A5047454761- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Enterobacteriaceae and Cronobacter Research
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Plant Pathogenic Bacteria Studies
- Aquaculture disease management and microbiota
- Antifungal resistance and susceptibility
- Genomics and Phylogenetic Studies
- Nanoparticles: synthesis and applications
- Mycobacterium research and diagnosis
- Bacterial Genetics and Biotechnology
- Photodynamic Therapy Research Studies
- Listeria monocytogenes in Food Safety
- Pneumonia and Respiratory Infections
- Identification and Quantification in Food
- Antimicrobial agents and applications
- Tuberculosis Research and Epidemiology
Universidade de São Paulo
2016-2025
Institute of Biomedical Science
2011-2024
Instituto Butantan
2006-2024
Monash University
2021
Hospital Universitário da Universidade de São Paulo
2021
Ibero American University
2020
Universidade Cidade de São Paulo
2017-2018
Centro Universitário Monte Serrat
2018
Tuskegee University
2016
Instituto de Ciências Farmacêuticas
2005
During a Brazilian multicentric antimicrobial resistance surveillance study, colistin was investigated in 4,620 Enterobacteriaceae isolated from human, animal, food and environmental samples collected 2000 to 2016. We present evidence that mcr-1-positive Escherichia coli has been emerging South America since at least 2012, supporting previous report on the possible acquisition of mcr-1-harbouring E. by European travellers visiting Latin American countries.
ABSTRACT The detection and rapid spread of colistin-resistant Enterobacteriaceae carrying the mcr-1 gene has created an urgent need to strengthen surveillance. In this study, eight clonally unrelated Escherichia coli isolates bla CTX-M or CMY-2 genes were isolated from commercial chicken meat in Brazil. Most E. strains carried IncX4 plasmids, previously identified human animal isolates. These results highlight a new reservoir -harboring South America.
A colistin-resistant Escherichia coli strain was recovered from a patient with diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. isolate belonged to widespread sequence type (ST) 101 and harbored mcr-1 gene on an IncX4 plasmid highly similar mcr-1-bearing plasmids were recently identified Enterobacteriaceae food, animal, human samples different continents. These results suggest self-transmissible IncX4-type may represent promiscuous contributing intercontinental...
The emergence and rapid spread of colistin-resistant Escherichia coli carrying the mcr-1 gene have generated an urgent need to strengthen surveillance. We performed a meticulous investigation strains this sort, which resulted in identification international clones E. IncX4-plasmid-mediated blaCTX-M genes recreational waters public urban beaches cities with high tourist turnover, highlighting new environmental reservoir.
Abstract Multidrug-resistant (MDR) Salmonella enterica has been deemed a high-priority pathogen by the World Health Organization. Two hundred and sixty-four isolates recovered over 16-year period (2000 to 2016) from poultry swine production chains, in Brazil, were investigated whole-genome sequencing (WGS). Most international lineages belonging 28 serovars, including, S . serovars Schwarzengrund ST96, Typhimurium ST19, Minnesota ST548, Infantis ST32, Heidelberg ST15, Newport ST45,...
A One Health approach for antimicrobial resistance must integrate whole-genome sequencing surveillance data of critical priority pathogens from human, animal and environmental sources to track hot spots routes transmission developing effective prevention control strategies. As part the Grand Challenges Explorations: New Approaches Characterize Global Burden Antimicrobial Resistance Program, we present genomic WHO carbapenemase-resistant, ESBL-producing, and/or colistin-resistant Escherichia...
Antimicrobial blue light (aBL) offers efficacy and safety in treating infections. However, the bacterial targets for aBL are still poorly understood may be dependent on species. Here, we investigated biological of killing by (λ = 410 nm) three pathogens: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. Initially, evaluated kinetics bacteria exposed to used this information calculate lethal doses (LD) responsible 90 99.9% bacteria. We also quantified endogenous porphyrins...
The advantage of using plants in nanoparticles synthesis is that they are easily available, safe to handle and possess a broad variability metabolites such as antioxidants, nucleotides vitamins. aim this study was investigate the effects Green Zimbro tea also coconut water reducing stabilizer agent gold nanoparticle synthesis. were characterized by UV-Vis absorption spectroscopy, X-ray diffraction (XRD), Dynamic light scattering (DLS) Transmission electron microscopy (TEM) analysis. Their...
The interactions between three different protein antigens and dioctadecyldimethylammonium bromide (DODAB) dispersed in aqueous solutions from probe sonication or adsorbed as one bilayer onto particles was comparatively investigated. model proteins were bovine serum albumin (BSA), purified 18 kDa/14 kDa Taenia crassiceps (18/14-Tcra) a recombinant, heat-shock hsp-18 Mycobacterium leprae. Protein-DODAB complexes water solution characterized by dynamic light scattering for sizing zeta-potential...
Carbapenem resistance among Acinetobacter baumannii strains isolated from clinical settings in Brazil has increased dramatically the last 10 years due to emergence and dissemination of OXA-type carbapenemase encoding genes. This study aimed characterize presence carbapenem-hydrolyzing class D β-lactamases (CHDL)-encoding genes clonal complexes playing a major role OXA-carbapenemase-producing A. Southeast Brazil. A total 74 patients admitted 4 hospitals were analyzed. Molecular...
The emergence and rapid dissemination of colistin-resistant Escherichia coli carrying the plasmid-mediated mcr-1 gene have created an urgent need to develop specific screening methods. In this study, we evaluated four assays based on inhibition MCR-1 activity by EDTA: (i) a combined-disk test (CDT) comparing zones colistin (10 μg) plus EDTA (100 mM); (ii) reduction MIC (CMR) in presence (80 μg/ml); (iii) modified polymyxin Nordmann/Poirel (MPNP); (iv) alteration zeta potential (RZP =...