A5082676408- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Neutropenia and Cancer Infections
- Diagnosis and treatment of tuberculosis
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- COVID-19 and healthcare impacts
- Toxoplasma gondii Research Studies
- Nail Diseases and Treatments
- Parvovirus B19 Infection Studies
- Plant Pathogens and Fungal Diseases
- Cystic Fibrosis Research Advances
- Acute Lymphoblastic Leukemia research
- Mycotoxins in Agriculture and Food
AC Camargo Hospital
2019-2025
European Society of Clinical Microbiology and Infectious Diseases
2024-2025
Universidade de São Paulo
2011-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011-2023
Fundação Pró-Sangue Hemocentro de São Paulo
2023
Vall d'Hebron Hospital Universitari
2020
The University of Texas MD Anderson Cancer Center
2018-2019
Michael E. DeBakey VA Medical Center
2019
University of Maryland, Baltimore
2019
U-M Rogel Cancer Center
2019
Summary Objective To evaluate the frequency and clinical features of endemic other opportunistic infections in liver or kidney transplant recipients four centres different geographical areas Brazil. Methods Retrospective analysis medical laboratory records on recipients. Analyses were performed with spss statistical software. Results From 2001 to 2006, 1046 708 transplants registered all centres. The average age was 42 years. Among 82 (4.7%) cases infections, most frequent tuberculosis...
Hematological malignancy (HM) patients treated with anti-CD20 monoclonal antibodies are at higher risk for severe COVID-19. A previous single-center study showed worse outcomes in obinutuzumab compared to rituximab. We examined this hypothesis a large international multicenter cohort.
Abstract Background Respiratory viral infection (RVI) is a significant complication in patients with hematologic malignancies (HM). While risk factors and outcomes of severe infections have been studied allogeneic hematopoietic cell transplant (HCT) recipients, data limited for lymphoma multiple myeloma (MM). We investigated the associated respiratory syncytial virus (RSV) or influenza (IFV) from large cohort MM.Figure 1:Respiratory per quarter stratified by pathogen.The dashed line...
Abstract Background Respiratory viral infections (RVIs) pose a significant clinical challenge in immunocompromised hosts, including patients with leukemia and hematopoietic cell transplant (HCT) recipients. Despite advances infection prevention, diagnostics, management, RVIs continue to be major cause of morbidity mortality this patient population, due progression lower respiratory tract (LRTI). We aimed identify risk factors associated LRTI HCT recipients.Table 1:Baseline characteristics...
Abstract Chimeric antigen receptor (CAR) T cell therapy is increasingly being adopted as a clinical modality for patients with relapsed/refractory hematological malignancies. Despite the efficacy of CAR-T therapy, considerable fraction still relapses during first months following infusion. The limited efficiency thought to relate epigenetic mechanisms involved in suppression and dysfunction. Here, screening multiple inhibitors revealed that targeting PRC2 consistently induced development...
Abstract Background Respiratory viral infection (RVI) is a significant complication in patients with hematologic malignancies. While risk factors of lower respiratory tract infections (LRIs) and mortality have been studied allogeneic hematopoietic cell transplant recipients, data remain limited for lymphoma multiple myeloma (MM). We investigated outcomes LRI secondary to syncytial virus (RSV) or influenza (IFV) these populations. Methods performed retrospective study adults MM RSV IFV RVIs...
The objective of this study was to analyze the incidence and risk factors for healthcare-associated infections (HAI) among hematopoietic stem cell transplantation (HSCT) patients, impact such on mortality during hospitalization.We conducted a 9-year (2001-2009) retrospective cohort including patients submitted HSCT at reference center in São Paulo, Brazil. HAI calculated using days neutropenia as denominator. Data were analyzed EpiInfo 3.5.1.Over period there 429 neutropenic with total 6816...
Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among immunocompromised patients with underlying malignancies prior transplants. FDA approved Isavuconazole as primary therapy for Aspergillosis (IA) Mucormycosis. This study aims to compare the real-world clinical outcomes safety isavuconazole voriconazole an amphotericin B-based regimen in transplant. In addition, response anti-fungal outcome were compared disparity (elderly, obese patients, renal insufficiency...
The Practice Guidelines Committee of the American Society Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A new approach was adopted better serve clinical providers by publishing each standalone topic in series a concise format frequently asked questions (FAQ), tables, figures. Experts HCT diseases...
Multiple myeloma (MM) associated with Chagas disease is rarely described. This and its therapy suppress T cell macrophage functions increase regulatory function, allowing the of parasitemia risk Disease Reactivation (CDR). We aimed to analyze role conventional (cPCR) quantitative Polymerase Chain Reaction (qPCR) for prospective monitoring T. cruzi parasitemia, searching markers preemptive antiparasitic in MM patients disease. Moreover, we investigated incidence management hematological...
We describe the rate of incidence Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient days neutropenia risk factors associated with severe form disease death. The ELISA method (Ridascreen-Biopharm, Germany) for detections toxins A/B was used identify C. difficile. A multivariate analysis performed evaluate potential CDAD death within 14 after...
Cytomegalovirus (CMV) infection remains a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). We conducted retrospective study to determine the clinical and economic burden of pre-emptive therapy (PET) for CMV in 100 consecutive hospitalized adult positive serostatus allo-HCT recipients compared their hospitalization cost with graft vs host disease without (control group) across 19 US cancer centers patients between 2012 2015 (Vizient database). A total 192...
Invasive aspergillosis is a life-threatening lung or systemic infection caused by the opportunistic mold Aspergillus fumigatus. The disease affects mainly immunocompromised hosts, and patients with hematological malignances who have been submitted to stem cell transplantation are at high risk. Despite current use of Platelia™ as diagnostic test, early diagnosis invasive remains major challenge in improving prognosis disease. In this study, we used an immunoproteomic approach identify...
Purpose. Carbapenem resistance in P. aeruginosa is increasing worldwide. In Brazil, SPM-1 the main carbapenemase identified. Little known about virulence factor clones. Methodolgy. We describe a carbapenem-resistant bloodstream infection (CRPa-BSI) outbreak bone marrow transplant Unit (BMT). Twenty-nine CRPa-BSI cases were compared to 58 controls. Microbiological characteristics of isolates, such as sensitivity, gene PCR for aeruginosa, and PFGE are described, well whole-genome sequence...
Refractory or resistant cytomegalovirus (CMV) infections are challenging complications after hematopoietic cell transplantation (HCT). Most refractory CMV associated with poor outcomes and increased mortality. Prompt recognition of infections, understanding the resistance pathways, treatment options in HCT recipients imperative.New definitions for have been introduced future clinical trials. Interestingly, more commonly encountered when compared infections. terminase complex mutations UL56,...
Abstract Background Respiratory syncytial virus ( RSV ) is a common cause of seasonal respiratory viral infection in hematopoietic stem cell transplantations HSCT patients. The efficacy treatment, however, remains controversial. We describe an outbreak 31 cases that occurred outpatient care unit the fall season from M arch through ay 2010, with good outcome without any specific antiviral treatment. Methods During these 3 months, 222 nasal wash samples were tested and, these, outpatients...
Morbidity and mortality from Mycobacterium tuberculosis (Mtb) infection remain significant in cancer patients. We evaluated clinical characteristics, management, outcomes patients with active Mtb at our institution who had or suspicion of cancer.We retrospectively examined medical records all laboratory-confirmed diagnosed between 2006 2014.A total 52 were identified during the study period, resulting an average rate 6 new cases per year. Thirty-two (62%) underlying cancer, while 20 (38%)...