A5029046303- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Orthopedic Infections and Treatments
- Microbial infections and disease research
- Polyomavirus and related diseases
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Bacillus and Francisella bacterial research
- Pneumonia and Respiratory Infections
- Plant Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Orthopaedic implants and arthroplasty
- Antimicrobial Peptides and Activities
- Infective Endocarditis Diagnosis and Management
- Animal Virus Infections Studies
- Plant Pathogenic Bacteria Studies
- Monoclonal and Polyclonal Antibodies Research
- Plant and Fungal Interactions Research
- Sinusitis and nasal conditions
University of Cincinnati
2015-2022
Bacteriophage therapy (BT) uses bacteriophages to treat pathogenic bacteria and is an emerging strategy against multidrug-resistant (MDR) infections. Experience in solid organ transplant limited. We describe BT 3 lung recipients (LTR) with life-threatening MDR infections caused by Pseudomonas aeruginosa (n = 2) Burkholderia dolosa 1). For each patient, lytic were selected their bacterial isolates. was administered for variable durations under emergency Investigational New Drug applications...
A patient with a trauma-related left tibial infection associated extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated bacteriophages antibiotics. There rapid tissue healing positive culture eradication. As result, the patient's leg did not have to be amputated he is undergoing rehabilitation.
Prosthetic joint infection (PJI) is a potentially limb-threatening complication of total knee arthroplasty. Phage therapy promising strategy to manage such infections including those involving antibiotic-resistant microbes, and target microbial biofilms. Experience with phage for associated retained hardware limited. A 62-year-old diabetic man history right arthroplasty 11 years prior who had suffered multiple episodes prosthetic despite numerous surgeries prolonged courses antibiotics,...
Cystic fibrosis is associated with significant morbidity and early mortality due to recurrent acute chronic lung infections. The use of multiple antibiotics without pathogen eradication increases the possibility extensive drug resistance or even pan-drug (PDR). It imperative that new alternative treatment options be explored. We present a clinical case 10-year-old female cystic patient, infected PDR Achromobacter spp. She was treated cefiderocol, meropenem/vaborbactam, bacteriophage therapy...
This is a case of 72 year old male with chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage therapy. Nevertheless, treatment was successful and patient's severe infection eradicated.
Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic infection occurs rarely; it biofilm-based that poorly responsive to antibiotic alone. Recent interest bacteriophage therapy has made possible treat some infections, as well those caused by multidrug-resistant pathogens, successfully when conventional failed. Here, we describe case of 61-year-old woman who was treated after second cycle administered at time two-stage exchange for...
Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This is heightened in who on mechanical ventilation, immunocompromised, and/or have chronic comorbidities. We report the case a 52-year-old critically ill patient with Acinetobacter baumannii (MDR-A) respiratory infection was successfully treated antibiotics and intravenous nebulized bacteriophage therapy.
<title>Abstract</title> Multidrug resistant (MDR) bacterial infections without antibiotic options are a public health emergency. Infections associated with medical implants serve as an example. Conventional antibiotics have limited ability to eradicate these they antibiotic-tolerant biofilms. Here, we report the use of bacteriophage therapy for treatment MDR, non-operable <italic>Pseudomonas aeruginosa</italic> periprosthetic joint infection that had failed multiple and surgical...
has the ability to exhibit resistance a broad range of antibiotics, highlighting importance identifying alternative or adjunctive treatment options, such as phages.
We present a case of refractory methicillin-resistant Staphylococcus aureus that was successfully treated with combination antibiotics, systemic phage and intranasal therapy.
Given the specificity of bacteriophage attachment receptors, a single bacterial isolate is currently utilized to match therapeutic, thereby extrapolating activity all bacteria in vivo. Consistently, main receptor for Staphylococcus aureus teichoic acid, and it known that this has phenotypic variations different vivo environments. Consequently, aim study was determine whether similar across prosthetic joint infection environments.Three patients with infections who had S. grow from...
Introduction: Treating recurrent multidrug resistant (MDR) urosepsis in pediatric transplant recipients can be challenging. Particularly when antibiotics fail to prevent future occurrence and the nidus is seemingly undiscoverable. While there an increasing amount of data on phage therapy, our knowledge, are no published cases involving renal recipients. Therefore, we present a challenging clinical case which therapy was used recipient who developed MDR with unclear source. Case Presentation:...
Standardized approaches to phage susceptibility testing (PST) are essential inform selection of phages for study in patients with bacterial infections. There is no reference standard assessing phage. We compared agreement between PST performed at three centers: two centers using a liquid assay standardized the sites third, plaque assay. Four
Phage therapy is a promising antibacterial strategy, especially given that drug-resistant bacterial infections are escalating worldwide. Because phages not active against all strains of species, being considered for therapeutic use would ideally be tested isolates from individual patients prior to administration. Standardized, clinically validated phage susceptibility testing (PST) methods needed assessing
A small subset of acidic hot springs sampled in Yellowstone National Park yielded rod-shaped viruses which lysed liquid host cultures and formed clear plaques on lawns cells. Three isolates chosen for detailed analysis were found to be genetically related previously described the Sulfolobus islandicus virus (SIRV), but distinct from them each other. Functional stability new was assessed a series inactivation experiments. UV-C radiation inactivated one somewhat faster than bacteriophage λ,...
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) biofilms can be resilient to the human immune system and antibiotics, a challenge augmented by acquired antimicrobial resistance. Phage therapy is being evaluated for biofilm-associated infections. Methods Here, model phages SaMD07ø1 SaRB105030ø5 were against their hosts SaMD07 SaRB105030, respectively, grown as in 96-well plates, on glass beads planktonically. Trypticase soy broth (TSB) phosphate buffered saline (PBS)...
Abstract Successful phage therapy for extensive chronic osteoarticular infection in a child resulted an initial flush of bacterial contents into the bloodstream with inflammatory response marked by fever, local pain and upregulation genes associated autophagy innate immunity. Monitoring kinetics human host allowed early dose adjustment indicated strong therapeutic effect within two weeks.