A5054249760- Bone fractures and treatments
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Spinal Fractures and Fixation Techniques
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Bone health and osteoporosis research
- Hip disorders and treatments
- Mesenchymal stem cell research
- Cardiac, Anesthesia and Surgical Outcomes
- Elbow and Forearm Trauma Treatment
- Traumatic Ocular and Foreign Body Injuries
- Spine and Intervertebral Disc Pathology
- Trauma and Emergency Care Studies
- Shoulder Injury and Treatment
- Disaster Response and Management
- Knee injuries and reconstruction techniques
- Trauma Management and Diagnosis
- Foot and Ankle Surgery
- Shoulder and Clavicle Injuries
- Abdominal Trauma and Injuries
- Bone and Joint Diseases
- Advanced X-ray and CT Imaging
Hadassah Academic College
2006-2024
Hadassah Medical Center
2015-2024
Hebrew University of Jerusalem
2008-2023
Agruicultural Research Institute
2021
Jerusalem College of Technology
2019
University Hospitals Birmingham NHS Foundation Trust
2017
Laboratoire National de Santé
2017
Biology of Infection
2017
Engineering Associates (United States)
2017
Ontario Institute for Cancer Research
2017
The culture expansion of human mesenchymal stem cells (hMSCs) may alter their characteristics and is a costly time-consuming stage. This study demonstrates for the first time that immunoisolated noncultured CD105-positive (CD105(+)) hMSCs are multipotent in vitro exhibit capacity to form bone vivo. recognized as promising tools regeneration. However, stage limiting step clinical setting. To establish simple, efficient, fast method applying these formation, distinct population CD105(+) was...
Bisphosphonates (BPs) evolved as the mainstay for treatment of osteoporosis, reducing incidence fractures. Recently several publications described occurrence low-energy subtrochanteric and femoral shaft fractures associated with long-term BP use. The aim this study was to describe outcome surgically treated femur prolonged use.Fifteen patients suffering from 17 atypical fragility (>3 years) use were located. Data included fracture type, time use, last bone mineral density DEXA scores neck...
Background: The quality of reduction the syndesmosis is an important factor in outcome ankle fractures associated with a syndesmotic injury. purpose this study was to directly compare accuracy reductions obtained using intraoperative standard fluoroscopic techniques against three-dimensional imaging Iso-C3D fluoroscope. Methods: We prospectively reviewed studies patients who were diagnosed as having preoperative or evidence diastasis (on basis Cotton test and/or manual external rotation...
Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy early minimally invasive intervention (MII) in treatment these fractures. A total 24 consecutive patients who underwent operative for distal were randomized into a control an group. MII entailed aspirating iliac crest bone marrow peripheral blood, yielding mesenchymal stem cells (MSCs) platelet-rich plasma (PRP) respectively, that mixed with demineralized matrix (DBM)...
Abstract Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps ancient present-day humans, as well six chimpanzees, detect differentially methylated regions likely emerged modern humans after the split from Neanderthals Denisovans. We show genes associated with face vocal tract...
The use of bacteriophages (phages) is reemerging as a potential treatment option for antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses that may serve personalized therapeutic with minimal collateral damage to the patient microbiome. In 2018 we established Israeli Phage Therapy Center (IPTC) shared initiative Hadassah Medical and Hebrew University Jerusalem, aiming conduct all steps required phage-based solutions, from phage isolation...
Background Perioperative myocardial ischemia occurs in 35% of unselected elderly patients undergoing hip fracture surgery. epidural analgesia may reduce the incidence adverse cardiac events. Methods The effect early administration during stressful period, on events was evaluated a prospective randomized study 68 with fractures who either had known coronary artery disease or were at high risk for disease. On admission to emergency room, assigned receive usual care analgesic regimen...
There are several gene therapy approaches to tissue regeneration. Although usually efficient, virusbased may elicit an immune response against the viral proteins. An alternative approach, nonviral transfer, is safer, and can be controlled reproduced. We hypothesized that in vivo bone formation could achieved using human mesenchymal stem cells (hMSCs) nonvirally transfected with morphogenetic protein–2 (hBMP-2) or –9 (hBMP-9) gene. Human MSCs were nucleofection, a unique...
