A5100412124- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Berberine and alkaloids research
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Alkaloids: synthesis and pharmacology
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Connective tissue disorders research
- Breast Cancer Treatment Studies
- Biochemical Acid Research Studies
- Curcumin's Biomedical Applications
- FOXO transcription factor regulation
- Analytical Chemistry and Sensors
Xiangya Hospital Central South University
2016-2024
Central South University
2016-2024
Jilin Agricultural University
2024
Dalian Medical University
2022-2024
Sookmyung Women's University
2024
Dali University
2024
Nankai University
2024
Tiangong University
2024
University of California, San Francisco
2018-2023
George Washington University
2023
Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with great risk of relapse after primary treatment. Through analysis whole genome expression profiling data in NPC samples, we found that the long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense (AFAP1-AS1), is significantly correlated escape marker programmed death (PD-1). We therefore assessed AFAP1-AS1 PD-1 cohort 96 paraffin-embedded samples confirmed are co-expressed...
Altered expression of long non-coding RNAs (lncRNAs) associated with human carcinogenesis and might be used as diagnosis prognosis biomarkers. However, the lncRNAs in tongue squamous cell carcinoma (TSCC) their relevance on diagnosis, progression TSCC have not been thoroughly elucidated. To discover novel TSCC-related lncRNAs, we analyzed lncRNA patterns two sets previously published gene profile data (GSE30784 GSE9844), found that intergenic RNA 152 (LINC00152) was significantly upregulated...
// Jianjun Yu 1, * , Yan Liu 2, Zhaojian Gong 3, 4 Shanshan Zhang 3 Can Guo 2 Xiayu Li 5 Yanyan Tang Liting Yang Yi He Fang Wei Yumin Wang Qianjin Liao Wenling Xiaoling Yong 6 Guiyuan Xiong Zhaoyang Zeng 1 Department of Head and Neck Surgery, Hunan Cancer Hospital The Affiliated Xiangya School Medicine, Central South University, Changsha, Hunan, China Key Laboratory Carcinogenesis the Chinese Ministry Health, Research Institute, Invasion Education, Hospital, Stomatolog, Second Nonresolving...
Abstract There is increasing evidence that long non-coding RNAs (lncRNAs) play important roles in human tumorigenesis. By using publicly available expression profiling data from lung adenocarcinoma and integrating bioinformatics analysis, we screened a lncRNA, LINC00472. LINC00472 tissues was significantly lower tightly associated with patient prognosis TNM clinical stages adenocarcinoma. also inhibited cell migration invasion increased stiffness adhesion. RNA pull down RIP assays identified...
Abstract Actin filament associated protein 1 antisense RNA (named AFAP1-AS1) is a long non-coding and overexpressed in many cancers. This study aimed to identify the role mechanism of AFAP1-AS1 lung cancer. The expression was firstly assessed 187 paraffin-embedded cancer 36 normal epithelial tissues by situ hybridization. migration invasion abilities were investigated cells. To uncover molecular about function cancer, we screened proteins that interact with pull down mass spectrometry...
Long non-coding RNAs (lncRNAs) are dysregulated in various cancers. However, the clinical relevance and functional roles of AFAP1-AS1 colon cancer (CC) have not been clarified. We analyzed lncRNA expression patterns Gene Expression Omnibus (GEO) datasets Cancer Genome Atlas (TCGA) RNA-seq datasets, found that level was significantly elevated CC tissues. High levels were associated with poor disease-free survival overall patients. In vitro experiments demonstrated knockdown inhibited cell...
We previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression. In the present study, we aimed to investigate role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) lncRNA metastatic potential TSCC cells and its molecular mechanisms.Expression levels MALAT-1 were examined via quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) 127 samples as well...
Recent studies demonstrated that long non-coding RNAs (lncRNAs) deregulated in many cancer tissues including nasopharyngeal carcinoma (NPC) and had critical roles progression metastasis.In this study, we aimed to assess a lncRNA LINC01420 expression NPC explore its role pathogenesis.Our research revealed the level of were higher than epithelial (NPE) tissues.Moreover, patients with high showed poor overall survival.Knockdown inhibited cell migration invasion vitro.In summary, may play serve...
Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an direction to the protein-coding gene AFAP1 opposite strand. Previous studies showed that lncRNA AFAP1-AS1 was upregulated and acted as oncogene a variety of tumors. However, expression biological functions tongue squamous cell carcinoma (TSCC) are still unknown. The level measured 103 pairs human TSCC tissues corresponding adjacent normal mucous tissues. correlation between...
Abstract Nasopharyngeal carcinoma (NPC) is a unique malignant cancer with high metastasis. Because the early symptoms of NPC patients are not obvious, most have distant metastases when diagnosed, which makes treatment difficult. Long non-coding RNAs (lncRNAs) emerging as important regulators in human carcinogenesis. LncRNAs been increasingly identified but remain largely unknown NPC. Therefore, we performed gene expression profiling to screen for altered lncRNAs tissues and adjacent samples....
Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis‐associated transcript bladder cancer, LOC284837) novel lncRNA. was found to be highly expressed nasopharyngeal carcinoma (NPC), increased poor survival patients NPC. Furthermore, promoted migration invasion NPC cells vitro, well metastasis vivo ....
Epstein-Barr virus (EBV) is a tumorigenic that can cause various human malignancies such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature micro (mi)RNAs, mostly exhibiting oncogenic properties promoting progression. However, we have previously found one EBV-encoded miRNA, namely EBV-miR-BART6-3p, acts tumor suppressor by inhibiting metastasis invasion. Here, report EBV-miR-BART6-3p inhibits the proliferation of EBV-associated cancers, NPC, GC, targeting...
Abstract Background Identification of effective diagnostic and prognostic biomarkers cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation progression. The lncRNA LOC284454 distinctly expressed various head neck cancers (HNCs), as demonstrated by our previous bioinformatics analysis. However, the expression levels functions are still unclear. Methods We investigated dysregulation lncRNAs HNCs using GEO...
Abstract Addressing the treatment and prevention of antibacterial-resistant gram-negative bacterial infections is a priority area Antibacterial Resistance Leadership Group (ARLG). The ARLG has conducted series observational studies to define clinical molecular global epidemiology carbapenem-resistant ceftriaxone-resistant Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, with goal optimizing design execution interventional studies. One ongoing study aims better understand...
Doxorubicin (DOX) is a key chemotherapeutic drug for cancer treatment. The antitumor mechanism of DOX its action as topoisomerase II poison by preventing DNA replication. Our study shows that can be involved in epigenetic regulation gene transcription through downregulation methyltransferase 1 (DNMT1) then reactivation methylation-silenced tumor suppressor genes glioblastoma (GBM). Recent evidence demonstrated microRNA (miR or miRNA) mediate expression post-transcriptional and modulate...