A5012717117- COVID-19 Clinical Research Studies
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- CNS Lymphoma Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Infant Development and Preterm Care
- Pancreatitis Pathology and Treatment
- Breastfeeding Practices and Influences
- CAR-T cell therapy research
- Cardiac Arrhythmias and Treatments
- Vitamin K Research Studies
- Sepsis Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Nosocomial Infections in ICU
- Healthcare during COVID-19 Pandemic
- Syphilis Diagnosis and Treatment
- Nursing Diagnosis and Documentation
- HIV/AIDS oral health manifestations
- Radiomics and Machine Learning in Medical Imaging
Hospital Alemão Oswaldo Cruz
2022-2025
Universidade de São Paulo
2014-2024
Instituto Butantan
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021-2023
Instituto do Câncer do Estado de São Paulo
2022
Instituto de Medicina Integral Professor Fernando Figueira
2022
State Laboratory
2022
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2020-2021
Abstract Background The efficacy of convalescent plasma (CP), an alternative for the treatment COVID‐19, depends on high titers neutralizing antibodies (nAbs), but assays quantifying nAbs are not widely available. Our goal was to develop a strategy predict based results anti‐SARS‐CoV‐2 immunoassays and clinical characteristics CP donors. Study Design Methods A total 214 donors were enrolled tested presence (IgG) using two commercial immunoassays: EUROIMMUN (ELISA) Abbott (Chemiluminescence)....
Previous Randomised controlled trials (RCT) evaluating chloroquine and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant difference hospitalisation rates. However, low statistical power precluded definitive answers.We conducted a multicenter, double-blind, RCT 56 Brazilian sites. Adults with suspected or confirmed presenting mild moderate symptoms ≤ 07 days prior to enrollment at least one risk factor for clinical deterioration were randomised (1:1) receive...
Vitamin K antagonists (VKA) represent an important therapeutic strategy offered by the Brazilian Unified Public Health System to patients with atrial fibrillation (AF). However, predictors of relevant clinical outcomes are understudied in real world. To determine incidence and independent valvular nonvalvular AF treated VKA. This prospective cohort included receiving VKA for ≥ 1 year. The primary were cardiovascular death, thromboembolic events, major clinically non-major bleeding,...
Abstract Background Vitamin K antagonists (VKA) represent an important therapeutic strategy offered by the Brazilian Unified Public Health System to patients with atrial fibrillation (AF). However, predictors of relevant clinical outcomes are understudied in real world. Objective To determine incidence and independent valvular nonvalvular AF treated VKA. Methods This prospective cohort included receiving VKA for ≥ 1 year. The primary were cardiovascular death, thromboembolic events, major...
COVID-19 progression is associated with an increased risk of arterial and venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the thromboembolism in hospitalised patients COVID-19, but a benefit routine anticoagulation has not been outpatient setting.We conducted randomised, open-label, controlled, multicentre study, evaluating use rivaroxaban mild or moderate patients. Adults ≥18 years old, probable confirmed SARS-CoV-2 infection, presenting within ≤7 days from...
Background: Diffuse large B-cell lymphoma (DLBCL) especially affects the older population. Old (≥60 years) and very old age (≥80 DLBCL patients often present high-risk molecular alterations, lower tolerability to conventional immunochemotherapy, poor clinical outcomes. In this scenario, attenuated therapeutic strategies, such as R-MiniCHOP of elderly regimens, have emerged for particularly fragile However, responses, outcomes, toxicities these regimens currently remain poorly understood,...
Objetivo Realizar a adaptação transcultural para língua portuguesa brasileira de dois instrumentos medida do cuidado centrado na família, um pais e outro profissionais da equipe saúde. Métodos Estudo metodológico seguindo as etapas tradução, retrotradução, análise especialistas, pré-teste, teste-reteste psicométrica após aplicação instrumento com 100 crianças hospitalizadas unidades pediátricas hospital universitário. Resultados A avaliação por especialistas ambos os apresentaram Kappa 0,85...
Nodal peripheral T-cell lymphomas [nPTCL] constitute a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena involving genes that control DNA-methylation histone deacetylation play central role in their pathogenesis. However, the mutational landscape epigenetic regulators has never been reported Latin American patients prognostic impact remains controversial.From 2000 to 2019, 59-Brazilian nPTCL were eligible for screening...
To identify the frequency of nursing diagnoses, ineffective breathing pattern, impaired gas exchange and spontaneous ventilation in newborns; and, to analyze accuracy diagnostic indicators identified for each these diagnoses.This was a cross-sectional study conducted with nonprobability sample 92 infants. Data collected were represented by demographic clinical variables, three respiratory diagnoses from NANDA International, analyzed according agreement between pairs expert nurses...
COVID-19 disease presentation is heterogeneous, from asymptomatic up to severe life-threatening forms. Getting further insights into patients with specific diseases of particular interest. We aimed identify profiles hematology hospitalized that would be associated survival and assess the differences between cohorts METHODS: A binational cohort 263 hematological was studied in Paris, France São Paulo, Brazil. Patient were based on age, comorbidities, biological measurements, symptoms...
Abstract Background Systemic amyloidosis is caused by the deposition of misfolded protein aggregates in tissues, leading to progressive organ dysfunction and death. Epidemiological studies originate predominantly from high-income countries, with few data Latin America. Due non-specific clinical manifestations, diagnosing often challenging patients experience a long journey delay diagnosis. This study aimed assess laboratory characteristics, diagnostic journey, outcomes biopsy-proven systemic...
Resumo Fundamento Estudos anteriores revelaram alto risco de eventos tromboembólicos arteriais e venosos como consequência danos virais diretos do SARS-CoV-2 em células endoteliais um meio procoagulante devido ao aumento biomarcadores o D-dímero, fibrinogênio, fator VIII. Foram realizados ensaios controlados randomizados terapias antitrombóticas pacientes internados, no entanto, poucos estudos avaliaram papel da tromboprofilaxia ambiente ambulatorial. Objetivo Avaliar se a profilaxia...
Isolated congenital atrioventricular block (CAVB) is a rare condition with multiple clinical outcomes. Ventricular remodeling can occur in approximately 10% of the patients after pacemaker (PM) implantation.To assess functional capacity children and young adults isolated CAVB chronic pacing right ventricle (RV) evaluate its correlation predictors ventricular remodeling.This cross-sectional study used cohort RV for over year. The subjects underwent echocardiographic evaluation. Functional was...
Introduction Few studies have reported the profile of patients with paroxysmal nocturnal hemoglobinuria (PNH) and their care in Brazilian health system. Objective To describe clinical epidemiological characteristics PNH public system including procedures performed, associated comorbidities visits to professionals. Methods In a real-world observational, retrospective, population-based cohort study, anonymized secondary data provided by Department Informatics Unified Health System (DATASUS)...
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, genetic profile derived from data collected in large population-based studies. Due to polygenic nature ASCVD, we aimed assess association genomics with ASCVD risk its impact occurrence acute myocardial infarction, stroke, or peripheral artery thrombotic-ischemic events at population level. CardioVascular Genes (CV-GENES) is a...