A5063039108- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- COVID-19 diagnosis using AI
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Education during COVID-19 pandemic
- Viral Infections and Outbreaks Research
Hospital Moinhos de Vento
2021-2023
Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing spread could impact transmission other respiratory viruses as well. The aim this study is to report detection RSV during period distancing due COVID-19 pandemic in a heavily affected community.Prospective with pediatric adult populations seeking care for COVID-19-like...
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess difference cellular or humoral immune responses of pediatric and adult patients to see if these factors contribute severity dichotomy. Children's non-specific profile is dominated by naive lymphocytes HLA-DR
Changes in the epidemiology of respiratory infections during restrictions imposed as a response to coronavirus disease 2019 (COVID-19) pandemic have been reported elsewhere. The present study's aim was describe prevalence large array pathogens symptomatic children and adolescents Southern Brazil.Hospitalized outpatients aged 2 months 18 years with signs symptoms acute COVID-19 were prospectively enrolled study from May November 2020 two hospitals metropolitan area Brazilian city. All...
<title>Abstract</title> • <bold>Background</bold>: Asthma is one of the most prevalent chronic pulmonary diseases, affecting approximately 20 million Brazilian people. Most patients with asthma in Brazil present uncontrolled disease, leading to high morbidity and mortality rates. Therefore, an effective educational intervention focused on management Primary Health Care (PHC) expected reduce hospitalization rates, emergency visits, direct public health costs, improving quality life patients....
The viral dynamics and the role of children in spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values among with confirmed SARS-CoV-2 compared that adult subjects.Patients (from months ≤18 years age adults) signs symptoms infection for less than 7 days were prospectively enrolled study from May November 2020. All participants performed...
Abstract Background The viral dynamics and the role of children in spread SARS-CoV-2 are not completely understood. Our aim was to evaluate RT-PCR Ct values among with confirmed compared that adult subjects. Methods Patients (aged from 2 months ≤18 years, adults) signs symptoms acute infection for less than 7 days, were prospectively enrolled study May November 2020. All participants performed assay detection; ORF1ab, N, S gene-targets, average all three probes used as surrogates load....
This is the third year of SARS-CoV-2 pandemic, and yet most children remain unvaccinated. COVID-19 in manifests as mostly mild or asymptomatic, however high viral titers strong cellular humoral responses are observed upon acute infection. It still unclear how long these persist, if they can protect from re-infection and/or disease severity. Here, we analyzed immune memory a cohort adults with COVID-19. Important differences between evident kinetics profile responses. Children develop early...
to evaluate the accuracy of an antibody point-of-care lateral flow immunoassay (LFI - Wondfo Biotech Co., Guangzhou, China) in a pediatric population.children and adolescents (2 months 18 years) with signs symptoms suggestive acute SARS-CoV-2 infection were prospectively investigated nasopharyngeal RT-PCR LFI at emergency room. was performed baseline, same time or scheduled for those less than 7 days clinical picture. Overall accuracy, sensitivity specificity assessed, as well according...
Point-of-care serological tests for SARS-CoV-2 have been used COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess a point-of-care lateral flow immunoassay (LFI). Subjects, aged 18 years, presenting clinical suggestive acute infection were tested once by both nasopharyngeal and oropharyngeal RT-PCR LFI. The LFI was assessed in periodic intervals three days relation symptoms. optimal cut-off point defined as number...
Abstract Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not characterized. It is still unclear how frequently get infected, and/or generate immune responses SARS-CoV-2. We performed profiling of pediatric and adult patients Brazil, producing over 38 thousand data points, asking if cellular or humoral could help explain children. In study, presented...
Abstract Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not characterized. It is still unclear how frequently get infected, and/or generate immune responses SARS-CoV-2. We performed profiling of pediatric and adult patients Brazil, producing over 38 thousand data points, asking if cellular or humoral could help explain children. In study, presented...
Abstract Background/Objectives The aim of this study was to evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients Brazil. Subjects/Methods Adults with signs symptoms suggestive acute SARS-CoV-2 infection who sought two hospitals (one public one private) emergency department (ED) were prospectively enrolled. Patients confirmed at inclusion followed by phone calls day (D) D7, D14 D28. Multivariable logistic regression models employed explore other...
O Streptococcus pneumoniae é uma das principais bactérias associadas a coinfecções virais. Informações quanto à colonização pneumocócica e são limitadas, incluindo possível associação com SARS-CoV-2. objetivo deste estudo foi descrever as frequências de S. identificação outros agentes respiratórios patogênicos comuns, durante o primeiro ano da pandemia COVID-19. Estudo observacional prospectivo em participantes idade >10 anos, sintomas respiratórios, entre maio novembro/2020. Foi realizado...
Streptococcus pneumoniae é um importante colonizador nasofaríngeo, e potencial causador de infecções graves invasivas em crianças. Desde 2010, a vacina pneumocócica conjugada 10 (PVC-10) está disponível pelo Programa Nacional Imunizações. O objetivo deste estudo foi descrever colonização S. identificar outros patógenos durante o primeiro ano da pandemia COVID-19. Foram recrutados observacional prospectivo, crianças (≤10 anos) dois hospitais do Sul Brasil entre maio novembro 2020. A presença...
Apesar do predomínio SARS-CoV-2 como etiologia das infecções virais em adultos durante o ano de 2020, outros agentes infecciosos podem fazer parte diagnóstico diferencial. O objetivo deste estudo foi descrever a prevalência dos patógenos respiratórios internados dois hospitais no sul Brasil pandemia e comparar os desfechos gravidade na internação entre participantes com COVID-19 comparado infecciosos. Participantes (> 18 anos) hospitalizados sinais agudos tosse, febre ou dor garganta foram...
Os fatores associados ao risco de hospitalização por COVID19 não são completamente conhecidos. O objetivo deste estudo foi descrever o dos participantes ambulatoriais com diagnóstico exclusivo para rinovírus, SARS-CoV-2 e codetecção entre esses dois agentes, durante a pandemia no sul do Brasil. Participantes (> 18 anos) sinais agudos tosse, febre ou dor garganta foram recrutados prospectivamente nas tendas atendimento Hospital Moinhos Vento Restinga Extremo Sul, maio novembro 2020,...
To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients Brazil.Adults with signs symptoms suggestive of acute SARS-CoV-2 infection who sought treatment two hospital (public private) emergency departments were prospectively enrolled. Patients confirmed at inclusion followed by phone calls days D7, D14 D28. Multivariable logistic regression models employed to explore other potential predictors for hospitalization.A total 1,050 participants screened,...
Abstract Background The emergence of SARS-CoV-2 variants is a current public health concern possibly impacting COVID-19 disease diagnosis, transmission patterns and vaccine effectiveness. Objectives To describe the lineages circulating early pandemic among samples with S gene dropout characterize novel mutation in receptor-binding domain (RBD) viral spike protein. Study design Adults children older than 2 months signs symptoms were prospectively enrolled from May to October 2020 Porto...