A5042204528- Heat shock proteins research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Adenosine and Purinergic Signaling
- Respiratory viral infections research
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- thermodynamics and calorimetric analyses
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Science and Education Research
- CAR-T cell therapy research
- Asthma and respiratory diseases
Universidade Federal de Ciências da Saúde de Porto Alegre
2019-2024
University of California, San Diego
2017-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2009-2018
La Jolla Alcohol Research
2018
Institut de Biologie Moléculaire et Cellulaire
2014
Instituto Nacional do Câncer
2013
Universidade Federal do Rio Grande do Sul
1993-2010
Hospital São Lucas da PUCRS
2003
National Jewish Health
1997
University of Colorado Denver
1997
Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such is only now becoming clear. In experimental disease models, Hsp administration can prevent or arrest damage, and initial clinical trials patients with chronic diseases, peptides have been shown promote production anti-inflammatory cytokines, indicating immunoregulatory potential Hsp. Therefore, presence immune diseases be seen as an attempt system correct condition....
Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children first year of life. RSV generates large numbers hospitalizations and an important burden to health systems. Neutrophils their products are present airways RSV-infected patients who developed increased lung disease. Neutrophil Extracellular Traps (NETs) formed release granular nuclear contents neutrophils extracellular space response different stimuli recent studies have proposed...
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess difference cellular or humoral immune responses of pediatric and adult patients to see if these factors contribute severity dichotomy. Children's non-specific profile is dominated by naive lymphocytes HLA-DR
Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution infection, yet these cells are involved in perpetuation different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) a neuropeptide that acts through G protein coupled receptors (GPCRs) signal transmission central peripheral nervous systems. Its receptor, gastrin-releasing receptor (GRPR), expressed by various cell types, it overexpressed cancer cells. RC-3095 selective GRPR...
<b><i>Background:</i></b> Some premature features of immunosenescence have been associated with persistent viral infections and altered populations T cells. In particular, the inverted CD4:CD8 ratio has correlated increased morbidity mortality across different age groups. <b><i>Objective:</i></b> Here, we investigated role infections, cognitive functional states as predictors older adults in a developing country....
Abstract Purinergic signaling modulates immune function and is involved in the immunopathogenesis of several viral infections. This study aimed to investigate alterations purinergic pathways coronavirus disease 2019 (COVID‐19) patients. Mild severe COVID‐19 patients had lower extracellular adenosine triphosphate levels, higher cytokines than healthy controls. presented frequencies CD4 + CD25 CD39 (activated/memory regulatory T cell [mTreg]) increased high‐differentiated (CD27 − CD28 ) CD8...
Pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of pancreatic neoplasms, is characterized by its poor prognosis, with a 5-year survival rate only 12%. Most patients are diagnosed metastatic or locally advanced disease, leaving 15% eligible curative resection. PDAC exhibits resistance to chemotherapy, targeted therapies, and immunotherapy, largely due highly heterogeneous tumor microenvironment (TME). In this study, we performed an integrative analysis publicly available scRNA,...
Summary In different inflammatory disease models, heat‐shock proteins (hsp) and hsp‐derived peptides have been demonstrated to possess anti‐inflammatory properties. While some studies shown that hsp can directly interact with antigen‐presenting cells, others report bacterial induce specific T cells regulatory phenotypes. Effective characterization of the immunomodulatory effects 70, however, has historically confounded by lipopolysaccharide (LPS) contamination. this study, we compared...
Abstract Background Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses that contribute to progression injury. Impaired calcium (Ca 2+ ) homeostasis a hallmark acetaminophen (APAP)-induced hepatotoxicity, since induces mobilization intracellular Ca stocks, we...
Purpose: Extracellular Hsp70 has anti-inflammatory potential, demonstrated in different models of inflammatory diseases. We investigated probable mechanisms used by to down-regulate pro-inflammatory cytokines.
SUMMARY Cytokines are key modulators of the immune responses that take place in inflamed synovium arthritis patients. Consequently, substances can reverse inflammatory profile joint potential tools for clinical management disease. Mycobacterial heat shock protein 70 (MTBHSP70) has been found to protect rats from experimentally induced through induction interleukin (IL)-10-producing T cells. In this study, we have demonstrated MTBHSP70 induces IL-10 production synoviocytes patients and...