A5103007390- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Oral microbiology and periodontitis research
- Knee injuries and reconstruction techniques
- Bone and Dental Protein Studies
- Tendon Structure and Treatment
- Cancer-related molecular mechanisms research
- Foot and Ankle Surgery
- RNA Research and Splicing
- Lower Extremity Biomechanics and Pathologies
- Drug Transport and Resistance Mechanisms
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Inflammatory mediators and NSAID effects
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Rabies epidemiology and control
- Musculoskeletal synovial abnormalities and treatments
- Diagnosis and Treatment of Venous Diseases
- Osteoarthritis Treatment and Mechanisms
- Sirtuins and Resveratrol in Medicine
Hadassah Medical Center
2011-2024
Inserm
2013
Genetique Reproduction and Developpement
2013
Centre National de la Recherche Scientifique
2013
Sirtuin 1 (SirT1) has been implicated in the regulation of human cartilage homeostasis and chondrocyte survival. Exposing osteoarthritic (OA) chondrocytes to tumor necrosis factor α (TNFα) generates a stable enzymatically inactive 75-kd form SirT1 (75SirT1) via cathepsin B-mediated cleavage. Because 75SirT1 is resistant further degradation, we hypothesized that it distinct role OA, present study was undertaken identify this role.The presence B 75SirT OA normal analyzed. Confocal imaging used...
ABSTRACT Type II collagen is a key cartilaginous extracellular protein required for normal endochondral development and cartilage homeostasis. COL2A1 gene expression positively regulated by the NAD-dependent deacetylase Sirtuin 1 (SirT1), through its ability to bind chromatin regions of promoter enhancer. Although SirT1/Sox9 binding on enhancer site was previously demonstrated, little known about functional role site. Here, we examined mechanism which promoter-associated SirT1 governs...
Abstract Injuries to ligaments are common, painful and debilitating, causing joint instability impaired protective proprioception sensation around the joint. Healing of torn usually fails take place, surgical replacement or reconstruction is required. Previously, we showed that in vivo application recombinant human amelogenin protein ( rHAM + ) resulted enhanced healing tooth‐supporting tissues. The aim this study was evaluate whether might also enhance repair skeletal ligaments. rat knee...
Pyogenic flexor tenosynovitis is an uncommon, emergent hand infection. The literature lacks any description of the disease and variability its manifestations in young children. We describe 3 cases. Two cases were diagnosed treated promptly, third presented late, with atypical clinical signs, causing a delay his diagnosis treatment stressing caution to be taken evaluation these children signs
Abstract Background Diabetic Foot Ulcers (DFU) are a major complication in patients with diabetes and affect globally 170 million patients. Approximately 28% of infected DFU require amputation. foot infections (DFI) caused by persistent or multidrug resistant organisms threat to the outcome therapy. Infections mostly polymicrobial, pathogens include Staphylococcus aureus Pseudomonas aeruginosa. A promising new approach using phages may potentially be novel modality increase treatment...
Lateral ligament tears, also known as high-grade ankle sprains, are common, debilitating, and usually heal slowly. Ten to thirty percent of patients continue suffer from chronic pain instability even after 3 9 months. Previously, we showed that the recombinant human amelogenin (rHAM+ ) induced regeneration fully transected rat medial collateral ligament, a common proof-of-concept model. Our aim was evaluate whether rHAM+ can regenerate torn calcaneofibular (CFL), an important component...
Category: Diabetes Introduction/Purpose: Diabetic heel ulcers are a major problem, often leading to amputations. Partial or total calcanectomy has been described as possible salvage procedure, by allowing soft tissue coverage after debridement of necrotic and infected tissue, possibly walking. We report on our experience with this technique which is not commonly used Methods: Fourteen patients, who presented diabetic between 2010-15, were BKA candidates, underwent partial calcanectomy....
Intra-articular fractures can produce degenerative changes causing continued pain and disability, therefore optimal surgical care might be indicated. Metatarsal (MT) intra-articular are no exception. While prior literature described mainly of the first MT lateral toes, there is scarce addressing second head, which longest most robust bone. In this case series, we report three cases head fracture-dislocation their clinical outcomes. We also review pathology.