Sixty patients with acetabular fractures were treated surgically. All a result of high energy trauma, most significant associated injuries. Fifty-three the followed up for at least 2 years. Clinical outcome was analyzed clinically using Harris hip score and radiographically. In 41 (77.4%) patients, surgical procedure judged successful (Harris greater than 80 points). Three factors found to be statistically predictors such an outcome: patient age younger 40 years; simple based on...
Assessing femoral neck shortening (FNS) and varus collapse after internal fixation of fractures using computerized navigation (CN).Retrospective cohort study.Academic Level I trauma center.Forty-one patients who had healed treated with CN between the years 2003 2008. Average age was 65 (range, 14-91 years). Thirty-six nondisplaced five displaced fractures.Screws were placed in an inverted triangle formation Follow-up films digitized into a PACS system, calibrated, analyzed CAD software.The...
Changes in the content of aggrecan, an essential proteoglycan articular cartilage, have been implicated pathophysiology osteoarthritis (OA), a prevalent age-related, degenerative joint disease. Here, we examined effect SOX9 acetylation on ACAN transactivation context osteoarthritis. Primary chondrocytes freshly isolated from degenerated OA cartilage displayed lower levels mRNA and higher acetylated compared with cells intact regions cartilage. Degenerated presented chondrocyte clusters...
Background Instrumented spinal fusion surgery is increasingly performed. Breaching of the pedicle occurs in 3–55% screws; clinically significant screw misplacements occur 0–7% all transpedicular placements. Several techniques have reduced this incidence but none gained popularity due to cost as well staff issues. Surgical robots offer distinct added value accuracy and minimal invasiveness. The aim study introduce SpineAssist® - a novel spine miniature robot, discuss various reasons that had...
The authors hypothesized that spinal fusion can be achieved and monitored by using cell-mediated gene therapy. Mesenchymal stem cells (MSCs) genetically engineered to express recombinant human bone morphogenetic protein-2 (rhBMP-2) conditionally, were implanted into the paraspinal muscles of mice establish fusion. goal was demonstrate an MSC-based therapy platform in which controlled expression is used obtain a murine model.Mesenchymal expressing rhBMP-2 injected paravertebral muscle mice....
The purpose of this study was to analyze the vascular complications 24 children with supracondylar humeral fractures treated in two affiliated hospitals and propose a management plan. Exploration repair brachial artery were undertaken 11 cases which pulse did not resume following reduction fracture. repaired vessels found be patent on follow-up. Angiography performed six resulted improved comparison no angiography performed. We believe that intra-operative are indicated most palpable does...
To determine the effectiveness of closed, intramedullary exchange nailing with reamed insertion for treatment femoral shaft nonunions previously treated an nail.Retrospective cohort study.Academic level I trauma center.Forty-two patients whose fracture was initially managed nail, were subsequently by their nonunion in our center. Seven had infected as proved intraoperative cultures.Closed, a larger diameter nail.Radiographic and clinical evidence healing.Thirty-six (86%) heal without further...
Sirtuin 1 (SirT1) has been implicated in the regulation of human cartilage homeostasis and chondrocyte survival. Exposing osteoarthritic (OA) chondrocytes to tumor necrosis factor α (TNFα) generates a stable enzymatically inactive 75-kd form SirT1 (75SirT1) via cathepsin B-mediated cleavage. Because 75SirT1 is resistant further degradation, we hypothesized that it distinct role OA, present study was undertaken identify this role.The presence B 75SirT OA normal analyzed. Confocal imaging used...
In Brief Study Design. Retrospective. Objective. To assess radiation exposure time during robot-guided vertebral body augmentation compared with other published findings. Summary of Background Data. Rising incidence compression fractures in the aging population result widespread use cement significant to surgeon, operating room staff, and patient. Radiation leads higher cancer rates among orthopedic spine surgeons patients. Methods. Thirty-three patients 60 underwent performed by 2...
ABSTRACT Type II collagen is a key cartilaginous extracellular protein required for normal endochondral development and cartilage homeostasis. COL2A1 gene expression positively regulated by the NAD-dependent deacetylase Sirtuin 1 (SirT1), through its ability to bind chromatin regions of promoter enhancer. Although SirT1/Sox9 binding on enhancer site was previously demonstrated, little known about functional role site. Here, we examined mechanism which promoter-associated SirT1 governs...