A5086979902- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Infection Control in Healthcare
- Public Health in Brazil
- Infection Control and Ventilation
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Medical Device Sterilization and Disinfection
- Pharmaceutical Practices and Patient Outcomes
- Patient Satisfaction in Healthcare
- Healthcare and Environmental Waste Management
- Central Venous Catheters and Hemodialysis
- Sepsis Diagnosis and Treatment
- COVID-19 and Mental Health
- Health, Nursing, Elderly Care
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Microscopic Colitis
- Enterobacteriaceae and Cronobacter Research
- Maternal and Neonatal Healthcare
- Pharmaceutical industry and healthcare
- Vibrio bacteria research studies
- COVID-19 Digital Contact Tracing
Hospital Alemão Oswaldo Cruz
2014-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2024
Universidade de São Paulo
2005-2023
Hospital São Paulo
2005-2023
Biology of Infection
2023
Fundação Faculdade de Medicina
2023
Universidade Brasil
2014
Increased resistance to polymyxin in Klebsiella pneumoniae (ColRKP) has been observed. Molecular epidemiology, as well the clinical impact of these difficult treat pathogens need be better characterized. We present outcomes 28 patients infected by ColRKP a tertiary hospital. Isolates with MIC >2 Vitek 2 were confirmed microdilution broth test. Polymerase chain reaction (PCR) was performed for blaKPC, blaNDM, blaOXA-48 and blamcr-1 genes isolates, Whole Genome Sequencing (WGS) six isolates....
Abstract Carbapenem-resistant Enterobacteriaceae (CRE) colonization is common in hospital patients admitted to intensive care units (ICU) from the emergency department. We evaluated effect of previous hospitalization department on CRE at ICU admission. Our case–control study included 103 cases and 201 controls; were colonized by admission controls not colonized. Risk factors stay, use carbapenem, Simplified Acute Physiology Score, upper digestive endoscopy, transfer another hospital. found...
Abstract Objective: The present study aimed to describe ICU antibiotic use based on data reported from 2009 2018 the Nosocomial Surveillance System (NSS) of State Health Department in Sao Paulo, Brazil. Design: Ecological study. Setting: Data obtained hospitals located state São Brazil 2018. Participants: Intensive care units at participant hospitals. Methods: healthcare-associated infections, usage, and bacterial identification were collected monthly by Antibiotic consumption was quantified...
Abstract Background In 2019, an estimated 1.27 million deaths were attributed to bacterial antimicrobial resistance (AR) globally. During the Coronavirus Disease 2019 (COVID-19) Pandemic, additional strain was placed on healthcare systems that may have led further increases in AR. We evaluated AR prevalence before and after onset of COVID-19 6 facilities (HCF) South America. Methods conducted ecological evaluation HCF-wide 4 private 2 public HCFs Argentina, Brazil, Chile; per country....
To describe the nationwide impact of a restrictive law on over-the-counter sales antimicrobial drugs, implemented in Brazil November 2010. Approximately 75% population receives healthcare from public health system and free-of-charge medication if prescribed. Total private pharmacies as compared with other channels oral antibiotics were evaluated this observational study before after (2008–2012). Defined daily dose per 1000 inhabitants day (DDD/TID) was used standard unit. In effect...
Background Studies on the implantation of care routines showed reduction EVD catheter-related infections rates; however zero tolerance is difficult to be achieved. The objective this study was assess impact an educational intervention maximal rates EVD-related infections. Methodology/Principal Findings quasi-experimental (before-after intervention) occurred in two phases: pre-intervention, from April 2007 July 2008, and intervention, August 2008 2010. Patients were followed for 30 days after...
Improper antibiotic use is one of the main drivers bacterial resistance to antibiotics, increasing infectious diseases morbidity and mortality raising costs healthcare. The level consumption has been shown vary according socioeconomic determinants (SED) such as income access education. In many Latin American countries, antibiotics could be easily purchased without a medical prescription in private pharmacies before enforcement restrictions on over-the-counter (OTC) sales recent years. Brazil...
COVID-19 progression is associated with an increased risk of arterial and venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the thromboembolism in hospitalised patients COVID-19, but a benefit routine anticoagulation has not been outpatient setting.We conducted randomised, open-label, controlled, multicentre study, evaluating use rivaroxaban mild or moderate patients. Adults ≥18 years old, probable confirmed SARS-CoV-2 infection, presenting within ≤7 days from...
Enterobacterales and other non-fermenting Gram-negative bacteria have become a threat worldwide owing to the frequency of multidrug resistance in these pathogens. On hand, efficacious therapeutic options are quickly diminishing. The aims this study were describe susceptibility 50 multiresistant bacteria, mostly pan-resistant, against old less-used antimicrobial drugs investigate presence genes. A total genetically distinct isolates included study, including 14 Acinetobacter baumannii...
Acinetobacter baumannii is a leading agent of healthcare-associated infection. The objective this study was to evaluate cases colonization or infection with polymyxin-resistant A. (PRAB) in liver transplant recipients and identify the risk factors for acquisition PRAB.We evaluated all patients undergoing transplantation (LT) between January November 2011. exclusion criterion death within first 72 h after transplant. Patients were screened PRAB through weekly rectal inguinal swabs during...
Abstract Background High rates of antibiotic use (AU) among inpatients with coronavirus disease 2019 (COVID-19) despite low bacterial coinfection and secondary infection have been reported. We evaluated the impact COVID-19 pandemic on AU in healthcare facilities (HCFs) South America. Methods conducted an ecologic evaluation inpatient adult acute care wards 2 HCFs each Argentina, Brazil, Chile. The for intravenous antibiotics were calculated as defined daily dose per 1000 patient-days, using...
Bacterial and aseptic meningitis after neurosurgery can present similar clinical signs symptoms. The aims of this study were to develop test a molecular method diagnose bacterial (BM) neurosurgery.A 16S ribosomal RNA gene PCR-based strategy was developed using artificially inoculated cerebrospinal fluid (CSF) followed by sequencing. tested CSF samples from 43 patients who had undergone suspected suffer meningitis, 8 without or meningitis. Patients classified into five groups, confirmed BM,...
Four cases of infection by extended spectrum beta-lactamase-producing Klebsiella pneumoniae occurred in the neonatal intensive care unit. Isolation, empiric therapy change and education produced no effect. Newborn weekly colonization rates were 0-18.7%. One health worker with onychomycosis was positive for K. pneumoniae. Isolates identical molecular typing. Outbreak controlled when excluded from