A5087514590- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Macrophage Migration Inhibitory Factor
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Pregnancy and preeclampsia studies
- Immune responses and vaccinations
- PI3K/AKT/mTOR signaling in cancer
- Virology and Viral Diseases
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Cell death mechanisms and regulation
- Parvovirus B19 Infection Studies
Hadassah Medical Center
2008-2024
Hebrew University of Jerusalem
2020-2021
Riga Stradiņš University
2008
Technion – Israel Institute of Technology
1989
Pooling multiple swab samples before RNA extraction and real-time reverse transcription polymerase chain reaction (RT-PCR) analysis has been proposed as a strategy to reduce costs increase throughput of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests. However, reports on practical large-scale group testing for SARS-CoV-2 have scant. Key open questions concern reduced sensitivity due sample dilution, the rate false positives, actual efficiency (number tests saved by...
Abstract Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to neurodevelopmental disabilities. Universal newborn infant screening of cCMV has been increasingly advocated. In absence a high-throughput test, which can identify all infected infants, development an accurate and efficient testing strategy remained ongoing challenge. Here we assessed implementation pooled saliva polymerase chain reaction (PCR) tests for universal cCMV, in two hospitals Jerusalem...
The H19-derived microRNA-675 (miR-675) has been implicated as both tumor promoter and suppressor also plays a role in liver inflammation. We found that miR-675 promotes cell death human hepatocellular carcinoma (HCC) lines. show Fas-associated protein with domain (FADD), mediator of apoptotic signaling, is downregulated by negative correlation exists between FADD expression mouse models HCC (p = 0.014) well samples 0.017). demonstrate model inflammation overexpression necroptosis, which can...
The tumor suppressor p53 is a central regulator of signaling pathways that controls the cell cycle and maintains integrity human genome. level regulated by mouse double minute 2 homolog (Mdm2), which marks for proteasomal degradation. p53‐Mdm2 circuitry subjected to complex regulation variety mechanisms, including microRNAs (miRNAs). We found novel effector this regulatory circuit, namely, miR‐122*, passenger strand abundantly expressed liver‐specific miR‐122. Here, we demonstrate miR‐122*...
Abstract Pooling multiple swab samples prior to RNA extraction and RT-PCR analysis was proposed as a strategy reduce costs increase throughput of SARS-CoV-2 tests. However, reports on practical large-scale group testing for have been scant. Key open questions concern reduced sensitivity due sample dilution; the rate false positives; actual efficiency (number tests saved by pooling) impact infection in population assay performance. Here we report 133,816 collected at April-September 2020,...
Nodding syndrome (NS) is a devastating and enigmatic childhood epilepsy. NS accompanied by multiple neurological impairments neuroinflammation, associated with the parasite Onchocerca volvulus (Ov) other environmental factors. Moreover, seems to be an 'Autoimmune Epilepsy' since: 1. ~50% of patients have neurotoxic cross-reactive Ov/Leimodin-I autoimmune antibodies. 2. Our recently published findings: Most (~86%) glutamate-receptor AMPA-GluR3B peptide antibodies that bind, induce Reactive...
previous worldwide reports indicated a substantial short-term reduction in various respiratory infections during the early phase of SARS-CoV-2 pandemic.exploring long-term impact COVID-19 pandemic on pathogens.retrospective analysis bacterial and viral positivity rate samples, between 1 January 2017-30 June 2022 tertiary hospital Jerusalem, Israel.A decline overall tests was observed first months pandemic. Respiratory isolations Hemophilus influenza Streptococcus pneumoniae were...
The gastrointestinal (GI) tract is a major human adenovirus (HAdV) replication site in patients undergoing hematopoietic stem cell transplantation (HSCT), yet the prevalence and correlates of HAdV GI infection this setting have remained poorly recognized, especially among adult HSCT recipients.We retrospectively studied risk factors GI-tissue recipients (73 adults 15 children) with symptoms who underwent biopsy between January-2012 December-2017. presence tissues was determined by real-time...
Background & aims Acute hepatitis C (AHC) is not frequently identified because patients are usually asymptomatic, although may be recognized after iatrogenic exposures such as needle stick injuries, medical injection, and acupuncture. We describe an outbreak of AHC among 12 who received IV saline flush from a single multi-dose vial intravenous contrast administration for computerized tomography (CT) scan. The last patient to receive with at the clinic on previous day was known have chronic...
BACKGROUND & AIMS Acute hepatitis C (AHC) is not frequently identified because patients are usually asymptomatic, although may be recognized after iatrogenic exposures such as needle stick injuries, medical injection, and acupuncture. We describe an outbreak of AHC among 12 who received IV saline flush from a single multi-dose vial intravenous contrast administration for computerized tomography (CT) scan. The last patient to receive with at the clinic on previous day was known have chronic...
Nodding syndrome (NS) is a catastrophic and enigmatic childhood epilepsy, accompanied by multiple neurological impairments neuroinflammation. Of all the infectious, environmental psychological factors associated with NS, major culprit Onchocerca Volvulus (Ov)–a parasitic worm transmitted to human blackflies. NS seems be an ’Autoimmune Epilepsy’ in light of recent findings deleterious autoimmune antibodies Glutamate receptors Leiomodin-I patients. Moreover, we recently found immunogenetic...
Abstract A solid phase, enzyme‐linked immunosorbent assay (ELISA) competition kit was developed to detect circulating native ras gene‐related products in sera of 151 healthy volunteers and cancer patients. This uses monoclonal antibody (mAb) BST‐6A generated against a yeast‐derived, ras‐related polypeptide Yp20. Only 2% (1 58) normal control showed strong competition, as compared 15% (5 34) patients with early stage or no evidence disease, 44% (26 59) advanced disease. These differences were...