A5024328896- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Phytochemistry Medicinal Plant Applications
- Thyroid Disorders and Treatments
- Plant tissue culture and regeneration
- Neonatal Health and Biochemistry
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Pharmacological Effects and Toxicity Studies
- Peptidase Inhibition and Analysis
- Agricultural and Food Sciences
- French Urban and Social Studies
- Lysosomal Storage Disorders Research
- Nuts composition and effects
- Plant-Derived Bioactive Compounds
- Vaccine Coverage and Hesitancy
- Bipolar Disorder and Treatment
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Infectious Diseases and Mycology
- Adhesion, Friction, and Surface Interactions
- Brucella: diagnosis, epidemiology, treatment
- Beetle Biology and Toxicology Studies
- COVID-19 Impact on Reproduction
University of Palermo
2023
Marche Polytechnic University
2022-2023
Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul
2010-2022
Universidade Federal do Rio Grande do Sul
2002-2021
Universidade Federal de Ciências da Saúde de Porto Alegre
2006
Pregnant women are at higher risk of severe Coronavirus disease 2019 (COVID-19) complications than non-pregnant women. The initial exclusion pregnant from anti-SARS-CoV-2 vaccines clinical trials has caused a lack conclusive data about safety and efficacy for this vulnerable population. This cross-sectional study aims to define the factors related vaccination adherence in sample experiencing high-risk pregnancies. recruited completed questionnaire based on Health Belief Model. Data were...
In cervical cancer, HPV infection and disruption of mechanisms involving cell growth, differentiation, apoptosis are strictly linked with tumor progression invasion. Tumor microenvironment is ATP adenosine rich, suggesting a role for purinergic signaling in cancer growth death. Here we investigate the effect extracellular on human cells. We find that itself has small cytotoxic effect, whereas formed from degradation by ectonucleotidases main factor responsible induction. The level P2 × 7...
Lubricant-infused surfaces (LISs) and slippery liquid-infused porous (SLIPSs) have shown remarkable success in repelling low-surface-tension fluids. The atomically smooth, defect-free surface leads to reduced droplet pinning omniphobicity. However, the presence of a lubricant introduces liquid–liquid interactions with working fluid. commonly utilized lubricants for LISs SLIPSs, although immiscible water, show various degrees miscibility organic polar nonpolar Here, we rigorously investigate...
Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory antioxidant properties that are related to the presence of phenolic compounds. The aim this work was investigate anti-proliferative (PHE) terpenoid (SAP) compounds from B. on human cervical cancer. treatment SiHa cells with PHE 24 h suppressed colony formation dose-dependent manner, inhibited proliferation cell motility. Although SAP it increased did not inhibit also promoted...
Dipeptidyl peptidase IV (DPPIV/CD26) is a transmembrane glycoprotein that inactivates or degrades some bioactive peptides and chemokines. For this reason, it regulates cell proliferation, migration adhesion, showing its role in cancer processes. This enzyme found mainly anchored onto the membrane, although also has soluble form, an enzymatically active isoform. In present study, we investigated DPPIV/CD26 activity expression cervical lines (SiHa, HeLa C33A) non-tumorigenic HaCaT cells. The...
Abstract The influence of the thyroid hormones on normal function mammalian central nervous system depends brain region and developmental stage. Adenine nucleotides their products also affect function; ATP is an excitatory neurotransmitter, adenosine has inhibitory effects neurotransmission. Thus, this study aimed to evaluate hypothyroidism hydrolysis in hippocampal cortical synaptosomes blood serum rats during different phases development. Rats aged 60 420 days old were divided into three...
Abstract Adenosine, a well‐known neuromodulator, can act as an endogenous anticonvulsant via the activation of adenosine A 1 receptors. This adenine nucleoside be produced in synaptic cleft by ectonucleotidase cascade, which includes triphosphate diphosphohydrolase (NTPDase) family and ecto‐5′‐nucleotidase. It has been previously reported that activities are increased female adult rats submitted to pilocarpine model epilepsy. Several studies have suggested immature brain is less vulnerable...
Cervical cancer is the third most frequent in women worldwide. Adenine nucleotide signaling modulated by ectonucleotidases that act sequence, forming an enzymatic cascade. Considering relationship between purinergic and cancer, we studied E-NTPDases, ecto-5'-nucleotidase, E-NPPs human cervical cell lines keratinocytes. We evaluated expression profiles of these enzymes using RT-PCR quantitative real-time PCR analysis. The activities were examined ATP, ADP, AMP, p-nitrophenyl-5'-thymidine...
Abstract The present study aimed to determine the chemical composition and biological activity of essential oil obtained from Phyllogonium viride Brid. (Phyllogoniaceae, Bryophyta), whose samples were collected in southern Brazil. For first time, cytotoxic P. breast colorectal tumor cells (MCF‐7 HCT‐116) was evaluated, as well potential this non‐tumoral human immortalized keratinocytes (HaCaT) via MTT assay. compounds majorly found β‐bazzanene (20.30 %), β‐caryophyllene (17.06 β‐chamigrene...
(1) Background: The value of dual-energy CT angiography (DE-CTA) in the detection peripheral arterial disease (PAD) has been widely recognized. We aim to evaluate diagnostic accuracy virtual non-contrast (VNC) imaging DE-CTA compared true phase (TNC). (2) Methods: Our Internal Review Board (IRB) approved prospective study enrolled 40 patients (28 men, 12 women; median age 69 y, range 41–93 y) who underwent lower extremity for symptomatic PAD. Mean attenuation values TNC and VNC were obtained...
Abstract Here we investigate the possible effects of hyperthyroidism on hydrolysis ATP to adenosine in synaptosomes hippocampus, cerebral cortex and blood serum rats different developmental phases. Manifestations include anxiety, nervousness, tachycardia, physical hyperactivity weight loss amongst others. The thyroid hormones modulate a number physiological functions central nervous system, including development, function, expression A 1 receptors transport neuromodulator adenosine. Thus,...
The effects of ATP, ADP, and adenosine in the processes platelet aggregation, vasodilatation, coronary flow have been known for many years. sequential hydrolysis ATP to by soluble nucleotidases constitutes main system rapid inactivation circulating adenine nucleotides. Thyroid disorders affect a number biological factors including levels different fractions. Then, we intend investigate if responsible AMP are affected variations thyroid hormone blood serum from adult rats. Hyperthyroidism was...
Reports from popular medicine usually act as a basis for the development of new drugs natural compounds with therapeutic actions serious diseases and prevalence such cancer. Bromelia antiacantha Bertol. is species Bromeliaceae family, considered an unconventional food plant, found in south midwest regions Brazil. Despite high nutritional content pharmacological potential its fruits, few scientific studies report biological actions. Thus, this study evaluates phytochemical profile aqueous...
Breast and cervical cancer represent a major problem of women's global public health. Here, we investigated the chemical composition essential oils from leaves flowers T. ostenii antineoplastic potential in breast cell line, SiHa MCF-7; non-tumoral cells, HaCat. The analysis revealed predominance oxygenated monoterpenes both oils. IC50 after 24 h treatment was 72 ng/mL for EO 1 83 2 cells. For MCF-7 174.3 1. HaCat cells it 54.45 20.83 2. A synergistic effect with cisplatin also verified. had...
The COVID-19 pandemic caused a reduction in vaccination coverage for all age groups, especially non-infant age. main objective of the present study is to evaluate effectiveness an online intervention conducted among adolescents during increasing knowledge and positive attitudes toward vaccinations. study, which took place from March May 2021, involved 267 students six lower secondary schools Palermo city (Italy); they filled out questionnaire before after intervention. was based on...