A5066975491- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Women's cancer prevention and management
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Nutrition, Genetics, and Disease
- Advanced Breast Cancer Therapies
- Cancer and Skin Lesions
- Genetic factors in colorectal cancer
- Science and Education Research
- Childhood Cancer Survivors' Quality of Life
- Breast Lesions and Carcinomas
- Nosocomial Infections in ICU
- Genomic variations and chromosomal abnormalities
- Sepsis Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Multiple and Secondary Primary Cancers
- Glutathione Transferases and Polymorphisms
- Health Systems, Economic Evaluations, Quality of Life
Laboratório Bacchi
2014-2025
Eastern Cooperative Oncology Group
2023-2024
Universidade Federal do Rio Grande do Sul
2009-2023
Latin American Sepsis Institute
2021-2023
Hospital de Clínicas de Porto Alegre
2009-2018
Instituto do Câncer do Estado de São Paulo
2017-2018
AC Camargo Hospital
2017-2018
Centro de Pesquisas Oncológicas
2017-2018
Instituto Brasileiro de Controle do Câncer
2018
Pontifícia Universidade Católica do Rio Grande do Sul
2018
In Brazil, human fungal infections are prevalent, however, these conditions not officially reportable diseases. To estimate the burden of serious diseases in 1 year based on available data and published literature. Historical official from were collected Brazilian Unified Health System Informatics Department (DATASUS). For for which no available, assumptions frequencies made by estimating The incidence (/1000) hospital admissions coccidioidomycosis was 7.12; histoplasmosis, 2.19;...
Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation p.R337H is detected in 0.3% of the general population southern Brazil. This an increased risk childhood adrenal cortical carcinoma (ACC) but also common Brazilian LFS/LFL families. Breast Cancer (BC) one most diagnosed carriers. We have assessed prevalence two groups: (1) 59 BC affected women a familial history (FH) suggestive...
Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast syndromes, where specific interventions can be proposed reduce risk, has become increasingly relevant. A previous study in Southern Brazil shown that family history suggestive these syndromes may prevalent at primary care level. Development simple sensitive instrument, easily applicable units, would particularly helpful underserved communities...
BACKGROUND Pediatric cancers are a feature in patients with Li‐Fraumeni syndrome and its variant Li‐Fraumeni–like (LFS/LFL). To the best of authors' knowledge, TP53 germline mutations currently only molecular defect known to be associated this disease. Recently, specific mutation gene, p.R337H, has been reported at high prevalence Brazil. METHODS The LFS/LFL was investigated children cancer who were diagnosed tumors on spectrum small consecutive series controls without cancer. p.R337H other...
Low rates of germline genetic testing (GGT) for breast cancer (BC) have been reported globally, with limited data from low- and middle-income countries (LMICs). In this study, we used real-world to assess the GGT rate BC in an LMIC identified barriers its use. We analyzed 2,974 newly diagnosed patients AMAZONA III largest Brazilian multicenter, prospective cohort. were determined entire cohort high-risk hereditary group (HR), defined by National Comprehensive Cancer Network criteria, between...
Breast cancer (BC) is a major public health problem, with rising incidence in many regions of the globe. Although mortality has recently dropped developed countries, death rates are still increasing some developing as seen Brazil. Among reasons for this phenomenon lack structured screening programs, long waiting period between diagnosis and treatment, access to services large proportion Brazilian population. Since 2004, an intervention study cohort women Southern Brazil, denominated Porto...
Retinoblastoma (Rb) is the most common intraocular tumor diagnosed in children Brazil. However, detailed information lacking regarding patient clinical demographics. This study aimed to determine profile of patients with Rb who were treated a public university hospital southern Brazil from 1983 2012. Methods: Patients' medical records reviewed retrospectively identify principal diagnosis Rb. was classified as hereditary or non-hereditary. Clinical staging by an ophthalmologist. Statistical...
Healthcare-associated infections (HAIs) are among the most common adverse events in hospitals. We used artificial intelligence (AI) algorithms for infection surveillance a cohort study. The model correctly detected 67 out of 73 patients with HAIs. final multilayer perceptron neural network achieving an area under receiver operating curve (AUROC) 90.27%; specificity 78.86%; sensitivity 88.57%. Respiratory had best results (AUROC ≥93.47%). AI algorithm could identify is feasible method HAI...
Abstract Background: Adherence to breast cancer screening is a key element ensure effectiveness of programs aiming at downstaging cancer. In this study, we evaluated adherence program and its predictors in underserved women southern Brazil. Methods: Attendance the program, which based on yearly mammogram clinical examination, was prospectively. Mean time frames between visits were calculated. Possible (defined as mean intervals ≤18 mo), such socioeconomic indicators health/lifestyle...
Germline mutations in TP53 are the underlying defect of Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders characterized by predisposition to multiple early onset cancers. In Brazil, a variant form LFS/LFL is commonly detected because high prevalence founder mutation at codon 337 (p.R337H). The p53 protein exerts roles regulation oxidative metabolism cellular anti-oxidant defense systems. Herein, we analyzed redox parameters blood samples from...
Genetic polymorphisms in genes related to the metabolism of xenobiotics, such as glutathione S-transferases (GSTM1, GSTT1, and GSTP1) superfamily have been associated with an increased risk for breast cancer (BC). Considering high incidence BC city Porto Alegre southern Brazil, purpose this study was characterize genotypic allelic frequencies GSTM1, GSTP1, correlate these molecular findings established factors including mammographic density, a sample 750 asymptomatic women undergoing...
Abstract Background Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which caused by dominant germline mutations TP53 gene. In Brazil, a particular mutation, tetramerisation domain of gene, p.R337H, is exceedingly due to founder effect strongly associated ACC. this report, we describe phenotype long-term clinical follow-up female child diagnosed ACC homozygous for p.R337H...
The purpose of this study was to evaluate the association between apolipoprotein E (APOE) allelic frequency, serum lipoproteins and breast cancer (BC). We conducted a nested case-control within cohort including 47 cases 165 controls. Polymerase chain reaction-restriction fragment length polymorphism analyses APOE were performed. In general, participants with genotype alleles e2 e3 tended have lower triglycerides, total cholesterol low‑density lipoprotein levels higher high‑density (HDL)...
Rare germline mutations in TP53 (17p13.1) cause a highly penetrant predisposition to specific spectrum of early cancers, defining the Li-Fraumeni Syndrome (LFS). A mutation at codon 337 (p.Arg337His, c1010G>A) is found about 0.3% population Southern Brazil. This associated with partially LFS traits and patients cancers unselected for familial history. To characterize extended haplotypes carrying mutation, we have genotyped 9 short tandem repeats on chromosome 17p 12 trios Brazilian...
Abstract Background The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer atherosclerosis . Objective To investigate the relationship between anthropometric profile, dietary intake, lipid profile fasting glycemia serum levels of (adiponectin PAI-1) (ICAM-1 VCAM-1) women without undergoing routine mammographic screening. Design Transversal study. Subjects One hundred forty-five over 40-years old...
In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort) was started in Alegre, southern Brazil and within that cohort, hereditary breast cancer study initiated, aiming to determine the prevalence of phenotypes evaluate acceptance genetic risk assessment (GCRA) program. Women from who reported positive family history were referred GCRA. Of 9218 women enrolled, 1286 (13.9%) cancer. 902 attended GCRA, 55 (8%) had an estimated lifetime ³ 20% 214 (23.7%) pedigrees...