A5057127964- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Phytochemistry Medicinal Plant Applications
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Research on Leishmaniasis Studies
- Heavy Metals in Plants
- Malaria Research and Control
- Insect Pest Control Strategies
- Biochemical and Structural Characterization
- Bacterial biofilms and quorum sensing
- Plant Toxicity and Pharmacological Properties
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Nail Diseases and Treatments
- Bioactive Compounds and Antitumor Agents
- Fungal Infections and Studies
- Phytochemistry and Biological Activities
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Chemical Synthesis and Analysis
Universidade Federal do Rio Grande do Sul
2014-2023
Instituto de Ciências Farmacêuticas
2018
Kyoto University Research Reactor Institute
2008
The University of Tokyo
2008
Centre National de la Recherche Scientifique
2008
Université de Picardie Jules Verne
2007-2008
Universidade Federal de Santa Catarina
2004
Dermatomycosis causes highly frequent dermal lesions, and volatile oils have been proven to be promising as antifungal agents. The activity of geraniol, nerol, citral, neral geranial (monoterpenes), terbinafine anidulafungin (control drugs) against seven opportunistic pathogenic yeasts four dermatophyte species was evaluated by the Clinical Laboratory Standards Institute microdilution tests. Monoterpenes were more active dermatophytes than (geometric mean minimal inhibitory concentration...
More than 40% of the World population is at risk contracting malaria, which affects primarily poor populations in tropical and subtropical areas. Antimalarial pharmacotherapy has utilised plant-derived products such as quinine artemisinin well their derivatives. However, worldwide use these antimalarials caused spread resistant parasites, resulting increased malaria morbidity mortality. Considering that literature demonstrated antimalarial potential triterpenes, specially betulinic acid (1)...
Ilex paraguariensis St. Hilaire is a South American tree from which leaves and twigs are used to prepare commonly consumed tea in several countries. The plant known as "erva-mate" Portuguese or "yerba mate" Spanish. Considering the potential use of saponins surfactant well its therapeutic potential, present work was designed propose extraction quantitation methods for paraguariensis. were extracted by decoction, hydrolyzed quantified HPLC method with UV detection. concentration expressed...
Baccharis trimera is a plant popularly used as tea and to treat gastrointestinal diseases inflammatory processes well. The total phenolic content was determined the antioxidant anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin phenolic) from B. were evaluated. Using carrageenan-induced pleurisy model acute inflammation, extract at 15 mg/kg decreased significantly analyzed parameters when compared carrageenan group ( p < 0.05), thus...
New medicines for the treatment of bacterial biofilm formation are required. For this reason, study shows in vitro activity betulinic acid (BA), ursolic (UA) and their twenty derivatives against planktonic cells (gram-positive pathogens: Enterococcus faecalis, Staphylococcus aureus epidermidis). We evaluated antibiofilm (through crystal violet method), as well antibacterial via absorbance (OD600) at concentrations 5, 25 100 µM. Likewise, cytotoxicity all compounds was on a kidney African...
Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory antioxidant properties that are related to the presence of phenolic compounds. The aim this work was investigate anti-proliferative (PHE) terpenoid (SAP) compounds from B. on human cervical cancer. treatment SiHa cells with PHE 24 h suppressed colony formation dose-dependent manner, inhibited proliferation cell motility. Although SAP it increased did not inhibit also promoted...
Abstract Background The discovery and development of anti-malarial compounds plant origin semisynthetic derivatives thereof, such as quinine (QN) chloroquine (CQ), has highlighted the importance these in treatment malaria. Ursolic acid analogues bearing an acetyl group at C-3 have demonstrated significant activity. With this mind, two new series betulinic (BA) ursolic (UA) with ester groups were synthesized attempt to improve activity, reduce cytotoxicity, search for targets. In vitro...
The triterpene chikusetsusaponin IVa was isolated from the fruit of Ilex paraguariensis. Using biochemical and pharmacological methods, we demonstrated that (1) prolongs recalcification time, prothrombin activated partial thromboplastin thrombin time normal human plasma in a dose-dependent manner, (2) inhibits amidolytic activity factor Xa upon synthetic substrates S2238 S2222, (3) thrombin-induced fibrinogen clotting (50% inhibition concentration, 199.4 ± 9.1 μM), (4) thrombin-...
Abstract Objectives To semisynthesise piperazine derivatives of betulinic acid to evaluate antimalarial activity, cytotoxicity and action mechanism. Methods The new were evaluated against the CQ ‐sensitive Plasmodium falciparum 3D7 strain by flow cytometry ( FC ) using YOYO ‐1 as stain. Cytotoxicity 4a 4b was performed with HEK 293T cells for 24 48 h MTT assay. capability compound modulate Ca 2+ in trophozoite stage investigated. trophozoites stained Fluo4‐ AM analysed spectrofluorimetry....
Insecticide resistance to commonly used substances demands new molecules for the chemical control of dengue vector Aedes aegypti. Because natural product sources have been an alternative obtain larvicidal compounds, aim this study was evaluate triterpenoids betulinic (BA) and ursolic (UA) acids their semi-synthetic derivatives against larval Ae. BA, UA, ten modified at C-3 position a positive (diflubenzuron) were evaluated. Larvicidal assays carried out with early fourth-instar larvae,...
A series of new ursolic and oleanolic acids derivatives was synthesized via or acids, previously extracted from South American Ilex species. These compounds were tested for in vitro antiparasitic activity on Leishmania amazonensis infantum strains. Some these showed against the promastigote forms L. infantum, with IC50 ranging 5 to 12 μM. As expected, most a significant level cytotoxicity monocytes (IC50 = 2-50 μM). From structure-activity relationships point view, pharmacological results...
MATÉ (Ilex paraguariensis A. ST.-HIL., AQUIFOLIACEAE).Ilex A
Emerging yeasts are among the most prevalent causes of systemic infections with high mortality rates and there is an urgent need to develop specific, effective non-toxic antifungal agents respond this issue. In study 35 aldehydes, hydrazones hydrazines were obtained their activity was evaluated against Candida species (C. parapsilosis, C. tropicalis, krusei, albicans, glabrata lusitaneae) Trichosporon asahii, in vitro screening. The minimum inhibitory concentrations (MICs) active compounds...