Batel Shalom
A5025216912- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
Hebrew University of Jerusalem
2018-2023
Hadassah Medical Center
2020-2021
Pooling multiple swab samples before RNA extraction and real-time reverse transcription polymerase chain reaction (RT-PCR) analysis has been proposed as a strategy to reduce costs increase throughput of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests. However, reports on practical large-scale group testing for SARS-CoV-2 have scant. Key open questions concern reduced sensitivity due sample dilution, the rate false positives, actual efficiency (number tests saved by...
Abstract Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of multiple tumor types known to enhance oncogenicity, yet whether or not bona fide oncogene still matter debate. Although mutations were recently identified human cancers various origins, functional activities these mutants are known. We tested transforming potential three lung adenocarcinoma: E59K, D517E, and L801P. Results from several assays indicative such...
To explore the contribution of Vav1, a hematopoietic signal transducer, to pancreatic ductal adenocarcinoma (PDAC) development, we generated transgenic mouse lines expressing, K-Ras G12D , or both and Vav1 in acinar cells. Co-expression synergistically enhanced acinar-to-ductal metaplasia (ADM) formation, far exceeding number lesions developed mice. Mice expressing only did not develop ADM. Moreover, incidence PDAC /Vav1 was significantly higher than Discontinuing expression mice elicited...
Vav1 is normally and exclusively expressed in the hematopoietic system where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), firmly regulated by tyrosine phosphorylation. Mutations overexpression of malignancies, human cancers various histologic origins, are well documented. To reveal whether different tissues suffices for promoting development malignant lesions, we transgenic mice using ubiquitous ROSA26 promoter (Rosa Vav1). We detected expression epithelial organs...
Introduction The activity of Vav1 as a mutant oncogene in human tumours has remained questionable for decades. Although mutants were recently identified cancers various origins, the functional these is not fully studied. physiologically active GDP/GTP nucleotide exchange factor (GEF) hematopoietic system. In this study, we addressed contribution several cancer-identified to tumorigenic processes. Material and methods We introduced amino-acid substitutions at residues lung cancer follows:...