A5081058691- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Plant Virus Research Studies
- Vibrio bacteria research studies
- Nematode management and characterization studies
- Animal Disease Management and Epidemiology
- Pharmaceutical Economics and Policy
- Legume Nitrogen Fixing Symbiosis
- Data-Driven Disease Surveillance
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Antimicrobial agents and applications
- Plant-Microbe Interactions and Immunity
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Health and Medical Research Impacts
- Monoclonal and Polyclonal Antibodies Research
Mayo Clinic in Arizona
2024
Mayo Clinic
2023-2024
National Centre for Cell Science
2022
National Environmental Engineering Research Institute
2016-2018
Agharkar Research Institute
2017
Abstract Fenugreek (Trigonella foenum-graecum Linn.), is an extensively cultivated legume crop used as a herb, spice, and traditional medicine in India. The symbiotic efficiency plant growth-promoting potential of fenugreek rhizobia depend on the symbiont strain environmental factors. We isolated 176 root-nodulating bacteria from different agroclimatic regions MALDI-TOF MS-based identification phylogenetic analyses based 16S rRNA five housekeeping genes classified fenugreek-rhizobia Ensifer...
Abstract Addressing the treatment and prevention of antibacterial-resistant gram-negative bacterial infections is a priority area Antibacterial Resistance Leadership Group (ARLG). The ARLG has conducted series observational studies to define clinical molecular global epidemiology carbapenem-resistant ceftriaxone-resistant Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, with goal optimizing design execution interventional studies. One ongoing study aims better understand...
The antibacterial efficacy and specificity of lytic bacteriophages (phages) make them promising therapeutics for treatment multidrug-resistant bacterial infections. Restricted penetration phages through the protective matrix biofilms, however, may limit their against biofilm Here, engineered polymers were used to generate noncovalent phage-polymer nanoassemblies (PPNs) that penetrate biofilms kill resident bacteria. Phage K, active multiple strains
Clinical research networks conduct important studies that would not otherwise be performed by other entities. In the case of Antibacterial Resistance Leadership Group (ARLG), such include diagnostic using master protocols, controlled phage intervention trials, and evaluate treatment strategies or dynamic interventions, as sequences empiric definitive therapies. However, value a clinical network lies only in results from these but creation new approaches derived collaborative thinking,...
Abstract In this overview, we describe important contributions from the Antibacterial Resistance Leadership Group (ARLG) to patient care, clinical trials design, and mentorship while outlining future priorities. The ARLG research agenda is focused on 3 key areas: gram-positive infections, gram-negative diagnostics. has developed an innovative approach desirability of outcome ranking (DOOR), which uses ordinal measure global assess both benefits harms. DOOR was initially applied observational...
Standardized approaches to phage susceptibility testing (PST) are essential inform selection of phages for study in patients with bacterial infections. There is no reference standard assessing phage. We compared agreement between PST performed at three centers: two centers using a liquid assay standardized the sites third, plaque assay. Four
Phage therapy is a promising antibacterial strategy, especially given that drug-resistant bacterial infections are escalating worldwide. Because phages not active against all strains of species, being considered for therapeutic use would ideally be tested isolates from individual patients prior to administration. Standardized, clinically validated phage susceptibility testing (PST) methods needed assessing
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) biofilms can be resilient to the human immune system and antibiotics, a challenge augmented by acquired antimicrobial resistance. Phage therapy is being evaluated for biofilm-associated infections. Methods Here, model phages SaMD07ø1 SaRB105030ø5 were against their hosts SaMD07 SaRB105030, respectively, grown as in 96-well plates, on glass beads planktonically. Trypticase soy broth (TSB) phosphate buffered saline (PBS)...