A5081240033- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Lipid Membrane Structure and Behavior
- Infections and bacterial resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Tuberculosis Research and Epidemiology
- Nanopore and Nanochannel Transport Studies
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Genetics and Biotechnology
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Free Radicals and Antioxidants
- Bacterial Identification and Susceptibility Testing
- Legionella and Acanthamoeba research
- Hematological disorders and diagnostics
- Antibiotic Use and Resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Science and Education Research
- Banana Cultivation and Research
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
Universidade do Porto
2005-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Universidade de São Paulo
2010-2021
Instituto de Medicina Avançada
2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017
Financiadora de Estudos e Projetos
2012
Fundação de Amparo à Pesquisa do Estado de São Paulo
2012
Governo do Estado de São Paulo
2012
Constructor University
2008
Rede de Química e Tecnologia
2004-2007
A blueberry extract (A) and two anthocyanin-derived extracts (B C) were prepared. The contents of polyphenols, flavonoids, anthocyanins, pigments the determined for first time. pigment profile corresponded to 15 whereas B was mainly composed anthocyanin−pyruvic acid adducts original anthocyanins C respective vinylpyranoanthocyanin−catechins (portisins). extracts' abilities inhibit lipid peroxidation, induced by 2,2'-azobis(2-methyl-propanimidamide) dihydrochloride in a liposomal membrane...
The facilitated influx of moxifloxacin through the most abundant channel in outer cell wall Gram-negative bacteria was investigated. Molecular modeling provided atomic details interaction with surface, revealed preferred orientation antibiotic along its pathway, and gave an estimated time necessary for translocation. High-resolution conductance measurements on single OmpF trimers allowed passages individual molecules to be counted. average mean residence 50 μs is agreement predicted strong...
Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important cause of nosocomial infections especially in intensive care units. This study aimed to assess clinical aspects and the genetic background CRAb among ICU patients at a Brazilian teaching hospital. 56 critically ill colonized or infected by CRAb, during stay, were prospectively assessed. Based on imipenem MIC ≥ 4 μg/mL, 28 CRAB strains screened for presence genes encoding metallo-β-lactamases OXA-type β-lactamases. The...
The aim of this study was to investigate the presence and prevalence bla(TEM), bla(SHV), bla(CTX-M) bla(GES)-like genes, responsible for extended spectrum beta-lactamases (ESBLs) production in clinical isolates Klebsiella pneumoniae collected from a Brazilian tertiary care hospital. Sixty-five ESBL producing K. isolates, between 2005 2007, were screened by polymerase chain reaction (PCR). Identification bla genes achieved sequencing. Genotyping performed enterobacterial repetitive intergenic...
Relatos mundiais têm documentado a problemática da endemicidade de isolados clínicos Pseudomonas aeruginosa multirresistente (MDR) aliada elevados índices morbidade/mortalidade. No Brasil, surtos infecção ocasionados por P. sido relacionados com uma disseminação clonal espécie. Atualmente, as opções terapêuticas para o tratamento das infecções causadas esse microrganismo são limitadas, muitas vezes restringindo-se ao uso carbapenêmicos (p. ex., imipenem [IPM]). Assim, resistência IPM é...
Purpose. Carbapenem resistance in P. aeruginosa is increasing worldwide. In Brazil, SPM-1 the main carbapenemase identified. Little known about virulence factor clones. Methodolgy. We describe a carbapenem-resistant bloodstream infection (CRPa-BSI) outbreak bone marrow transplant Unit (BMT). Twenty-nine CRPa-BSI cases were compared to 58 controls. Microbiological characteristics of isolates, such as sensitivity, gene PCR for aeruginosa, and PFGE are described, well whole-genome sequence...
Balanoposthitis is defined as the inflammation of glans penis and its foreskin. In presence other underlying medical conditions, this localized infection may spread systemically, serving a source fever bacteremia in neutropenic males. Two rare cases balanoposthitis caused by clonally related Pseudomonas aeruginosa isolate co-producing SPM-1 metallo-β-lactamase novel 16S rRNA methylase RmtD are described. Four multidrug-resistant (MDR) P. isolates were successively recovered from...
The plasmid-mediated colistin-resistance gene named mcr-1 has been recently described in different countries and it became a public health challenge. Of note, few studies have addressed the spread of Escherichia coli harboring both, community hospital settings. A total seven colistin-resistant E. carrying mcr-1, collected from 2016 to 2018, (n=4), healthcare-acquired infections (n=2) colonization (n=1) were identified three high complexity hospitals Sao Paulo, Brazil. These isolates screened...
Treatment of infections caused by A. baumannii is becoming a challenge due to the ability develop multidrug-resistance, virulence, and high mortality. We described colistin resistance virulence genes present in sixA. clinical isolates using WGS, expression qPCR, Galleria mellonella model. The colistin-resistant were assigned as ST233 colistin-susceptible ST236 ST407. contained mutations within PmrA/PmrB, pmrA showed up‐regulation all them. Only one isolate indicating G. mellonella. This...
Pseudomonas aeruginosa is an important cause of infection, especially in immunocompromised patients. In this regard, strains producing carbapenemases, mainly metallo-β-lactamases (MBLs), have become a significant public health concern. Here, we present the complete annotated genome sequence (65.7 kb) F8-related lytic myovirus (Pbunalikevirus genus) that infects MBL-producing P. strains.