A5016005877- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Infection Control and Ventilation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and healthcare impacts
- Infective Endocarditis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Respiratory viral infections research
- Noise Effects and Management
- Phonocardiography and Auscultation Techniques
- Breast Lesions and Carcinomas
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Fungal Infections and Studies
- HIV-related health complications and treatments
- Pneumonia and Respiratory Infections
- Cancer Immunotherapy and Biomarkers
Hadassah Medical Center
2018-2025
Hebrew University of Jerusalem
2020-2025
University Medical Center
2022-2025
Hebrew College
2022
<h3>Importance</h3> Despite the high 3-dose vaccination rate among health care workers (HCWs) in Israel, a of SARS-CoV-2 breakthrough infections this group was observed during Omicron wave. As result, Israeli Ministry Health decided to recommend fourth vaccine dose medical staff. <h3>Objective</h3> To evaluate benefit BNT162b2 on infection HCWs. <h3>Design, Setting, and Participants</h3> This multicenter cohort study performed January 2022, first month 4-dose campaign, surge variant All at...
The use of bacteriophages (phages) is reemerging as a potential treatment option for antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses that may serve personalized therapeutic with minimal collateral damage to the patient microbiome. In 2018 we established Israeli Phage Therapy Center (IPTC) shared initiative Hadassah Medical and Hebrew University Jerusalem, aiming conduct all steps required phage-based solutions, from phage isolation...
Hematological malignancy (HM) patients treated with anti-CD20 monoclonal antibodies are at higher risk for severe COVID-19. A previous single-center study showed worse outcomes in obinutuzumab compared to rituximab. We examined this hypothesis a large international multicenter cohort.
Carbapenemase-producing Enterobacterales (CPE) pose a major healthcare challenge. We report the first hospital outbreak of Pseudocitrobacter faecalis carrying blaNDM-1 using an omics-based approach. Short- and long-read sequencing enabled genomic epidemiological investigation to track its spread, characterize resistome, analyze context blaNDM-1. Additionally, we developed implemented MALDI-TOF MS-based method for rapid isolate typing protein biomarkers. Our identified two independent...
Background: Mycoplasma pneumoniae (MP) is a major cause of community-acquired upper and lower respiratory infections in school-age children; however, there increasing recognition that younger children are also affected. Clinical manifestations vary from asymptomatic, to severe complicated pneumonia sometimes with extrapulmonary manifestations. Methods: We reviewed the medical records all MP positive pediatric patients admitted Hadassah-Hebrew University Medical Center. case was defined if...
Abstract Background Little is known about the risk of progression from carbapenemase-producing Enterobacterales (CPE) carriage to CPE bloodstream infection (BSI) outside high-risk settings. We aimed determine incidence BSI among carriers and assess whether differs by carbapenemase, species, setting. Methods conducted a nationwide population-based retrospective cohort study using national databases. The consisted all patients in Israel with detected screening 1 January 2020 10 October 2022....
Among SARS-CoV-2-infected mothers, vaginal delivery rates were high and associated with favorable outcomes no cases of neonatal COVID-19. To investigate the mode its impact on immediate outcome in women. A prospective study following pregnant women diagnosed COVID-19 who delivered between March 15th July 4th seven university affiliated hospitals Israel. total 52 a confirmed diagnosis participating centers during period. The median gestational age at time was 38 weeks, 16 (30.8%) complicated...
In the recent year, rapidly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed major challenges on public health systems.1World Health OrganizationWHO Director-General's opening remarks at Mission briefing COVID-19—16 April 2020. 2020.https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-mission-briefing-on-covid-19---16-april-2020Date accessed: December 31, 2020Google Scholar Timely detection of cases is...
previous worldwide reports indicated a substantial short-term reduction in various respiratory infections during the early phase of SARS-CoV-2 pandemic.exploring long-term impact COVID-19 pandemic on pathogens.retrospective analysis bacterial and viral positivity rate samples, between 1 January 2017-30 June 2022 tertiary hospital Jerusalem, Israel.A decline overall tests was observed first months pandemic. Respiratory isolations Hemophilus influenza Streptococcus pneumoniae were...
Diabetes mellitus (DM) is more common among people living with human immunodeficiency virus (PLWH) compared healthy individuals. In a prospective multicenter study (N = 248), we identified normoglycemic (48.7%), prediabetic (44.4%), and diabetic (6.9%) PLWH. Glycosylated hemoglobin (HbA1c) fasting blood glucose (FBG) sensitivity in defining dysglycemia was 96.8%, while addition of oral tolerance test led to reclassification only 4 patients. Inclusion 93 additional PLWH known DM enabled...