory tests conventionally used to assess status. Determination soluble transferrin receptor (sTfR) levels has been shown be a sensitive indicator adults and not affected range infectious inflammatory conditions. utility sTfR remains unresolved. Three hundred fourteen infants rural area southern Tanzania living under conditions intense perennial transmission were studied...
To evaluate whether changes in concentrations of soluble (s) E-selectin, sP-selectin, sL-selectin, intercellular adhesion molecule 1 (sICAM-1), and vascular cell (sVCAM-1) reflect disease activity patients with ANCA-associated vasculitis serum levels these molecules are related to the degree renal failure chronic (CRF).A sandwich ELISA was used measure (i) sera from 20 antineutrophil cytoplasmic antibody (ANCA)-associated (10 Wegener's granulomatosis (WG) 10 microscopic polyangiitis (MPA)),...
BackgroundRespiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis. Precise and updated information about demographic characteristics, clinical manifestations, risk factors for severe disease are needed optimal implementation upcoming new therapeutic preventive interventions.ObjectivesThe main goals this study were to define epidemiology acute bronchiolitis in hospitalized young children during 5 calendar years Spain; evaluate differences manifestations between with RSV...
We analyzed the frequency, clinical impact and severity of respiratory syncytial virus (RSV) SARS-CoV-2 coinfections in a single pediatric center between March 2020 January 2023. Compared to RSV infections, RSV/SARS-CoV-2 were uncommon (2.1%), occurred more frequently during circulation omicron, associated with increased disease as defined by longer hospitalization need for high-flow nasal cannula.
We characterised the distress that parents experienced when their child was hospitalised for respiratory syncytial virus (RSV) infection.This survey-based, observational study conducted during 2014-2015. Meetings were held in Spain and Italy, with 24 of RSV infants 11 healthcare professionals RSV, which identified 110 factors related to parental distress. The resulting questionnaire completed by another 105 Spanish Italian 56 professionals, assess impact these had on distress, using a scale...
Bronchiolitis associated with the respiratory syncytial virus (RSV) is leading cause of hospitalization among infants aged < 1 year. The main objective this work was to assess nasal and fecal microbiota immune profiles in RSV bronchiolitis, compare them those healthy infants. For purpose, a total 58 RSV-positive bronchiolitis 17 (aged 18 months) were recruited case-control study, which approved by Ethics Committee Hospital Gregorio Marañón. Nasal samples obtained submitted bacterial...
To evaluate non-rapid eye movement (NREM) sleep instability, as measured by the cyclic alternating pattern (CAP), in first months of life a group normal healthy infants, order to obtain more information on maturation arousal mechanisms during NREM and set normative data CAP parameters this age range (from 1 4 life).Retrospective study.Sleep unit an academic centre.Twenty-three newborns infants with mean conceptional (gestational plus postnatal age) 47.6 + 3.8 weeks, 42 55 10 boys (43.47%),...
Potentially painful invasive procedures are often performed for diagnostic or therapeutic purposes in hospitalised paediatric patients. Approaches, such as virtual reality (VR), should be sought order to minimise pain and anxiety during these procedures.Hospitalised patients between 4 15-years-old requiring an procedure were included. Pain evaluation scales given children, relatives health workers. A comparison was made with whom VR used (with without concomitant use of a prilocaine/...