A5064257070- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Acute Lymphoblastic Leukemia research
- Medicinal Plants and Neuroprotection
- Immune Response and Inflammation
- Cancer-related cognitive impairment studies
- Autism Spectrum Disorder Research
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- Cardiac tumors and thrombi
Universidade Federal do Rio Grande do Sul
2009-2021
Hospital de Clínicas de Porto Alegre
2009-2019
Univates
2016
Centro Universitário Metodista IPA
2015
National Institute on Population Medical Genetics
2010-2013
Instituto do Cérebro
2008-2013
GTx (United States)
2013
Cancer Institute (WIA)
2011
Center for Translational Molecular Medicine
2011
Institute of Cancer Research
2010
Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution infection, yet these cells are involved in perpetuation different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) a neuropeptide that acts through G protein coupled receptors (GPCRs) signal transmission central peripheral nervous systems. Its receptor, gastrin-releasing receptor (GRPR), expressed by various cell types, it overexpressed cancer cells. RC-3095 selective GRPR...
Background Large cooperative group studies have shown the efficacy of risk-adapted treatment for Ewing sarcoma. However, validation and local adaptation by National groups is needed. A multicenter protocol to determine safety a intensive regimen was developed Brazilian group. Procedure Patients <30 years old with sarcoma were eligible. Induction chemotherapy consisted two cycles ICE (ifosfamide, carboplatin, etoposide) followed VDC (vincristine, doxorubicin, cyclophosphamide), control. low...
Gliomas are the most incident brain tumor in adults. This malignancy has very low survival rates, even when combining radio- and chemotherapy. Among gliomas, glioblastoma multiforme (GBM) is common aggressive type, patients frequently relapse or become refractory to conventional therapies. The fact that such an can arise a carefully orchestrated organ, where cellular proliferation barely needed maintain its function, question intrigued scientists until recently, discovery of existence...
The clinical success of targeted treatment colorectal cancer (CRC) is often limited by resistance to anti-epidermal growth factor receptor (EGFR) therapy. neurotrophin brain-derived neurotrophic (BDNF) and its TrkB have recently emerged as anticancer targets, we previously shown increased BDNF levels in CRC tumor samples. Here report the findings from vitro experiments suggesting that BDNF/TrkB signaling can protect cells antitumor effects EGFR blockade. anti-EGFR monoclonal antibody...
<i>Objective:</i> Neurotrophin and neuropeptide pathways are emerging targets in cancer. Here we show that brain-derived neurotrophic factor (BDNF) its receptor, TrkB, present colorectal cancer BDNF levels increased tumors compared to nontumor tissue. In addition, investigate the role of influencing response cells inhibition gastrin-releasing peptide receptors (GRPR). <i>Methods:</i> Fresh-frozen sporadic adenocarcinoma specimens adjacent nonneoplastic tissue from 30...
Medulloblastoma (MB) is the most common malignant brain tumor in children and occurs mainly cerebellum. Important intracellular signaling molecules, such those present Sonic Hedgehog Wnt pathways, are involved its development can also be employed to determine grade prognosis. Ectonucleotidases, particularly ecto-5′NT/CD73, important enzymes process of different types regulating extracellular ATP adenosine levels. Here, we investigated activity ectonucleotidases three human cell lines: Daoy...
Abstract Background Cisplatin may cause permanent cochlear damage by changing frequency selectivity and can lead to irreversible sensorineural hearing loss. High‐frequency audiometry (HFA) is able assess frequencies above 8,000 Hz; hence, it has been considered a high‐quality method monitor diagnose early asymptomatic signs of ototoxicity in patients receiving cisplatin. Procedure Forty‐two pediatric were evaluated for loss induced cisplatin utilizing HFA, its diagnostic efficacy was...
Epigenetic deregulation may be involved in tumor cell biology, including differentiation, progression, and death, histone acetylation is a major regulatory mechanism of gene transcription. Patterns global modifications have been recently suggested as outcome predictors cancer patients, but few studies conducted on pancreatic ductal adenocarcinomas (PDACs). This study was designed to investigate the predictive value PDAC.A retrospective clinicopathologic analysis undertaken 119 patients...
Background Ecto-5'-nucleotidase/CD73 (ecto-5'-NT) participates in extracellular ATP catabolism by converting adenosine monophosphate (AMP) into adenosine. This enzyme affects the progression and invasiveness of different tumors. Furthermore, expression ecto-5'-NT has also been suggested as a favorable prognostic marker, attributing to this contradictory functions cancer. Medulloblastoma (MB) is most common brain tumor cerebellum mainly children. Materials Methods The effects overexpression...
A large number of plants are known to possess strong antitumor properties. Previous studies have verified the antiproliferative activity extracts and fractions from six species Hypericum spp. growing in southern Brazil. In present study, in-vitro effects two dimeric phloroglucinols (japonicin uliginosin B, isolated myrianthum) benzophenones (cariphenone cariphenone H. carinatum) were investigated against three tumor cell lines (HT-29 - human colon carcinoma cells; U-251 glioma line, OVCAR-3...