A5063926465- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Antioxidant Activity and Oxidative Stress
- Treatment of Major Depression
- Education and Public Policy
- Essential Oils and Antimicrobial Activity
- Environmental Sustainability and Education
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Neuroscience and Neuropharmacology Research
- Business and Management Studies
- Vitamin C and Antioxidants Research
- Biochemical Analysis and Sensing Techniques
- Free Radicals and Antioxidants
- Psidium guajava Extracts and Applications
- Medicinal Plants and Neuroprotection
- Advanced Synthetic Organic Chemistry
- Phytochemistry Medicinal Plant Applications
- Retinoids in leukemia and cellular processes
- Antifungal resistance and susceptibility
- Microbial Metabolism and Applications
- Bioactive Compounds and Antitumor Agents
- Carcinogens and Genotoxicity Assessment
Universidade Federal de Pelotas
2013-2022
Leonardo (United Kingdom)
2022
Universidade Federal da Grande Dourados
2014
Centre National de la Recherche Scientifique
2008-2014
Université de Picardie Jules Verne
2008-2014
Universidade Federal do Rio Grande do Sul
2001-2011
Abstract Objectives Eugenol, obtained from clove oil (Eugenia caryophyllata), possess several biological activities. It is anti-inflammatory, analgesic, anaesthesic, antipyretic, antiplatelet, anti-anaphylactic, anticonvulsant, anti-oxidant, antibacterial, antidepressant, antifungal and antiviral. The anti-oxidant activity of eugenol have already been proven. From this perspective testing, a series planned structural derivatives were screened to perform optimization consequent increase the...
Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, aim present study was to evaluate effects extracts from fruits native Brazil on metabolic parameters and hepatic oxidative markers animal model insulin induced by dexamethasone (DEX).Wistar rats received water or Eugenia uniflora Psidium cattleianum, once a day for 21 days. For last 5 days, intraperitoneal injection saline DEX.DEX caused reduction body weight gain...
The aim of the present study was to evaluate protective effects blueberry extract on oxidative stress and inflammatory parameters in a model mania induced by ketamine administration rats. Male rats were pretreated with (200 mg/kg, once day for 14 days), lithium chloride (45 mood stabilizer used as positive control, twice or vehicle. Between 8th 14th days, also received an injection (25 mg/kg) In 15th day, thirty minutes after hyperlocomotion animals assessed open – field apparatus....
Pyrazoles are compounds of synthetic origin, and constitute a group nitrogen heterocyclic that have shown several biological activities. Their transformations into other biologically active molecules been exploited since the early 1960s. This review describes work on environment-friendly synthesis bioactive pyrazoles. The covers mainly data published over last five years (2007–2012).
A series of new ursolic and oleanolic acids derivatives was synthesized via or acids, previously extracted from South American Ilex species. These compounds were tested for in vitro antiparasitic activity on Leishmania amazonensis infantum strains. Some these showed against the promastigote forms L. infantum, with IC50 ranging 5 to 12 μM. As expected, most a significant level cytotoxicity monocytes (IC50 = 2-50 μM). From structure-activity relationships point view, pharmacological results...
The antibiofilm and antibacterial properties against Pseudomonas aeruginosa Staphylococcus epidermidis chemical characterization of six hydroethanolic blueberry extracts (blueberry rabbiteye—Vaccinium virgatum) from different cultivars means propagation were investigated. total flavonoid, anthocyanin, phenolic contents determined by specific well-established methods. Among the cultivars, Briteblue showed lowest content all metabolites analyzed, while Bluegem highest concentrations these...
Abstract The determination of cholinesterase activity in plasma and erythrocytes serves as a useful sensitive biomarker exposure to organophosphorus carbamate pesticides. However, acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) may be influenced by factors such age, gender, drugs, physical exercise. aim this study was evaluate the effects gender exercise on AChE BuChE healthy individuals. values for both enzymes were lower women. Physical increased levels BuChE, had no significant...
Because of the need for more effective and less harmful antifungal therapies, interest in synthesis new carboximidamides, goal this study was to determine anti-enzyme activities some pyrazole carboximidamides their cytotoxicity. For purpose, tests were performed evaluate: minimum inhibitory concentration (MIC) fungicidal (MFC); production proteinases phospholipase, cytotoxicity extracts. Data analyzed by ANOVA Tukey Tests (α = 5%). The results were: MIC MFC ≥ 62.5 μg/mL (C. albicans, C....
The aim of the current study was to evaluate effect chronic administration Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model depression, which induced by unpredictable (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 CUS/vehicle, CUS/fluoxetine CUS/extract mg/kg). Animals CUS group exposed a series stressors for period 21 days....
Green juice is popularly known for introducing antioxidants, improving intestinal function and reducing weight gain.In the present study we determine antioxidant effect of green comparing it with orange juice.Rats were divided into three experimental groups submitted to supplementation 15 days: (GJ) group received juice, (OJ) control water. We evaluated activity total phenolic content juices, as well rat gain. also investigated some oxidative stress parameters, namely thiobarbituric...
As a continuation of our research on the Baccharis genus, evaluation antioxidant effect by TRAP and TBARS assays three isolated compounds from n-butanol fractions B. articulata usterii is reported. The structures these were established as 4-O-beta-D-glucopyranosyl-3,5-dimethoxybenzyl-methanol (1), 5-O-[E]-dicaffeoylquinic acid (2), 7-hydroxy-5,4'-dimethoxyflavone (3). In assay it was possible to observe an both at 1.25 microg/mL. Among compounds, compound 2 displayed remarkable contribution...
Aim: This study investigated the effects of polar Butia odorata fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol.Methods: Animals were divided into 3 groups: saline, saline plus tyloxapol, B. tyloxapol. treated for 15 days with solution or after was tyloxapol.Results: Treatment reduced serum triglyceride, total cholesterol, C-reactive protein, adenosine deaminase butyrylcholinesterase activities...
In this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD Psidium cattleianum extract, Eugenia uniflora extract. increased serum interleukin-6 (IL-6) levels. On other hand, change was prevented extracts. decreased NTPDase activity lymphocytes platelets 5'-nucleotidase platelets....