A5083668720- Language and cultural evolution
- Animal Vocal Communication and Behavior
- Forensic and Genetic Research
- RNA Research and Splicing
- Genetic and phenotypic traits in livestock
- Genomics and Chromatin Dynamics
- Folklore, Mythology, and Literature Studies
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Genome Rearrangement Algorithms
- Land Rights and Reforms
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Algorithms and Data Compression
- Genomics and Phylogenetic Studies
- Genetic Syndromes and Imprinting
- RNA regulation and disease
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cleft Lip and Palate Research
- Yersinia bacterium, plague, ectoparasites research
Stanford University
2023-2024
Hebrew University of Jerusalem
2013-2021
Institute of Life Sciences
2017
Technion – Israel Institute of Technology
2016
Weizmann Institute of Science
2014
Tel Aviv University
2014
Significance C/D box small nucleolar RNAs (SNORDs) are abundant, short, nucleoli-residing, noncoding that guide the methyltransferase fibrillarin to perform 2′- O -methylation of target RNAs. We identified 29 SNORDs present in a fibrillarin-containing fraction as well fibrillarin-free enriched spliceosomes. One these SNORDs, SNORD27 , directs rRNA methylation and regulates alternative pre-mRNA splicing (AS) E2F7 pre-mRNA, transcriptional repressor cell cycle-regulated genes. likely AS by...
Abstract Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps ancient present-day humans, as well six chimpanzees, detect differentially methylated regions likely emerged modern humans after the split from Neanderthals Denisovans. We show genes associated with face vocal tract...
Abstract MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction them encoded in introns RNA polymerase II transcripts. Thus, the biogenesis intronic miRNAs by microprocessor splicing their host spliceosome require coordination between these processing events. This cross-talk is addressed here. We show that key proteins Drosha DGCR8 as well pre-miRNAs cosediment with supraspliceosomes, where nuclear posttranscriptional executed. further inhibition increases whereas...
A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) converted to inosine (I) by deaminases (ADARs) double-stranded regions, mainly noncoding. Mutations ADAR enzymes Caenorhabditis elegans cause defects normal development but are not lethal as human and mouse. Previous studies C. indicated competition between interference (RNAi) mechanisms, based on the observation that worms lack both mechanisms do exhibit defects, contrast developmental observed when only absent....
Abstract In a genetically admixed population, individuals possess genealogical and genetic ancestry from multiple source groups. Under mechanistic model of admixture, we study the number distinct ancestors populations that admixture represents. Combining with recombination describes probability ancestor is ancestor, for member count populations—those who contribute to genome modern individual. We compare patterns in numbers across generations. To illustrate enumeration an group, apply...
The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled that is exclusively expressed in neurons. Here, we report the 5' untranslated region of pre-mRNA as well its hosted miRNAs widely non-neuronal cell lines. Alternative splicing HTR2C regulated by MBII-52. MBII-52 and neighboring MBII-85 cluster are absent people with Prader-Willi syndrome, which likely causes disease. We show increase expression UTR influence miRNAs. data indicate transcriptional unit expressing more complex...
Abstract Members of genetically admixed populations possess ancestry from multiple source groups, and studies human genetic admixture frequently estimate components corresponding to fractions individual genomes that trace specific ancestral populations. However, the same numerical fraction can represent a wide array scenarios within an individual’s genealogy. Using mechanistic model admixture, we consider genealogically: how many ancestors does represent? We African-Americans, for whom...
Summary Regulatory changes are broadly accepted as key drivers of phenotypic divergence. However, identifying regulatory that underlie human-specific traits has proven very challenging. Here, we use 63 DNA methylation maps ancient and present-day humans, well six chimpanzees, to detect differentially methylated regions emerged in modern humans after the split from Neanderthals Denisovans. We show genes affecting face vocal tract went through particularly extensive changes. Specifically,...
Abstract Rooted binary galled trees generalize rooted to allow a restricted class of cycles, known as galls . We build upon the Wedderburn-Etherington enumeration unlabeled with n leaves enumerate leaves, also enumerating and g galls, $$0 \leqslant \lfloor \frac{n-1}{2} \rfloor $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>0</mml:mn> <mml:mo>⩽</mml:mo> <mml:mi>g</mml:mi> <mml:mo>⌊</mml:mo> <mml:mfrac> <mml:mi>n</mml:mi> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn>...
Abstract Motivation The rise in the number of genotyped ancient individuals provides an opportunity to estimate population admixture models for many populations. However, describing modern populations as mixtures ones, it is typically difficult model mixing coefficients and evaluate its fit data. Results We present LINADMIX, designed tackle this problem by solving a constrained linear when both genotypes are represented low-dimensional space. LINADMIX estimates their standard errors,...
In genetically admixed populations, individuals possess ancestry from multiple source groups. Studies of human genetic admixture frequently estimate components corresponding to fractions individual genomes that trace specific ancestral populations. However, the same numerical fraction can represent a wide array scenarios. Using mechanistic model admixture, we characterize genealogically: how many distinct ancestors populations does represent? We consider African Americans, for whom...