A5100765801- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Heat shock proteins research
- Diabetes and associated disorders
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Insect Resistance and Genetics
- Cancer Mechanisms and Therapy
- Receptor Mechanisms and Signaling
- Ginseng Biological Effects and Applications
- Plant-based Medicinal Research
- Circular RNAs in diseases
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Phytochemical compounds biological activities
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Plant Genetic and Mutation Studies
- Reproductive Biology and Fertility
Nanjing University
2017-2025
Capital Medical University
2022-2025
First Affiliated Hospital of Jinan University
2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Fujian Medical University
2025
Qinghai University Affiliated Hospital
2024
Nanjing Medical University
2017-2023
Nanjing General Hospital of Nanjing Military Command
2018-2023
South China Normal University
2021-2023
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the involvement of ferroptosis in its pathological mechanism. In this study, effects and mechanism BRCA1-associated protein 1 (BAP1) on neuronal PD were evaluated. Methods: A mouse model was constructed injecting mice with MPTP. Nissl staining, immunohistochemistry, immunofluorescence, Prussian blue staining evaluated histopathology iron distribution. The cell subjecting SK-N-SH cells to MPP+. m6A level...
Exosomes can transfer genetic materials between cells. Their roles in viral infections are beginning to be appreciated. Researches have shown that exosomes released from virus-infected cells contain a variety of and host cellular factors able modulate recipient's response result productive infection the recipient host. Here, we showed EV71 resulted upregulated exosome secretion differential packaging genomic RNA miR-146a into exosomes. We provided evidence showing was preferentially enriched...
Long noncoding RNA (lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis‐associated transcript bladder cancer, LOC284837) novel lncRNA. was found to be highly expressed nasopharyngeal carcinoma (NPC), increased poor survival patients NPC. Furthermore, promoted migration invasion NPC cells vitro, well metastasis vivo ....
Objective: Baicalin, a kind of flavonoid extracted from the dry root Scutellaria, possesses potent anticancer bioactivities in various tumor cell lines. Accumulating evidences show that baicalin induces autophagy and apoptosis to suppress cancer growth. Moreover, antineoplastic role human glioblastoma cells remains be uncovered. Methods: Both U87 U251 lines were employed present study. Cell viability was tested by Counting Kit-8 colony-forming assay; Flow cytometry analyze apoptosis, cycle,...
ABSTRACT Background Epilepsy has a genetic predisposition, yet causal factors and the dynamics of immune environment in epilepsy are not fully understood. Methods We analyzed peripheral blood samples from patients, identifying key genes associated with risk through Mendelian randomization, using eQTLGen genome‐wide association studies. The environment's composition was explored CIBERSORT. An mouse model established to validated expression at transcriptomic proteomic levels single‐cell...
Diabetes retinopathy (DR) is a prevalent microvascular complication of type 2 diabetes mellitus (T2DM). This study investigated the correlation between renal function and DR, as well potential mediating role geriatric nutritional risk index (GNRI). We classified 1122 adults with T2DM aged ≥ 40 years from National Health Nutrition Examination Survey database (2005–2008) into groups: those DR without DR. used multivariate logistic regression analysis restricted cubic spline (RCS) model to...
Optical and electrochemical detection of biothiols based on aggregation individual sensing elements.
Glioblastoma (GBM) is an aggressive intracranial tumour, and current chemotherapy regimens have limited efficacy. Aloperine (ALO), a natural alkaline compound, has shown potential as antitumor agent. However, the effect of ALO against GBM remains unclear. This study aimed to investigate function in treating GBM. U87, A172, GL261 cell lines were used for vitro experiments, was also establish vivo models. The results showed that inhibited proliferation cells by cycle arrest apoptosis....
Cathepsin S (CTSS), a lysosomal cysteine protease, is overexpressed in various cancers, including glioblastoma (GB). A high level of CTSS associated with tumor progression and poor outcome GB. However, the underlying mechanisms its role biological characteristics G5B remain to be elucidated. Here, we uncovered potential lysosomes mitochondria GB cells (GBCs). Downregulation GBCs could increase expression autophagy-related proteins; however, there was no significant change p62, suggesting...
Abstract Busulfan is an antineoplastic, which always accompanied with the abnormal of spermatogonia self‐renewal and differentiation. It has been demonstrated that omega‐3 polyunsaturated fatty acids (PUFAs) benefits mature spermatozoa. However, whether can protect endogenous detailed mechanisms are still unclear. Evaluate spermatogenesis function (in vivo) were examined by histopathological analysis, immunofluorescence staining, western blotting. The levels lipid metabolites in testicular...
Seminal plasma (SP), particularly SP exosomes (sExos), alters with age and can affect female mouse uterine immune microenvironment. However, the relationship between fertility decline in reproductively older males, sExos age-related changes, which may compromise microenvironment, remains unclear. The present study demonstrated that implantation rate of mice treated from male (aged-SP group) was lower than those younger (young-SP group). RNA-sequencing analysis revealed altered levels...
Genital Chlamydia trachomatis infection is the most common bacterial sexual transmitted disease that causes severe complications including pelvic inflammatory disease, ectopic pregnancy, and infertility in females. The Pgp3 protein encoded by C. plasmid has been speculated to be an important player chlamydial pathogenesis. However, precise function of this unknown thus remains thoroughly investigated.In study, we synthesized for vitro stimulation Hela cervical carcinoma cells.We showed...