A5048395719- Diabetes and associated disorders
- Adenosine and Purinergic Signaling
- Diabetes Management and Research
- Traditional and Medicinal Uses of Annonaceae
- Digestive system and related health
- Immune Cell Function and Interaction
- Alkaloids: synthesis and pharmacology
- Oral microbiology and periodontitis research
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Infant Nutrition and Health
- Bioactive Compounds and Antitumor Agents
- Bioactive natural compounds
- Genetics and Neurodevelopmental Disorders
- Tendon Structure and Treatment
- Neuroendocrine Tumor Research Advances
- Wnt/β-catenin signaling in development and cancer
- Synthesis and Biological Activity
- Myasthenia Gravis and Thymoma
- Cancer Mechanisms and Therapy
- Plant-based Medicinal Research
- Pancreatic and Hepatic Oncology Research
- Exercise and Physiological Responses
- Genomics, phytochemicals, and oxidative stress
Linköping University
2018-2023
Universidade Federal do Rio Grande do Sul
2012-2022
Instituto de Saúde
2015
OBJECTIVE To evaluate the efficacy of aluminum-formulated intralymphatic glutamic acid decarboxylase (GAD-alum) therapy combined with vitamin D supplementation in preserving endogenous insulin secretion all patients type 1 diabetes (T1D) or a genetically prespecified subgroup. RESEARCH DESIGN AND METHODS In multicenter, randomized, placebo-controlled, double-blind trial, 109 aged 12–24 years (mean ± SD 16.4 4.1) duration 7–193 days (88.8 51.4), elevated serum GAD65 autoantibodies, and...
Abstract Aims Residual beta cell function in type 1 diabetes (T1D) is associated with lower risk of complications. Autoantigen therapy GAD-alum (Diamyd) given 3 intralymphatic injections oral vitamin D has shown promising results persons T1D carrying the human leukocyte antigen (HLA) DR3-DQ2 haplotype phase 2b trial DIAGNODE-2. We aimed to explore efficacy on blood glucose recorded by continuous monitoring (CGM). Methods DIAGNODE-2 (NCT03345004) was a multicenter, randomized,...
Medulloblastoma (MB) is the most common malignant brain tumor in children and occurs mainly cerebellum. Important intracellular signaling molecules, such those present Sonic Hedgehog Wnt pathways, are involved its development can also be employed to determine grade prognosis. Ectonucleotidases, particularly ecto-5′NT/CD73, important enzymes process of different types regulating extracellular ATP adenosine levels. Here, we investigated activity ectonucleotidases three human cell lines: Daoy...
In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation residual beta cell function makes the disease milder, facilitates treatment, prevents complications and increase survival. So far immune interventions have had limited effect, some adverse events risks. an open pilot trial we aimed improve efficacy GAD-alum using lymph-node administration in combination with oral vitamin D. Here report clinical effect focus on biomarkers for response treatment....
Bladder cancer is the second most prevalent malignancy in genitourinary tract and remains a therapeutic challenge. In search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal mind, Uncaria tomentosa noteworthy because bark root of species are widely used traditional medicine adjuvant therapy treatment numerous diseases. The objective study was investigate antitumor effect one purified bioactive fraction U. on cell proliferation two human...
Abstract Aim To evaluate the long-term effect of intra-lymphatic administration GAD-alum and a booster dose 2.5 years after first intervention (DIAGNODE Extension study) in patients with recent-onset type 1 diabetes. Methods DIAGNODE-1: Samples were collected from 12 30 months who had received 3 injections 4 μg into lymph node one-month interval. DIAGNODE study: First human, fourth autoantigen (GAD-alum) was given to at 31.5 months, followed for another months. C-peptide measured during...
GAD-alum given into lymph nodes to Type 1 diabetes (T1D) patients participating in a multicenter, randomized, placebo-controlled double-blind study seemed have positive effect for with DR3DQ2 haplotype, who showed better preservation of C-peptide than the placebo group. Here we compared immunomodulatory administered T1D versus focus on haplotype. Methods GAD autoantibodies, GADA subclasses, 65 -induced cytokine secretion (Luminex panel) and proliferation peripheral mononuclear cells were...
Background Ecto-5'-nucleotidase/CD73 (ecto-5'-NT) participates in extracellular ATP catabolism by converting adenosine monophosphate (AMP) into adenosine. This enzyme affects the progression and invasiveness of different tumors. Furthermore, expression ecto-5'-NT has also been suggested as a favorable prognostic marker, attributing to this contradictory functions cancer. Medulloblastoma (MB) is most common brain tumor cerebellum mainly children. Materials Methods The effects overexpression...
Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) an inflammatory condition bladder associated with use anticancer drugs cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been to prevent occurrence HE, although this compound not effective established lesions. It demonstrated that purinergic system involved several pathophysiological events. Among receptors, P2X7 deserves...
The antitumor activity of <i>Uncaria tomentosa</i>, a native vine from the Amazonian rainforest, has been ascribed to pentacyclic oxindole alkaloids occurring in its bark. Former studies have shown that this activity, as well intensity, depends on whether cat's claw occur original compounds or isomerized derivatives. This work addresses aspect, using T24 and RT4 human bladder cancer cell lines for purpose. Bark samples were extracted by dynamic maceration, prepurified with cross-linked...
Abstract Aims Immunomodulation with autoantigens potentially constitutes a specific and safe treatment for type 1 diabetes (T1D). Studies GAD‐alum administrated subcutaneously have shown to be safe, but its efficacy has been inconclusive. Administration of into the lymph nodes, aimed optimise antigen presentation, promising results in an open‐label clinical trial. Herein, we compared immune response individuals included trial group who received previous study. Materials methods Samples from...
Background: The immune system reflects the microbiome (microbiota). Modulation of during early tendon remodeling by dexamethasone treatment can improve rat Achilles healing. authors tested whether changes in microbiota could influence effect treatment. Hypothesis: A change would response to on regenerate remodeling, specifically material properties (peak stress). Study Design: Controlled laboratory study. Methods: Specific opportunist and pathogen-free female rats were housed separately (n =...
4-Methylcoumarins were synthesized by microwave-assisted synthesis <italic>via</italic> Pechmann condensation and their cytotoxic activity against human bladder cancer cell lines was investigated.
We present the rare case of a solitary pancreatic metastasis renal cell cancer being only manifestation tumordissemination. In 1993 patient underwent transperitoneal nephrectomy for removal clear cancer. 1998 during follow up we detected tumor which was treated by pancreas resection, splenectomy and resection colon transversum. The histology revealed previously resected postoperative recovery impaired development an abscess in former region. During first year did not find any signs local or...
<b>Objectives:</b> To evaluate the efficacy of intra-lymphatic GAD-alum therapy together with vitamin D supplementation on preserving endogenous insulin secretion in all patients Type 1 diabetes (T1D) or a genetically pre-specified subgroup. <p><b>Research Design and Methods:</b> In multicenter, randomized, placebo-controlled double-blind trial (NCT03345004), 109 aged 12-24 (16.4 ± 4.1) years duration 7-193 (88.8 51.4) days, elevated serum GAD65 autoantibodies...